dFOXO may be an integrator of cellular stress. We propose a model in which dFOXO senses different forms of cellular stress (that is, nutrient deprivation or reactive oxygen species) and induces cellular responses, such as proliferation arrest, in part by repressing translation via upregulation of d4E-BP. The various signaling proteins shown in the figure are discussed in the text.
Jünger et al. Journal of Biology 2003 2:20 doi:10.1186/1475-4924-2-20