Spontaneous dissection of the superior mesenteric artery and the right hepatic artery: a case report
© Buchs et al; licensee BioMed Central Ltd. 2010
Received: 13 October 2009
Accepted: 16 March 2010
Published: 16 March 2010
Isolated spontaneous dissection of the superior mesenteric artery is a very rare condition. Endovascular stent placement has been proposed recently for selected cases, which has led to some good clinical results.
We report a case of spontaneous dissection of the superior mesenteric artery spreading to the origin of a right hepatic artery in a 48-year-old Chinese man. He benefited from the placement of an endovascular stent that yielded excellent results.
Endovascular stent placement is a good alternative treatment for dissection of the superior mesenteric artery. We propose an algorithm for the management of this rare condition.
Isolated spontaneous dissection of the superior mesenteric artery (SMA), without the involvement of the abdominal aorta, is a very rare condition [1, 2]. Fewer than 80 cases have been reported in the literature since the first case described by Bauerfeld in 1947 .
The majority of patients who present with hypovolemic shock or peritonitis are treated surgically [4, 5], while asymptomatic patients have occasionally been managed conservatively [1, 6, 7]. Recently, endovascular stent placement has been proposed for selected cases, and this has led to some good results [2, 8–11].
We report a case of spontaneous dissection of the SMA that had spread to the origin of the right hepatic artery. We describe a relatively new and promising therapeutic approach in this case report. Finally, we propose an algorithm for the management of an isolated dissection of the SMA.
A 48-year-old Chinese man was admitted to the Emergency Department at the University Hospitals of Geneva with a sudden onset of severe epigastric pain and an episode of bilious vomiting that subsided completely within a few hours. He had no relevant medical history except hypercholesterolemia. He also denied any history of arterial hypertension, diabetes mellitus or any recent trauma. On physical examination, our patient was pale and sweaty with a temperature of 36.8°C, a regular heart rate of 84 beats per minute and a blood pressure of 130/70 mmHg. An examination of his abdomen revealed epigastric tenderness without signs of peritonism. His white blood cell count was 8.3 × 109 cells/L and his C-reactive protein was 3 mg/L. His liver function tests, serum lipase and amylase levels were normal. His cardiac troponins were 0.012 μg/L and his electrocardiogram result was normal.
After the procedure, our patient commenced treatment with long-term 100 mg aspirin, which was combined with an oral loading dose of 300 mg clopidogrel, followed by 75 mg clopidogrel daily for 28 days. A Doppler ultrasonography was performed at 24 hours then seven days after the stent placement. This showed patency of the endoprosthesis with normal spectral Doppler waveforms in the main distal branches of the SMA. Our patient was discharged eight days after the procedure and has remained completely asymptomatic during the following three months.
The SMA is the second most frequent site of isolated spontaneous peripheral arterial dissection after the carotid artery. This condition was first described in 1947 by Brauenfeld .
Its management can be categorized into three different eras. Before the 1970s, all patients died, while from the 1970s until the early 2000s surgery remained the only successful option. In 1998, Yasuhara et al.  reported the first cases of patients with spontaneous SMA dissection who recovered fully without undergoing surgery. In 2000, Sparks et al. initiated a conservative approach with anticoagulation ; while Leung et al. described percutaneous endovascular treatment .
This evolution in the management of SMA is concordant with the improvement in CT resolution and interventional radiology which have enabled the diagnosis of dissection to be made more frequently, thus encouraging the application of non-invasive procedures. Sakamoto et al.  reported detailed morphological models of dissection, while distinguishing between four types of lesions. On this basis they established a set of treatment modalities for isolated spontaneous SMA dissection.
We differentiate between three modalities of clinical presentation: an asymptomatic patient whose dissection is an incidental finding, a patient with acute transient pain or chronic relapsing pain (non-continuous pain), and a patient with acute ongoing pain (continuous pain).
In the first type of presentation, we suggest using anticoagulation and close follow-up with serial CTs. We deem this approach valid as CT angiography has been proven to be as accurate as catheter angiography in evaluating the location and extent of the dissection [14, 15]. As recommended for carotid artery dissection , anticoagulation should prevent thrombosis of the true lumen and embolic events. There is no current recommendation for the intervals between the scans . Very close follow-up must be continued as asymptomatic progressive dissection or thrombosis of the true lumen may occur.
For symptomatic patients (transient or ongoing pain), treatment is mandatory  even if pain may only be related to inflammation around the dissecting SMA and does not necessarily correspond to acute intestinal ischemia . However, it has been well-demonstrated recently that symptomatic patients have had complete resolution of their abdominal pain after a stent placement .
Our patient belongs to the category of patients who develop acute transient pain, which ceases spontaneously, and who have no signs of ischemia on CT. With this clinical presentation, we believed that angiography should be performed, and endovascular treatment of the lesion should be considered. According to Ozaki et al. , conservative management or minimally invasive procedures may be alternatives to surgery in such cases. Close follow-up is also recommended with particular attention to any new abdominal pain. We had some concern regarding our patient's right hepatic vascularization. Fortunately, angiography documented collaterals and preserved perfusion through his right hepatic artery after the stent placement. The post-operative period was uneventful and no derangement of his liver function tests was observed. It is obvious that this form of management can only be considered if a high level of competency in radiological interventions is locally available.
Surgery is mandatory for patients with continuous pain and/or signs of intestinal ischemia on CT. For patients with transient pain, however, a percutaneous approach performed in specialized centers should be considered. Finally, a conservative approach using anticoagulation and close follow-up is recommended for incidental findings.
