- Do not use if oil appears to be separating out of the emulsion.
PREPARE: IV Infusion: Allow preparations that have been refrigerated to stand at room temperature for about 30 min before using whenever possible.
Check with a pharmacist before mixing fat emulsions with electrolytes, vitamins, drugs, or other nutrient solutions.
ADMINISTER: IV Infusion for Adult: ?? 10% emulsion: Infuse at 1 mL/min for first 1530 min; increase to 2 mL/min if no adverse reactions.?? 20% emulsion: Infuse at 0.5 mL/min for first 1530 min; increase to 2 mL/min if no adverse reactions occur. IV Infusion for Child: ?? 10% emulsion: Infuse at 0.1 mL/min for first 1015 min; increase to 1 g/kg in 4 h if no adverse reactions occur.??Do not exceed 100 mL/h.?? 20% emulsion: Infuse at 0.05 mL/min for first 1015 min; increase to 1 g/kg in 4 h if no adverse reactions occur.??Do not exceed 50 mL/h. IV Infusion for Premature Neonate: ??Infuse at rate not to exceed 0.15 g/kg/h. IV Infussion for All Patients: ??Give fat emulsions via a separate peripheral site or by piggyback into same vein receiving amino acid injection and dextrose
mixtures or give by piggyback through a Y-connector near infusion site so that the two solutions mix only in a short piece
of tubing proximal to needle.??Must hang fat emulsions higher than hyperalimentation solution bottle to prevent backup of fat emulsion into primary line.??Do not use an in-line filter because size of fat particles is larger than pore size.??Control flow rate of each solution by separate infusion pumps.??Use a constant rate over 2024 h to reduce risk of hyperlipemia in neonates and prematures because they tend to metabolize
INCOMPATIBILITIES Solution/additive: Aminophylline, amphotericin B, ampicillin, calcium chloride, calcium gluconate, dextrose 10%, gentamicin, hetastarch, magnesium chloride, penicillin G, phenytoin, ranitidine, vitamin B complex. Y-site: Acyclovir, albumin, amphotericin B, cyclosporine, doxorubicin, doxycycline, droperidol, ganciclovir, haloperidol, heparin, hetastarch, hydromorphone, levorphanol, lorazepam, midazolam, minocycline, nalbuphine, ondansetron, pentobarbital, phenobarbital, potassium phosphate, sodium phosphate.