Quickly translate given gene IDs to corresponding gene
names in a batch way
Provide links for each genes to DAVID Gene Report for
Search functionally related genes within user's input gene
list or genome
Key Concepts of
"Search Related Genes"
gene is associating with a set of annotation terms. If genes share
similar set of those terms (annotation profile), they are most likely
involved in similar biological mechanisms. The algorithm adopts kappa
statistics to quantitatively measure the degree of the agreement how
genes share the ~75,000 annotation terms collected by DAVID
knowledgebase. For any given gene(s), the tool instantly searches and
lists the related genes passed kappa similarity measurement threshold.
The searching scope could be within user’s input gene list, selected
genome or all genomes (~1.2 million genes) as user’s choice.
Genes Tool is very different and complementary to the common gene
clustering methods, such as homologous genes based on sequence
similarity; protein families based on one common biological activity.
The approach provides researchers a new way to group those functional
related genes by measuring the similarity of their global annotation
profile, which facilitates new understanding of the biological network.More