News-Medical.net - HIPK2 Regulator Protein Plays a Crucial Role In Kidney Fibrosis
Researchers from Mount Sinai School of Medicine have identified a regulator protein that plays a crucial role in kidney fibrosis, a condition that leads to kidney failure.
Led by John Ci-jiang He, MD, PhD, Professor of Nephrology and Pharmacology and Systems Therapeutics; and Avi Ma'ayan, PhD, Assistant Professor of Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine, the research team studied three mouse models of kidney fibrosis: one group contained HIV viral proteins incorporated into their genome; the second was injected with a high dose of folic acid; in the third, kidney filtration was blocked in one kidney. All of these factors cause kidney fibrosis. "Our findings have important implications for people with kidney diseases, patients I treat every day," said Dr. He. Learn More