PAIN® Open Access Articles
The latest Open Access articles published in PAIN®.
Yong Chen | Patrick Kanju | Quan Fang | Suk Hee Lee | Puja K. Parekh | Whasil Lee | Carlene Moore | Daniel Brenner | Robert W. Gereau | Fan Wang | Wolfgang Liedtke
SummaryFormalin-evoked trigeminal pain behavior depends on TRPV4 calcium-permeable channels, also on MEK-ERK signaling in trigeminal ganglion neurons.
Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis
Marta Seretny | Gillian L. Currie | Emily S. Sena | Sabrina Ramnarine | Robin Grant | Malcolm R. MacLeod | Leslie A. Colvin | Marie Fallon
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling pain condition resulting from chemotherapy for cancer. Severe acute CIPN may require chemotherapy dose reduction or cessation. There...
Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission
Xiaona Du | Han Hao | Sylvain Gigout | Dongyang Huang | Yuehui Yang | Li Li | Caixue Wang | Danielle Sundt | David B. Jaffe | Hailin Zhang | Nikita Gamper
SummaryWe identified major ion channels influencing the resting membrane potential of nociceptive sensory neurons and demonstrated that changes of somatic/perisomatic membrane potential of these neurons can strongly influence peripheral nociceptive transmission.
Selective innervation of NK1 receptor–lacking lamina I spinoparabrachial neurons by presumed nonpeptidergic Aδ nociceptors in the rat
Najma Baseer | Abdullah S. Al-Baloushi | Masahiko Watanabe | Safa A.S. Shehab | Andrew J. Todd
SummaryThis study provides evidence that nonpeptidergic Aδ nociceptive primary afferents selectively innervate lamina I spinoparabrachial projection neurons that lack the neurokinin 1 receptor.
Noxious stimulation in children receiving general anaesthesia evokes an increase in delta frequency brain activity
Caroline Hartley | Ravi Poorun | Sezgi Goksan | Alan Worley | Stewart Boyd | Richard Rogers | Tariq Ali | Rebeccah Slater
SummaryClinically required noxious cannulation performed in children receiving sevoflurane monoanaesthesia causes a change in electrophysiological brain activity.
Daniel G. Jamieson | Andrew Moss | Michael Kennedy | Sherrie Jones | Goran Nenadic | David L. Robertson | Ben Sidders
SummaryProtein interactions from painful states form a coherent network that can be used to inform further study. We identify proteins key to painful subnetworks.
Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy: Data from the randomized, double-blind, COMBO-DN study
Didier Bouhassira | Stefan Wilhelm | Alexander Schacht | Serge Perrot | Eva Kosek | Giorgio Cruccu | Rainer Freynhagen | Solomon Tesfaye | Alberto Lledó | Ernest Choy | Paolo Marchettini | Juan Antonio Micó | Michael Spaeth | Vladimir Skljarevski | Thomas Tölle
SummaryDuloxetine and pregabalin have different effects on neuropathic pain components. This might explain differential responses to these drugs when given either alone or in combination.
Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: A comparison with topical menthol
Ryan Patel | Leonor Gonçalves | Mathew Leveridge | Stephen R. Mack | Alan Hendrick | Nicola L. Brice | Anthony H. Dickenson
SummaryAn in vivo electrophysiological characterisation of the pro- and anti-nociceptive effects of TRPM8 agonists reveals menthol and a novel TRPM8 agonist have selective inhibitory effects on cold sensitivity in neuropathic rats.
Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease–derived stimuli
James R.F. Hockley | George Boundouki | Vincent Cibert-Goton | Cian McGuire | Ping K. Yip | Christopher Chan | Michael Tranter | John N. Wood | Mohammed A. Nassar | L. Ashley Blackshaw | Qasim Aziz | Gregory J. Michael | Mark D. Baker | Wendy J. Winchester | Charles H. Knowles | David C. Bulmer
SummaryNaV1.9 regulates normal colonic afferent mechanosensation and is required for hypersensitivity to noxious inflammatory mediators and those derived from inflammatory bowel disease tissues.
Estimating the burden of disease in chronic pain with and without neuropathic characteristics: Does the choice between the EQ-5D and SF-6D matter?
