The fifth Knesset started with David Ben-Gurion's Mapai party forming the tenth government on 2 November 1961. His coalition included the National Religious Party, Ahdut HaAvoda, Agudat Israel Workers, Cooperation and Brotherhood and Progress and Development, and had 13 ministers. Kadish Luz of Mapai was appointed Knesset Speaker. The government collapsed when Ben-Gurion resigned on 16 June 1963 citing personal reasons, but in reality was annoyed at a perceived lack of support from his colleagues. He later broke away from Mapai with several colleagues to form Rafi.
Levi Eshkol took over Mapai and formed the eleventh government on 26 June 1963 with the same coalition partners as previously, but one more minister. The government resigned on 10 December 1964 when Ben-Gurion demanded that members of the Supreme Court investigate the Lavon Affair.
Eshkol formed the twelfth government a week later on 22 December 1964 with the same coalition partners and ministers as previously.
The fifth Knesset was notable for the coalescing of the two major right-wing parties (Herut and the Liberal Party) to form an electoral block (Gahal) capable of threatening Mapai's hegemony in Israeli politics. Gahal, which by then had become Likud, finally overtook Mapai (which had merged into the Alignment) in the 1977 elections.