In its early phases, chronic kidney disease usually doesn’t cause symptoms. However, as the condition progresses to the end-stage renal disease stage, it can cause a number of symptoms, including: Feeling weak or tiredTrouble sleepingSwelling of feet and anklesPoor appetiteNeeding to urinate more often, especially at nightMuscle cramping at nightNauseaItchingShortness of breathMetallic taste in mouthChest painConfusionHiccupsIrritabilityDifficulty concentratingReduced interest in sexMenstrual irregularitiesNumbness and tingling in hands and feet
National Kidney Foundation. Kidney Disease Outcomes Quality Initiative (K/DOQI) clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification.
Am J Kidney Dis.
Snyder S, Pendergraph B. Detection and evaluation of chronic kidney disease.
Am Fam Physicians.
Last reviewed May 2015 by Michael Woods, MD
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