Nicola Torrance | Kenny D. Lawson | Ebenezer Afolabi | Michael I. Bennett | Michael G. Serpell | Kate M. Dunn | Blair H. Smith
SummaryChronic pain with neuropathic characteristics is associated with significantly lower EQ-5D and Short Form 6D health utilities scores, with 17% reporting health states “worse than death”.
Differential structural and resting state connectivity between insular subdivisions and other pain-related brain regions
K. Wiech | S. Jbabdi | C.S. Lin | J. Andersson | I. Tracey
SummaryThe anterior, mid, and posterior insula show differential structural and resting state connectivity with other pain-related brain regions.
Capillary dysfunction and impaired tissue oxygenation in complex regional pain syndrome: A hypothesis
Leif Østergaard | Astrid Juhl Terkelsen | Nanna Brix Finnerup | Lone Knudsen | Kim Ryun Drasbek | Sune Nørhøj Jespersen | Peter Svensson | Jens Christian H. Sørensen | Troels Staehelin Jensen
Sensory, psychological, and metabolic dysfunction in HIV-associated peripheral neuropathy: A cross-sectional deep profiling study
Tudor J.C. Phillips | Matthew Brown | Juan D. Ramirez | James Perkins | Yohannes W. Woldeamanuel | Amanda C. de C. Williams | Christine Orengo | David L.H. Bennett | Istvan Bodi | Sarah Cox | Christoph Maier | Elena K. Krumova | Andrew S.C. Rice
SummaryStudy participants with HIV-associated sensory polyneuropathy (HIV-SN) had higher plasma triglyceride concentrations, depression, anxiety, catastrophizing scores, and prevalence of insomnia than HIV participants without HIV-SN.
Tear fluid hyperosmolality increases nerve impulse activity of cold thermoreceptor endings of the cornea
Andres Parra | Omar Gonzalez-Gonzalez | Juana Gallar | Carlos Belmonte
SummaryHyperosmolality equivalent to that seen in evaporative dry eye primarily increases background activity of corneal cold thermoreceptors, maybe underlying discomfort sensations developed during dry eye condition.
Marta Ceko | Nevena Milenkovic | Philipp le Coutre | Jörg Westermann | Gary R. Lewin
SummaryThe perception of painful stimuli is altered in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors such as Imatinib and Nilotinib.
A comparison of the clinical and experimental characteristics of four acute surgical pain models: Dental extraction, bunionectomy, joint replacement, and soft tissue surgery
Neil K. Singla | Paul J. Desjardins | Phoebe D. Chang
When a clinical trial of an analgesic produces a negative finding, it is important to consider the influence (if any) of experimental error on the validity of that result. Although efforts to identify...
Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury
Beatrice Lana | Bettina Schlick | Stuart Martin | Wendy S. Pratt | Karen M. Page | Leonor Goncalves | Wahida Rahman | Anthony H. Dickenson | Claudia S. Bauer | Annette C. Dolphin
SummaryA minor α2δ-1 splice-variant, (ΔA+BΔC), with reduced affinity for gabapentin, is differentially upregulated in DRG neurons following ligation. This could influence the efficacy of gabapentin.
Flavia Mancini | Thomas Nash | Gian Domenico Iannetti | Patrick Haggard
SummaryWe tested whether, how, and where intrasegmental touch modulates the perception of laser-evoked, acute pain. We provide evidence for a spatial organisation of touch–pain interactions within a single dermatome.
Sally Martin | Clare Daniel | Amanda C. de C. Williams
SummaryConstructions of neuropathic pain in a volunteer sample of people with neuropathic pain differed in major themes: the importance of cause, particularly nerve damage; symptomatic treatment; and psychological involvement. There was no evidence of a coherent biopsychosocial lay model for neuropathic pain.
Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat
Charlie H.T. Kwok | Ian M. Devonshire | Andrew J. Bennett | Gareth J. Hathway
Significant opioid-dependent changes occur during the fourth postnatal week in supraspinal sites (rostroventral medulla [RVM], periaqueductal grey [PAG]) that are involved in the descending control...
PainNetworks: A web-based resource for the visualisation of pain-related genes in the context of their network associations
James R. Perkins | Jonathan Lees | Ana Antunes-Martins | Ilhem Diboun | Stephen B. McMahon | David L.H. Bennett | Christine Orengo
Hundreds of genes are proposed to contribute to nociception and pain perception. Historically, most studies of pain-related genes have examined them in isolation or alongside a handful of other genes....
