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1 Switching in the presence of known resistance mutations for indi- vidual drugs (modified from Soriano 2000) Previous drug Nelfinavir Nelfinavir Nevirapine Nevirapine Stavudine Stavudine Stavudine Resistance mutation D30N L90M Y181C K103N none 215, 41 MDR New drug Other Pis Not saquinavir, boost new PI, preferably lopi- navirr Efavirenz No NNRTIs Zidovudine Didanosine, lamivudine Didanosine MDR multidrug resistance Hoffmann, Kamps.
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