NCI Dictionary of Cancer Terms
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high grade (hy grayd)
A term used to describe cells and tissue that look abnormal under a microscope. High-grade cancer cells tend to grow and spread more quickly than low-grade cancer cells. Cancer grade may be used to help plan treatment and determine prognosis. High-grade cancers usually have a worse prognosis than low-grade cancers and may need treatment right away or treatment that is more aggressive (intensive).