Bindu, PJ and Mahadevan, KM and Satyanarayan, ND and Naik, Ravikumar TR (2012) Synthesis and DNA cleavage studies of novel quinoline oxime esters. In: Bioorganic & Medicinal Chemistry Letters, 22 (2). pp. 898-900.
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New 2-chloro-3-formyl quinoline oxime esters were synthesized by the reaction of 2-chloro-3-formyl quinoline oximes with various benzoyl chlorides in the presence of triethyl amine and dichloromethane at 0 degrees C. The DNA photo cleavage studies of some new oxime esters were investigated by neutral agarose gel electrophoresis at different concentrations (40 mu M and 80 mu M). Analysis of the cleavage products in agarose gel indicated that few of quinoline oxime esters (3d-i) converted into supercoiled pUC19 plasmid DNA to its nicked or linear form. (C) 2011 Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Keywords:||Quinoline;Oxime ester;DNA;Photo cleavage|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||27 Feb 2012 12:20|
|Last Modified:||27 Feb 2012 12:20|
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