The Chang laboratory studies craniofacial sinus development and disease. Our primary focus is on CFTR, an ion channel mutated in cystic fibrosis, and its role in the pathogenesis of sinus pneumatization and CF sinusitis. Our laboratory has identified that CF sinus hypoplasia occurs prior to infection and inflammation in a novel animal model. We are also investigating methods to correct the CFTR defect in sinus epithelia, via gene therapy vectors, correctors, and topical therapies. Our laboratory is funded by the National Institutes of Health.
Our current areas of focus are:
- The role of ASL pH in CF sinusitis
- The effect of CFTR in olfaction (sense of smell) 3. Genetic and environmental influences in craniofacial development 4. Gene therapy vectors to correct the CFTR defect in the paranasal sinus
unknown, Peter Taft, Tanner Wallen, Eugene Chang, unknown