such as "Introduction", "Conclusion"..etc
runny nose and chills? You might blame the human rhinovirus (HRV), which causes
30 to 50 percent of common colds. But in reality, it’s not the virus itself but
HRV’s ability to manipulate your genes that is the true cause of some of the
most annoying cold symptoms.
first time, researchers have shown that HRV hijacks many of your genes and causes an overblown immune response that
ends up with your nose being overblown.
published in the first issue for November of the American Thoracic Society’s
clinical research journal, the American Journal of Respiratory and Critical
Care Medicine, is the first study to comprehensively review gene changes
caused by HRV.
that while colds are usually considered to be minor infections of the nose and
throat, they can have much more serious health repercussions. “Rhinovirus is the
major cause of the common cold, but it is also an important pathogen in more
serious conditions, such as asthma and chronic obstructive pulmonary disease
(COPD),” he said.
our understanding of the biology of the common cold may eventually lead to
improvements in treatment or methods for prevention of colds,” said Dr. Ron
Turner, of the University of Virginia, one of the study’s
hours, there were virtually no differences between the control and the
HRV-inoculated group, but by the 48-hour mark, more than 6500 genes has been
significantly up- or down-regulated in the HRV subjects—many of the more highly
up-regulated genes fell into two major categories: genes making antiviral
proteins, including viperin; or genes making pro-inflammatory
“This is the
first comprehensive picture to identify several groups of genes that are likely
to contribute to the pro-inflammatory and antiviral response,” said Dr.
these data provide new insights into the host
response to HRV infection and identify several novel candidate genes that
require further study to clarify their role in disease pathogenesis,” said Dr.
Proud. “This may identify proinflammatory, or host defense pathways that could
be targeted for drug development, not only as treatments for colds but also for
viral exacerbations of asthma and COPD. The fact that genes associated with
structural ‘remodeling’ or the airways were also altered, supports further study
of the role of rhinovirus infections in airway remodeling in
View full article source here.
News release courtesy of American Thoracic Society on October 24, 2008.
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