Narayana, Yeddula and Bansal, Kushagra and Sinha, Akhauri Yash and Kapoor, Nisha and Puzo, Germain and Gilleron, Martine and Balaji, Kithiganahalli Narayanaswamy (2009) SOCS3 expression induced by PIM2 requires PKC and PI3K signaling. In: Molecular Immunology, 46 (15). pp. 2947-2954.
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Initiation of proinflammatory host immunity in response to infection represents as a key event in effective control and containment of the pathogen at the site of infection as well as in elicitation of robust immune memory responses. In the current investigation, we demonstrate that an integral cell wall antigen of the mycobacterial envelope, Phosphatidyl-myo-inositol dimannosides (PIM2) triggers Suppressor of cytokine signaling (SOCS) 3 expression in macrophages in a Toll-like receptor 2 (TLR2)-MyD88 dependent manner. Data derived from signaling perturbations suggest the involvement of phosphoinositide-3 kinase (PI3K) and protein kinase C (PKC) signaling pathways during PIM2 induced SOCS3 expression. Further, pharmacological inhibition of ERK1/2, but not of p38 MAP kinase or JNK abrogated the induced expression of SOCS3. The PIM2 induced activation of ERK1/2 was dependent on the activation of PI3K or PKC signaling which in turn regulated p65 nuclear factor -kappa B (NF-kappa B) nuclear translocation. Overall, current study delineates the role for PI3K-PKC axis and ERK1/2 signaling as key signaling events during PIM2 induced SOCS3 expression in macrophages.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Ltd.. 2009.|
|Keywords:||PIM2; TLR2; SOCS3; PI3K; PKC|
|Department/Centre:||Division of Biological Sciences > Microbiology & Cell Biology|
|Date Deposited:||20 Dec 2009 08:50|
|Last Modified:||19 Sep 2010 05:50|
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