Functional differences between neurochemically defined populations of inhibitory interneurons in the rat spinal dorsal horn
Erika Polgár | Thomas C.P. Sardella | Sheena Y.X. Tiong | Samantha Locke | Masahiko Watanabe | Andrew J. Todd
SummaryNeurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the spinal cord differ in their receptor expression pattern and responses to noxious stimuli.
Duloxetine and pregabalin: High-dose monotherapy or their combination? The “COMBO-DN study” – a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain
Solomon Tesfaye | Stefan Wilhelm | Alberto Lledo | Alexander Schacht | Thomas Tölle | Didier Bouhassira | Giorgio Cruccu | Vladimir Skljarevski | Rainer Freynhagen
SummaryCombination of the standard doses of duloxetine and pregabalin was not superior to the maximum dose of either drug in patients with painful diabetic neuropathy.
Franziska Denk | Wenlong Huang | Ben Sidders | Angela Bithell | Megan Crow | John Grist | Simone Sharma | Daniel Ziemek | Andrew S.C. Rice | Noel J. Buckley | Stephen B. McMahon
Histone deacetylase inhibitors (HDACIs) interfere with the epigenetic process of histone acetylation and are known to have analgesic properties in models of chronic inflammatory pain. The aim of this...
Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury
S.W. Hughes | L. Hickey | R.P. Hulse | B.M. Lumb | A.E. Pickering
SummaryA role for the pontospinal noradrenergic system to dynamically restrict the spatiotemporal expression of the neuropathic pain phenotype in a nerve injury model.
David Coggon | Georgia Ntani | Keith T. Palmer | Vanda E. Felli | Raul Harari | Lope H. Barrero | Sarah A. Felknor | David Gimeno | Anna Cattrell | Sergio Vargas-Prada | Matteo Bonzini | Eleni Solidaki | Eda Merisalu | Rima R. Habib | Farideh Sadeghian | M. Masood Kadir | Sudath S.P. Warnakulasuriya | Ko Matsudaira | Busisiwe Nyantumbu | Malcolm R. Sim | Helen Harcombe | Ken Cox | Maria H. Marziale | Leila M. Sarquis | Florencia Harari | Rocio Freire | Natalia Harari | Magda V. Monroy | Leonardo A. Quintana | Marianela Rojas | Eduardo J. Salazar Vega | E. Clare Harris | Consol Serra | J. Miguel Martinez | George Delclos | Fernando G. Benavides | Michele Carugno | Marco M. Ferrario | Angela C. Pesatori | Leda Chatzi | Panos Bitsios | Manolis Kogevinas | Kristel Oha | Tuuli Sirk | Ali Sadeghian | Roshini J. Peiris-John | Nalini Sathiakumar | A. Rajitha Wickremasinghe | Noriko Yoshimura | Helen L. Kelsall | Victor C.W Hoe | Donna M. Urquhart | Sarah Derrett | David McBride | Peter Herbison | Andrew Gray
SummaryIn a large cross-sectional survey, pain affecting 6–10 anatomical sites showed substantially different associations with risk factors from pain limited to 1–3 sites.
Paul Campbell | Annette Bishop | Kate M. Dunn | Chris J. Main | Elaine Thomas | Nadine E. Foster
The biopsychosocial model is increasingly accepted in low back pain (LBP) research and clinical practice. In order to assess the role of psychological factors in the development and persistence of pain,...
Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation
Inmaculada Silos-Santiago | Gerhard Hannig | Helene Eutamene | Elena E. Ustinova | Sylvie G. Bernier | Pei Ge | Christopher Graul | Sarah Jacobson | Hong Jin | Elaine Liong | Marco M. Kessler | Tammi Reza | Samuel Rivers | Courtney Shea | Boris Tchernychev | Alexander P. Bryant | Caroline B. Kurtz | Lionel Bueno | Michael A. Pezzone | Mark G. Currie
The natural hormone uroguanylin regulates intestinal fluid homeostasis and bowel function through activation of guanylate cyclase-C (GC-C), resulting in increased intracellular cyclic guanosine-3′,5′-monophosphate...
