It happened at about 3 a.m. on Bruckner Boulevard under the Bruckner Expressway in the Mott Haven section.
Witnesses say a group of people were standing outside a nightclub when some began running after hearing there was someone with a gun in the area.
One of them, Abigail Lino, was struck by a car as she was running across the roadway from Bruckner Boulevard to Austin Place, and was pronounced dead at the scene.
Car parts left behind at the scene indicated that the car involved was a silver or gray Kia or Hyundai.
Lino was the mother of a 3-year old boy.