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Process for the synthesis of cefaclor
The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with...
Analyzing and distinguishing organisms such as bacterial spores by their
Organisms such as bacterial spores are analyzed and/or characterized based on based on peptide fragments of a set of selectively solublizede proteins. Libraries...
Bioluminescent protease assay
A sensitive bioluminescent assay to detect proteases including caspases, trypsin and tryptase is provided.
Screening assays for agents that alter inhibitor of apoptosis (IAP)
protein regulation of caspase activity
The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for...
Method and apparatus for viable and nonviable prokaryotic and eukaryotic
A rapid method for the quantitation of various live cell types is described. This new cell fluorescence method correlates with other methods of enumerating...
Flow cytometric method and kit for metal-induced sensitivity
This invention provides methods for determining metal-induced sensitivity of a subject and kits for affecting the same. Specifically, the invention provides...
Methods for diagnosing and treating kidney cancer
Methods, reagents and kits for diagnosing and treating kidney cancer are disclosed. An immunoassay for detecting kidney cancer is based on the relative change...
Human monoclonal antibodies that bind human insulin like growth factors
and their use
Antibody compositions and methods for treatment of neoplastic disease in a mammalian subject are provided. Methods of diagnosing cancer in a mammalian subject...
Method for identifying differentially expressed proteins
The invention provides a method of identifying an antigen that is present in different amounts in two different samples. In general, the methods involve...
Methods for up-regulating antigen expression in tumors
The invention provides methods of modulating tumor antigen associated (TAA) expression, and methods of modulating TAA expression in order to treat a tumor. More...
Use of specific T2R taste receptors to identify compounds that block
Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The...
Rapid microbial detection and antimicrobial susceptibiility testing
A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to...
High throughput method and system for screening candidate compounds for
activity against target ion channels
Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the...
Methods for detection of hydrophobic drugs
Methods and reagents are disclosed for pretreating a sample suspected of containing a hydrophobic drug for conducting an assay method for detecting the...
Diagnostic method for celiac sprue
Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.
Detecting Bcl-B expression in cancer and uses thereof
Provided herein are compositions and methods of detecting Bcl-B expression in cancer cells to prognose, monitor, or select therapies for cancers such as breast...
Immunocellular receptors related to neurological disorders and therapeutic
Class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central...
Primers and primer sets for use in methods to detect the presence of
Acidovorax avenae subsp. citrulli
The present invention relates to oligonucleotide primers and primer sets that can be used to identify the bacterial pathogen Acidovorax avenae subsp. citrulli...
Methods for producing and using stem-loop oligonucleotides
The present invention concerns preparation of DNA molecules, such as a library, using a stem-loop oligonucleotide. In particular embodiments, the invention...
Methods and compositions for amplification of RNA sequences
The invention provides methods for isothermal amplification of RNA. The methods are particularly suitable for amplifying a plurality of RNA species in a sample....
Method for the high throughput screening of transposon tagging populations
and massive parallel sequence...
A method for the identification of a gene in a transposon population is provided. The method comprises isolating genomic DNA, optionally pooling the DNA,...
Methods for rapid identification of pathogens in humans and animals
The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents...
Recombinase polymerase amplification
The present invention features novel, diverse, hybrid and engineered recombinase enzymes, and the utility of such proteins with associated recombination factors...
Method of detecting relative risk for the onset of atopic dermatitis by
gene single nucleotide polymorphism...
The present invention provides a method of discriminating a relative risk for the morbidity of atopic dermatitis of a test subject comprising: analyzing gene...
Methods for quantitating small RNA molecules
In one aspect, the present invention provides methods for amplifying a microRNA molecule to produce DNA molecules. The methods each include the steps of: (a)...
Microarray-mediated diagnosis of herpes virus infection by monitoring
host's differential gene expression upon...
The present invention discloses disease-associated molecules and assays, which are useful for diagnosing and assessing those animals with herpes virus...
