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CAPLUS COPYRIGHT 2012 ACS
||Process for preparation of temozolomide
||Turchetta, Stefano; De Ferra, Lorenzo; Zenoni, Maurizio; Anibaldi, Mauro
||Chemi SpA, Italy
||Eur. Pat. Appl., 9pp. CODEN: EPXXDW
This invention provides a process for the preparation of temozolomide. For example, 5-aminoimidazole-4-carboxamide was reacted with N-succinimidyl-N'-Me carbamate in the presence of diisopropylethylamine to obtain 5-amino-N1-Me-imidazole-1,4-dicarboxamide, followed by cyclization with a nitrite, chromatog. purification, and crystallization to give the title compound.
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View the full-text U.S. patent from USPTO.