To compare acute pain response to 2 measles-mumps-rubella vaccines.
Double-blind clinical trial.
Hospital for Sick Children, Toronto, Ontario.
Forty-nine infants 12 months of age receiving their first measles-mumps-rubella vaccination.
Random allocation to receive Priorix or M-M-R II.
Main Outcome Measures
Pain responses before (baseline) and after (within 15 seconds) vaccination were quantified by visual analog scale (VAS; range, 0-100), completed by the parent and independently by the pediatrician, and the Modified Behavioral Pain Scale (range, 0-10), scored by a coder blinded to the vaccine allocation. Crying (yes or no) and latency to the first cry after injection were also measured.
Twenty-six infants received Priorix and 23 received M-M-R II. There were no differences between the 2 groups in baseline characteristics or prevaccination baseline pain scores. Median pain scores after vaccination (Priorix vs M-M-R II) were as follows: pediatrician VAS, 15 vs 58 (P = .001); parent VAS, 22 vs 53 (P = .007); and Modified Behavioral Pain Scale, 6 vs 8 (P = .02). Median difference in pain scores (after minus before) for Priorix vs M-M-R II were as follows: pediatrician VAS, 15 vs 53 (P = .003); parent VAS, 22 vs 47 (P = .008); and Modified Behavioral Pain Scale, 3 vs 5 (P = .03). The median latency to first cry was 1.5 seconds in the Priorix group compared with 1 second in the M-M-R II group (P = .26).
Priorix vaccine causes significantly less pain than M-M-R II at the time of injection for 12-month-old infants receiving their first measles-mumps-rubella vaccination.