Proliferating cells, in particular those within tumors, must reprogram their metabolism to meet the energetic and biosynthetic needs of cell growth. In addition, cells must be aware of their microenvironment to negotiate the availability of important nutrients such as glucose, glutamine, and oxygen. To understand how cells regulate these metabolic processes I employ isotope tracers, mass spectrometry, and computational modeling, which allow use to observe the kinetics of reactions within these complex biochemical networks. In turn, this information will allow us to design more effective therapeutics that target the aberrant metabolism of tumor cells.
Publications: Link to PubMed