Ultraviolet radiation-induced lipid peroxidation in liposomal membrane: Modification by capsaicin
Article first published online: 18 JAN 2006
Copyright © 1993 John Wiley & Sons, Ltd.
Volume 7, Issue 1, pages 87–89, January/February 1993
How to Cite
De, A. K., Ghosh, J. J. and Mandal, T. K. (1993), Ultraviolet radiation-induced lipid peroxidation in liposomal membrane: Modification by capsaicin. Phytother. Res., 7: 87–89. doi: 10.1002/ptr.2650070121
- Issue published online: 18 JAN 2006
- Article first published online: 18 JAN 2006
- Manuscript Accepted: 4 FEB 1992
- lipid peroxidation;
Ultraviolet-radiation has been reported to cause lipid peroxidation in the liposomal membrane. In the present study, treatment with capsaicin, (8-methyl-n-vanillyl-6-nonenamide), the pungent principle of red hot pepper, was shown to modify UV-induced lipid peroxidation in the liposomal membrane. Treatment with low doses of capsaicin (less than 0.1 μg/mL of phosphatidyl choline liposome) produced a significant increase in UV-induced lipid peroxidation, while high doses (0.1–0.5 μg/mL of PC liposome) caused a significant decrease of UV-induced peroxidation. These pro-oxidant and antioxidant activities of capsaicin over UV-induced liposomal lipid peroxidation were also comparable to experiments modulated with standard pro-oxidant ferrous sulphate and antioxidant sodium azide. The observed dual nature of capsaisin's action on the UV-induced lipid peroxidation of the liposomal membrane may be attributed to the previously reported “activation” followed by “desensitization” action of capsaicin on other membrane lipid systems.