Revista Peruana de Medicina Experimental y Salud Publica
versión impresa ISSN 1726-4634
LAGUNA-TORRES, V. Alberto y GRUPO DE TRABAJO DE GENOTIPIFICACION DE VIH EN SUDAMERICA et al. Distribución de los subtipos del VIH-1 en nueve países de América del Sur, 1995-2002. Rev. perú. med. exp. salud publica [online]. 2005, vol.22, n.1, pp. 12-17. ISSN 1726-4634.
Objectives: To determine human immunodeficiency virus type 1 (HIV-1) subtype distribution, and the presence of recombinant strains in Argentina, Bolivia, Colombia, Chile, Ecuador, Paraguay, Peru, Uruguay, and Venezuela using epidemiological and genotyping studies. Materials and Methods: Participants in the studies performed in nine countries were included, amongst them female sex workers, men who have sex with men (MSM), HIV-positive individuals, pregnant women, and patients with tuberculosis (TB) were included. Envelope-base heteroduplex mobility assay (env HMA) testing was used, as well as ProRT, complete sequencing, or both for determining HIV-1 subtypes. Results: 3081 HIV positive individuals were identified (out of 42 290 volunteers), prevalences from less than 1% to 29% in the different populations studied, and it was higher among MSM. 1654 samples (54%) underwent genotyping. B subtype was found in 1380 (83%) samples, F subtype was found in 218 (13%) samples, and A and C subtypes were found in 0,1% and 0,4%, respectively. BF recombinant serotypes were found in 39 samples (2%), and CRF01_AE (0,1%), CRF17_BF (0,4%), and CRF02_AG (0,1%) were also found. In Venezuela, Colombia, Ecuador, Peru, Bolivia, and Chile (Andean countries) subtype B predominated, while in Argentina, Uruguay, and Paraguay there was a high frequency of F subtype. Conclusions: In most Andean countries, HIV-1 epidemic concentrated among MSM, who are predominantly infected with B subtype. F subtype is more frequent among female sex workers in Argentina and Uruguay. This is useful information in order to implement prevention plans and future vaccine tests in this region.
Palabras llave : HIV-1; genotyping; HIV subtypes; South America.