Q: Do DNA polymerases hop over gaps?
wgschech at med.uni-tuebingen.de
Tue Nov 4 12:45:32 EST 1997
Salvete, molbio godesses and gods!
Please imagine two primers with a small gap (1 to 4 nucleotides
long) between them annealed to a piece of DNA. Will polymerases stop
at this gap waiting for nucleotides to come and do e.g. some
proofreading while hanging around ?
or will they just run over the gap, leaving it unfixed?
Any ideas, opinions, knowledge?
I Appreciate all input.
usual disclaimers apply
University of Tuebingen
email: wgschech at med.uni-tuebingen.de
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