Asami Naka | Doris Gruber-Schoffnegger | Jürgen Sandkühler
SummaryThis study identified and characterized non-Hebbian type LTP in nociceptive pathways, a potential synaptic mechanism of secondary hyperalgesia.
Effects of motion style acupuncture treatment in acute low back pain patients with severe disability: A multicenter, randomized, controlled, comparative effectiveness trial
Joon-Shik Shin | In-Hyuk Ha | Jinho Lee | Youngkwon Choi | Me-riong Kim | Byoung-Yoon Park | Byung-Cheul Shin | Myeong Soo Lee
SummaryMotion style acupuncture treatment (MSAT) was more effective for pain relief and functional recovery than diclofenac injection in acute low back pain patients with disability.
Opioid use among low back pain patients in primary care: Is opioid prescription associated with disability at 6-month follow-up?
Julie Ashworth | Daniel J. Green | Kate M. Dunn | Kelvin P. Jordan
SummaryOpioid prescription at baseline was significantly associated with greater self-reported disability in back pain patients at 6months after adjusting for confounders.
Daily repetitive transcranial magnetic stimulation of primary motor cortex for neuropathic pain: A randomized, multicenter, double-blind, crossover, sham-controlled trial
Koichi Hosomi | Toshio Shimokawa | Katsunori Ikoma | Yusaku Nakamura | Kenji Sugiyama | Yoshikazu Ugawa | Takenori Uozumi | Takamitsu Yamamoto | Youichi Saitoh
SummaryThe double-blinded randomized controlled trial showed that daily repetitive transcranial magnetic stimulation of primary motor cortex provided short-term positive effect on neuropathic pain without serious adverse events.
Kathryn J. Paterson | Laura Zambreanu | David L.H. Bennett | Stephen B. McMahon
SummaryAn optimised model was developed to investigate in vivo mechanics of bradykinin and analogues in human skin using iontophoresis and an inflammatory model.
David Coggon | Georgia Ntani | Keith T. Palmer | Vanda E. Felli | Raul Harari | Lope H. Barrero | Sarah A. Felknor | David Gimeno | Anna Cattrell | Consol Serra | Matteo Bonzini | Eleni Solidaki | Eda Merisalu | Rima R. Habib | Farideh Sadeghian | M. Masood Kadir | Sudath S.P. Warnakulasuriya | Ko Matsudaira | Busisiwe Nyantumbu | Malcolm R. Sim | Helen Harcombe | Ken Cox | Maria H. Marziale | Leila M. Sarquis | Florencia Harari | Rocio Freire | Natalia Harari | Magda V. Monroy | Leonardo A. Quintana | Marianela Rojas | Eduardo J. Salazar Vega | E. Clare Harris | Sergio Vargas-Prada | J. Miguel Martinez | George Delclos | Fernando G. Benavides | Michele Carugno | Marco M. Ferrario | Angela C. Pesatori | Leda Chatzi | Panos Bitsios | Manolis Kogevinas | Kristel Oha | Tuuli Sirk | Ali Sadeghian | Roshini J. Peiris-John | Nalini Sathiakumar | A. Rajitha Wickremasinghe | Noriko Yoshimura | Helen L. Kelsall | Victor C.W. Hoe | Donna M. Urquhart | Sarah Derrett | David McBride | Peter Herbison | Andrew Gray
SummaryLarge international variation in the prevalence of disabling forearm and low back pain was only partially explained by established personal and socioeconomic risk factors.
Martin Diers | Walter Zieglgänsberger | Jörg Trojan | Annika Mira Drevensek | Gertrud Erhardt-Raum | Herta Flor
SummaryVisual feedback of one’s own back reduces perceived pain intensity of nociceptive stimulation of the back in chronic back pain patients and in healthy controls.
Intravenous acetaminophen reduces postoperative nausea and vomiting: A systematic review and meta-analysis
Christian C. Apfel | Alparslan Turan | Kimberly Souza | Joseph Pergolizzi | Cyrill Hornuss
SummaryProphylactically administered intravenous acetaminophen for postsurgical pain reduces postoperative nausea and vomiting. This effect is unrelated to the opioid-sparing effect, but correlates with superior pain control.
