This peptide sequence is found in residues 45 to 54 of Metastin (also referred to as Kisspeptin-10). This peptide increases plasma concentrations of GH (Growth Hormone) and LH (Luteinizing Hormone) in prepubertal dairy heifers. This peptide is the minimal sequence needed to activate GPR54 signaling, which may function in negatively regulating CXCR4’s role in programming tumor metastasis. Specifically, Kisspeptin-10 inhibits signaling and chemotaxis induced by SDF-1.
Kadokawa, H. et al. J. Endocrinol. 196, 331 (2008); Kotani, M. et al. J. Biol. Chem. 276, 34631 (2001); Navenot, J.M. et al. Cancer Res, 65, 10450 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Tyr - Asn - Trp - Asn - Ser - Phe - Gly - Leu - Arg - Phe - NH2