Written informed consent was obtained from our patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
We would like to thank Lisa Gamble, MD for editing this manuscript.
- Takayama H, Takeda S, Saitoh SK, Hayashi H, Takano T, Tanaka K: Spontaneous isolated dissection of the superior mesenteric artery. Intern Med. 2002, 41 (9): 713-716. 10.2169/internalmedicine.41.713.View ArticlePubMed
- Miyamoto N, Sakurai Y, Hirokami M, Takahashi K, Nishimori H, Tsuji K, Kang JH, Maguchi H: Endovascular stent placement for isolated spontaneous dissection of the superior mesenteric artery: report of a case. Radiat Med. 2005, 23 (7): 520-524.PubMed
- Bauerfeld S, Jackson F: Dissecting aneurysm of the aorta: a presentation of 15 cases and a review of the recent literature. Ann Intern Med. 1947, 26: 873-889.View Article
- Iha K, Nakasone Y, Nakachi H, Horikawa Y, Gushiken M, Matsuda H: Surgical treatment of spontaneous dissection of the superior mesenteric artery: a case report. Ann Thorac Cardiovasc Surg. 2000, 6 (1): 65-69.PubMed
- Solis MM, Ranval TJ, McFarland DR, Eidt JF: Surgical treatment of superior mesenteric artery dissecting aneurysm and simultaneous celiac artery compression. Ann Vasc Surg. 1993, 7 (5): 457-462. 10.1007/BF02002130.View ArticlePubMed
- Sakamoto I, Ogawa Y, Sueyoshi E, Fukui K, Murakami T, Uetani M: Imaging appearances and management of isolated spontaneous dissection of the superior mesenteric artery. Eur J Radiol. 2007, 64 (1): 103-110. 10.1016/j.ejrad.2007.05.027.View ArticlePubMed
- Nagai T, Torishima R, Uchida A, Nakashima H, Takahashi K, Okawara H, Oga M, Suzuki K, Miyamoto S, Sato R, Murakami K, Fujioka T: Spontaneous dissection of the superior mesenteric artery in four cases treated with anticoagulation therapy. Intern Med. 2004, 43 (6): 473-478. 10.2169/internalmedicine.43.473.View ArticlePubMed
- Yoon YW, Choi D, Cho SY, Lee DY: Successful treatment of isolated spontaneous superior mesenteric artery dissection with stent placement. Cardiovasc Intervent Radiol. 2003, 26 (5): 475-478. 10.1007/s00270-003-0002-4.View ArticlePubMed
- Leung DA, Schneider E, Kubik-Huch R, Marincek B, Pfammatter T: Acute mesenteric ischemia caused by spontaneous isolated dissection of the superior mesenteric artery: treatment by percutaneous stent placement. Eur Radiol. 2000, 10 (12): 1916-1919. 10.1007/s003300000520.View ArticlePubMed
- Froment P, Alerci M, Vandoni RE, Bogen M, Gertsch P, Galeazzi G: Stenting of a spontaneous dissection of the superior mesenteric artery: a new therapeutic approach?. Cardiovasc Intervent Radiol. 2004, 27 (5): 529-532. 10.1007/s00270-003-0158-y.View ArticlePubMed
- Kim JH, Roh BS, Lee YH, Choi SS, So BJ: Isolated spontaneous dissection of the superior mesenteric artery: percutaneous stent placement in two patients. Korean J Radiol. 2004, 5 (2): 134-138. 10.3348/kjr.2004.5.2.134.PubMed CentralView ArticlePubMed
- Yasuhara H, Shigematsu H, Muto T: Self-limited spontaneous dissection of the main trunk of the superior mesenteric artery. J Vasc Surg. 1998, 27 (4): 776-779. 10.1016/S0741-5214(98)70250-2.View ArticlePubMed
- Sparks SR, Vasquez JC, Bergan JJ, Owens EL: Failure of non-operative management of isolated superior mesenteric artery dissection. Ann Vasc Surg. 2000, 14 (2): 105-109. 10.1007/s100169910019.View ArticlePubMed
- Furukawa H, Moriyama N: Spontaneous dissection of the superior mesenteric artery diagnosed on multi-detector helical CT. J Comput Assist Tomogr. 2002, 26 (1): 143-144. 10.1097/00004728-200201000-00025.View ArticlePubMed
- Sheldon PJ, Esther JB, Sheldon EL, Sparks SR, Brophy DP, Oglevie SB: Spontaneous dissection of the superior mesenteric artery. Cardiovasc Intervent Radiol. 2001, 24 (5): 329-331. 10.1007/s00270-001-2565-0.View ArticlePubMed
- Karacagil S, Hardemark HG, Bergqvist D: Spontaneous internal carotid artery dissection. Review. Int Angiol. 1996, 15 (4): 291-294.PubMed
- Gobble RM, Brill ER, Rockman CB, Hecht EM, Lamparello PJ, Jacobowitz GR, Maldonado TS: Endovascular treatment of spontaneous dissections of the superior mesenteric artery. J Vasc Surg. 2009, 50 (6): 1326-1332. 10.1016/j.jvs.2009.07.019.View ArticlePubMed
- Ozaki T, Kimura M, Yoshimura N, Hori Y, Takano T, Kamura T, Yamamoto S, Sasai K: Endovascular treatment of spontaneous isolated dissecting aneurysm of the superior mesenteric artery using stent-assisted coil embolization. Cardiovasc Intervent Radiol. 2006, 29 (3): 435-437. 10.1007/s00270-005-0067-3.View ArticlePubMed
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