This is pretty technical and tough to wade through but shows how losing the ability to properly process and utilize insulin increases appetite and obesity....[B]as occurs with chronically elevated insulin levels leading to insulin resistance.[/B][/QUOTE]
Regarding the bolded line, that's the unproven assumption underlying the insulin hypothesis. Since you like research, perhaps you would be willing to find me a study supporting that assertion. Everything I've read indicates ectopic fat deposition and the resulting lipotoxicity and inflammation dysregulates insulin signaling and precedes insulin resistance and glucotoxicity. If there's research showing otherwise, I'd like to see it.