Invasive listeriosis in Denmark
Abstract number: 1134_04_32
Gerner-Smidt P., Schiellerup P., Christensen J.J., Engberg J., Fussing V., Jensen A., Jensen C., Petersen A.M., Bruun B.G.
To review epidemiological, clinical, and microbiological data on 299 cases of invasive listeriosis, excluding materno-fetal cases, occurring in Denmark during the last 10 years.
Data regarding age, sex, isolation site, underlying diseases or conditions, immunosuppressive treatment, and clinical outcome within 1 month of diagnosis of infection, were analysed. Strains were submitted from 294 cases. The strains were serogrouped using antisera and further serotyped by PCR.
Results and conclusions:
The annual incidence of invasive listeriosis ranged from 0.42 to 0.73 per 100,000 inhabitants. Of the 299 invasive cases in 298 patients, 221 were blood stream infections, 71 CNS infections, and seven focal infections (prosthetic infections in bones and joints plus peritonitis). Conditions known to predispose to infection were found in 70% of cases. Patients were evenly distributed throughout Denmark, and half of them were older than 70 years. Death occurred in 21% of cases. Blood stream and CNS infections carried the same mortality, while there were no deaths in patients with focal infections. Multivariate analysis disclosed the following: conditions known to predispose to infection were strongly related to death in patients below 70 years of age; above this age underlying conditions were not related to increased risk of death; and strains of serotype 4b caused higher case fatality than strains of serotypes 1/2a and 1/2c.
|Session name:||XXIst ISTH Congress|
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