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--- |
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title: DeepCritical |
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emoji: 🧬 |
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colorFrom: blue |
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colorTo: purple |
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sdk: gradio |
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sdk_version: "5.33.0" |
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python_version: "3.11" |
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app_file: src/app.py |
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pinned: false |
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license: mit |
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tags: |
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- mcp-in-action-track-enterprise |
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- mcp-hackathon |
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- drug-repurposing |
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- biomedical-ai |
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- pydantic-ai |
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- llamaindex |
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- modal |
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--- |
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# DeepCritical |
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AI-Powered Drug Repurposing Research Agent |
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## Features |
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- **Multi-Source Search**: PubMed, ClinicalTrials.gov, bioRxiv/medRxiv |
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- **MCP Integration**: Use our tools from Claude Desktop or any MCP client |
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- **Modal Sandbox**: Secure execution of AI-generated statistical code |
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- **LlamaIndex RAG**: Semantic search and evidence synthesis |
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## Quick Start |
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### 1. Environment Setup |
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```bash |
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# Install uv if you haven't already |
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pip install uv |
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# Sync dependencies |
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uv sync |
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``` |
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### 2. Run the UI |
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```bash |
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# Start the Gradio app |
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uv run python src/app.py |
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``` |
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Open your browser to `http://localhost:7860`. |
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### 3. Connect via MCP |
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This application exposes a Model Context Protocol (MCP) server, allowing you to use its search tools directly from Claude Desktop or other MCP clients. |
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**MCP Server URL**: `http://localhost:7860/gradio_api/mcp/` |
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**Claude Desktop Configuration**: |
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Add this to your `claude_desktop_config.json`: |
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```json |
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{ |
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"mcpServers": { |
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"deepcritical": { |
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"url": "http://localhost:7860/gradio_api/mcp/" |
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} |
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} |
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} |
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``` |
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**Available Tools**: |
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- `search_pubmed`: Search peer-reviewed biomedical literature. |
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- `search_clinical_trials`: Search ClinicalTrials.gov. |
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- `search_biorxiv`: Search bioRxiv/medRxiv preprints. |
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- `search_all`: Search all sources simultaneously. |
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- `analyze_hypothesis`: Secure statistical analysis using Modal sandboxes. |
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## Development |
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### Run Tests |
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```bash |
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uv run pytest |
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``` |
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### Run Checks |
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```bash |
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make check |
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``` |
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## Architecture |
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DeepCritical uses a Vertical Slice Architecture: |
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1. **Search Slice**: Retrieving evidence from PubMed, ClinicalTrials.gov, and bioRxiv. |
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2. **Judge Slice**: Evaluating evidence quality using LLMs. |
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3. **Orchestrator Slice**: Managing the research loop and UI. |
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Built with: |
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- **PydanticAI**: For robust agent interactions. |
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- **Gradio**: For the streaming user interface. |
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- **PubMed, ClinicalTrials.gov, bioRxiv**: For biomedical data. |
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- **MCP**: For universal tool access. |
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- **Modal**: For secure code execution. |
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## Team |
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- The-Obstacle-Is-The-Way |
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- MarioAderman |
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- Josephrp |
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## Links |
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- [GitHub Repository](https://github.com/The-Obstacle-Is-The-Way/DeepCritical-1) |
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