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Recently Published Articles
- The Effect of Sterilization Methods on the Structural and Chemical Properties of Fibrin Microthread Scaffolds
Jonathan M. Grasman, Megan P. O'Brien, Kevin Ackerman, Keith A. Gagnon, Gregory M. Wong and George D. Pins
Article first published online: 4 FEB 2016 | DOI: 10.1002/mabi.201500410
The structural and chemical properties of fibrin-based scaffolds are affected by crosslinking and sterilization protocols. Ethanol and ethylene oxide gas sterilization procedures are performed on uncrosslinked, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), or ultraviolet light crosslinked fibrin microthreads to evaluate the mechanical, structural, and chemical properties of these materials. The data presented here inform the strategic design of fibrin-based scaffolds.
- Crosslinked Redox-Responsive Micelles Based on Lipoic Acid-Derived Amphiphiles for Enhanced siRNA Delivery
Ariane Tschiche, Bala N. S. Thota, Falko Neumann, Andreas Schäfer, Nan Ma and Rainer Haag
Article first published online: 4 FEB 2016 | DOI: 10.1002/mabi.201500363
Disulfide-based reversibly stabilized micelles based on crosslinkable lipoic acid amphiphiles are developed in the present study, which show degradation upon reductive conditions, and thus lead to efficient cargo release. In particular, one candidate out of this series is able to efficiently release siRNA due to its redox-responsive biodegradable profile, thereby leading to potent gene silencing.
- pH-Triggered Charge-Reversal Polyurethane Micelles for Controlled Release of Doxorubicin
Wanying He, Xu Zheng, Qi Zhao, Lijie Duan, Qiang Lv, Guang Hui Gao and Shuangjiang Yu
Article first published online: 3 FEB 2016 | DOI: 10.1002/mabi.201500358
A pH-triggered charge-reversal nanocarrier is fabricated for efficient anticancer-drug delivery. The charge-reversal behavior is tunable by changing the molar ratio of piperazine/carboxyl. With reducing the pH, the surface charge of nanocarriers can be changed from negative to positive which enhance the cellular uptake and intracellular drug release.
- Biodegradable Self-Assembled Nanoparticles of Galactose-Containing Amphiphilic Triblock Copolymers for Targeted Delivery of Paclitaxel to HepG2 Cells
Tieshi Wang, Xinde Tang, Jingtian Han, Yuanyuan Ding, Wenjuan Guo and Meishan Pei
Article first published online: 2 FEB 2016 | DOI: 10.1002/mabi.201500413
Biodegradable self-assembled nanoparticles of galactose-containing amphiphilic triblock copolymers are used as carriers of paclitaxel to achieve targeted delivery to HepG2 cells. The polymeric NPs are biocompatible and non-toxic, and can be selectively recognized.
- A Supramolecular Approach toward Bioinspired PAMAM-Dendronized Fusion Toxins
Seah Ling Kuan, Christina Förtsch, David Yuen Wah Ng, Stephan Fischer, Yu Tokura, Weina Liu, Yuzhou Wu, Kaloian Koynov, Holger Barth and Tanja Weil
Article first published online: 2 FEB 2016 | DOI: 10.1002/mabi.201500417
Supramolecular fusion toxins, which involve the C3 protein from Clostridium botulinum noncovalently fused to polyamidoamine-dendronized transporter proteins are prepared using a bottom-up molecular self-assembly, which allows the uptake behavior of the toxin to be reprogrammed and holds great promise as an innovative chemical tool for re-engineering protein therapeutics.