Nicola Torrance | Janice A. Ferguson | Ebenezer Afolabi | Michael I. Bennett | Michael G. Serpell | Kate M. Dunn | Blair H. Smith
SummaryThere is a significant proportion of chronic pain that is persistent and neuropathic, appears undertreated or untreated, and is associated with poor health and quality of life.
Siri Leknes | Chantal Berna | Michael C. Lee | Gregory D. Snyder | Guido Biele | Irene Tracey
SummaryWhen moderate pain was presented in a context of intense pain, it induced a relief and ‘hedonic flip’ such that pain was reported as pleasant.
Michael C. Lee | Markus Ploner | Katja Wiech | Ulrike Bingel | Vishvarani Wanigasekera | Jonathan Brooks | David K. Menon | Irene Tracey
SummaryfMRI evidence suggests that delta-9-tetrahydrocannabinol, the psychoactive component of cannabis, targets the affective aspects of pain in humans by altering the activity and functional connections of the amygdala.
Intelligence in childhood and chronic widespread pain in middle age: The National Child Development Survey
Catharine R. Gale | Ian J. Deary | Cyrus Cooper | G. David Batty
TOC summaryIn 6902 middle-aged men and women, lower intelligence in childhood was associated with an increased risk of chronic widespread pain at age 45years.
Simon Beggs | Debie Alvares | Andrew Moss | Gillian Currie | Jacqueta Middleton | Michael W. Salter | Maria Fitzgerald
TOC summaryNewborn skin wounding causes an upregulation of NT-3 and cutaneous sensory hyperinnervation that contributes to the increased pain and sensitivity associated with wounding.
Partial nerve injury induces electrophysiological changes in conducting (uninjured) nociceptive and nonnociceptive DRG neurons: Possible relationships to aspects of peripheral neuropathic pain and paresthesias
Laiche Djouhri | Xin Fang | Stella Koutsikou | Sally N. Lawson
SummaryAfter partial nerve injury, changes in uninjured nociceptors and nonnociceptors (spontaneous firing, decreased electrical thresholds, hyperpolarisation) may account for the different aspects of neuropathic and paresthesias.
Intermediate Charcot-Marie-Tooth disease due to a novel Trp101Stop myelin protein zero mutation associated with debilitating neuropathic pain
Juan D. Ramirez | Phillip R.J. Barnes | Kerry R. Mills | David L.H. Bennett
TOC summaryInherited neuropathies present with striking variety in their phenotype. We present a family with a myelin protein zero mutation and disabling neuropathic pain.
The effect of changes in lower limb pain on the rate of progression of locomotor disability in middle and old age: Evidence from the NorStOP cohort with 6-year follow-up
Sara Muller | Elaine Thomas | George Peat
SummaryLower limb pain is an important determinant of locomotor disability. Recurrent episodes of pain may have a cumulative effect on functional decline in later life.
Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labelling
Andrew R. Segerdahl | Jingyi Xie | Kathryn Paterson | Juan D. Ramirez | Irene Tracey | David L.H. Bennett
SummaryUsing a composite diagnostic-neuroimaging approach, this study shows the modulatory effects of pleasant cooling on pain-related cortical regions in a subject suffering from inherited erythromelalgia.
A critical period in the supraspinal control of pain: opioid-dependent changes in brainstem rostroventral medulla function in preadolescence
Gareth J. Hathway | David Vega-Avelaira | Maria Fitzgerald
SummaryThe supraspinal control of spinal nociceptive processing matures during a specific period of postnatal development. This process is dependent upon the actions of endogenous opioid peptides.
Shafaq Sikandar | Anthony H. Dickenson
SummaryElectrophysiology and immunohistochemistry were used to investigate rat spinal and brainstem differences in somatic and visceral nociceptive processing and pregabalin efficacy in acute visceral pain.
Nucleotides control the excitability of sensory neurons via two P2Y receptors and a bifurcated signaling cascade
Arsalan Yousuf | Felicia Klinger | Klaus Schicker | Stefan Boehm
SummaryAdenosine triphosphate and its degradation product adenosine diphosphate excite sensory neurons via 2 different G protein-coupled receptors, P2Y1 and P2Y2, which mediate inhibition KV7 and sensitization of TRPV1 channels.