Methods for detecting a polymorphism in the NFKB1 gene promoter
The present invention discloses a functional relationship between a recognized disease condition and a polymorphism in the nucleotide factor kappa B promoter...
Reagents and methods for detecting Neisseria gonorrhoeae
This invention provides compositions and methods for detecting Neisseria gonorrhoeae in a sample. This invention also provides related reaction mixtures, kits,...
Genetic polymorphisms associated with liver fibrosis methods of detection
and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the...
Method of isolating nucleic acids from a biological sample
Method of preparing a biological sample appropriate for use in a subsequent in vitro nucleic acid amplification reaction. The method involves a rapid, transient...
The objects of the present invention are: elucidation of an enzyme that phosphorylates in vivo a compound such as ...
Methods for predicting the response of multiple sclerosis patients to
interferon therapy and diagnosing...
The present invention relates to a method of diagnosing a predisposition of a multiple sclerosis (MS) patient for responsiveness to a treatment of MS by...
Increased ethanol production from xylose
Methods and compositions for the production of ethanol from lignocellulosic starting materials are provided herein. Embodiments of the invention provide methods...
Method for the diagnosis and treatment of cardiovascular diseases
The present invention refers to a method for the in vitro or in vivo diagnosis of cardiovascular diseases, in particular high blood pressure, stenosis, vessel...
Nucleic acid interaction analysis
The present invention provides an isolated oligonucleotide and a method using the isolated oligonucleotide to detect and/or identify at least two ...
DNA-based methods of geochemical prospecting
The present invention relates to methods for performing surveys of the genetic diversity of a population. The invention also relates to methods for performing...
Cancer therapy sensitizer
The present invention relates to compositions and methods for sensitizing cancer therapy. The invention provides such compositions comprising a SPARC family...
PRRG4-associated compositions and methods of use thereof in methods of
Compositions and methods for detecting PRRG4- and PRRG2 associated molecules are provided as are methods of use thereof for the detection and treatment of cancer.
Leukemia diagnostic methods
The present invention provides methods and compositions for the diagnosis, prognosis and treatment of chronic lymphocytic leukemia (CLL). The invention also...
Genetic polymorphisms associated with venous thrombosis, methods of
detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with venous thrombosis. In particular, the present invention...
Hypermethylation of GATA-4 and GATA-5 transcription factor genes in cancer
Methods are provided for identifying the presence of cancer cells in a sample by detecting hypermethylation of the promoter region of a GATA-4 transcription...
Synthesis of hybrid polynucleotide molecules using single-stranded
A method to make libraries of hybrid polynucleotide molecules of two parental polynucleotide molecules utilizing single-stranded DNA was invented. Example of...
Methods and reagents for detecting target binding by nucleic acid ligands
The present invention provides novel methods and reagents for detecting the binding of protein targets to nucleic acid ligands. Using Universal Protein Stains...
Pharmaceutical and therapeutic applications relating to a type 9 adenylyl
cyclase Polymorphism in asthma and...
A pharmaceutical composition comprising an expression product of a Type Nine adenylyl cyclase gene polymorphism, along with a suitable physiological carrier,...
Gene expression profiling in biopsied tumor tissues
The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention...
Zinc finger protein derivatives and methods of using same
The present invention provides zinc finger nucleotide binding polypeptide variants that have at least three zinc finger modules that bind to a target cellular...
Methods and compositions for determining altered susceptibility of HIV-1
to anti-HIV drugs
This invention relates, in part, to methods and compositions for determining altered susceptibility of a human immunodeficiency virus ("HIV") to the...
Methods and apparatus for screening for chromosomal abnormalities
This invention generally relates to methods, apparatus, and computer program code for antenatal screening for chromosomal abnormalities, in particular Down's...
Method of storing red blood cells with an acidic additive solution under
There is provided compositions and methods for the storage of red blood cells. The compositions are additive solutions comprising adenine, dextrose, mannitol,...
Media solutions and methods for cryopreservation and thawing of in vitro
A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to...