RKRSRAE (60298-1) is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Ia (Km = 59 mM) over PKG II (Km = 305 mM). The Vmax/Km of the peptide substrate is significantly increased by peptide-546, a PKG activator.
Ref: Hall, KU. et al. J. Biol. Chem. 274, 3485 (1999); Huggins, JP. et al. Eur. J. Biochem. 221, 581 (1994).