 mutilate fashion models and use their bodies as his canvas. After successfully tricking MOBIUS's psyche exams into passing him as sane, he was connected to the virtual STEM town of Union. There he continued his murders until Theodore Wallace contacted him with an offer to give him power in exchange for Stefano kidnapping Lily, who was the CORE of the town. After Lily was removed as the CORE, Union became a nightmare hellscape, and Stefano decided that he wanted to keep her for himself and use her power to help him create his art forever. When Sebastian is sent into Union, he finds that Stefano had been murdering MOBIUS operatives who were sent in before him and freezing them in time at the moment of death. Stefano repeatedly tries to kill Sebastian Castellanos, leading to a confrontation at a theater where Stefano detonates explosive collars on dozens of Union citizens, musing to himself that he doesn't know how he'll top this latest piece of art. 
E.V.O: The Theory of Evolution: Lucifer, the Big Bad of the PC-98 game, is far more evil than the villains of the SNES successor. Having tricked numerous civilizations in the solar system into destroying themselves, most recently on the moon, Lucifer now intends to do the same on Earth. She starts at the beginning of life by driving numerous fish insane and destroying the peaceful nature of a small fish village. Later, her attempts to Kill 'Em All become more direct, culminating in singlehandedly causing the extinction of the dinosaurs before gloating to Gaia, the embodiment of the Earth, that she killed everyone. In the last main chapter, after learning that there's still life around, she provokes a war between two colonies of Lunarian survivors by making one of them, Atlantis, obsessed with destroying everything, starting with the rival colony of Mu. This results in the destruction of both colonies. After her defeat and the establishment of human civilization, she gathers power for one last attempt to kill everyone in modern times, resulting in the destruction of the Moon and, consequently, the death of Gaia's sister, before Lucifer is finally killed for good.
Exmortis trilogy: Lord Vlaew is a cruel, power-hungry demon lord whose existence predates man and beast. Usurping his brother Azrael and sealing him away in a hellish prison to be tortured for eternity, Vlaew ruled with an iron fist over the lesser entities before being overthrown himself, and ultimately claiming his title of leader of a legion of banished entities he called the Exmortis. Billions of years later, he has Xavier Rehayem's daughter possessed when he translates the rite required to open the gates to the Crimson Realm, leading her father to kill her. When a hunter stumbles across Rehayem's house a century later, he torments him to madness until he submits and becomes the Hand of Repose, ordering the murder of five Soul Bearers to grant the Exmortis passage to Earth, brutally slaughtering most of the human race in the process. Once his legion becomes disposable to him, he manipulates Mr. Hannay—killing him when the job is done—into slaying the Hand of Repose so that he can claim dominion over the Earth Realm himself as a playground of suffering.
Fable I: Jack of Blades arrived in Albion millennia ago to lay waste to humanity for refusing to bow to him and his cohorts. Surviving the destruction of his physical body by placing his soul in a mask and possessing whomever wears it, Jack goes on to spread turmoil over the years. Attacking the village of Oakvale, Jack personally murders the young Hero of Oakvale's father, gouges out the eyes of his sister and imprisons his mother to torture her for decades. Continuing to cause destruction throughout the Hero's life, Jack eventually attacks all of Albion with his forces so he can activate the powerful Sword of Aeons by sacrificing a member of the Hero's bloodline, Jack kills the Hero's mother to claim the blade before facing him. Planning to bathe the entire world in blood, Jack returns in The Lost Chapters, attempting to corrupt the Hero into murdering his own allies before trying to possess him with his mask.
Fable II: Once a young man from Oakvale, Reaver mistakenly destroyed his village by making a pact with demons for immortality. Initially horrified by what he had done, Reaver's avarice led him to continue his bargain with the demons, routinely sacrificing unwitting people to them in return for maintaining his own eternal youth. A petty hedonist, Reaver also shoots multiple artists dead for not depicting him according to his wishes. In Fable III, Reaver becomes a greedy industrialist, using children for labor and forcing his workers into unsafe conditions, killing those who protest against him. When the Hero of Brightwall becomes the ruler of Albion, Reaver acts as an evil advisor to them, suggesting they destroy forests and schools to make room for facilities for his own business ventures.
Fable III: The monstrous Crawler is an agent of the Corrupter that seeks to destroy both Aurora and Albion. First seen using its powers to mentally force the Hero of Brightwall's mentor Walter into submission, the Crawler forces him to relive his most painful memories, slowly driving him mad before attempting the same on the Hero. Revealed to have led an attack on Aurora, the Crawler is responsible for a massacre within the nation and intends to do the same to Albion. Launching its assault, the Crawler possesses Walter and forces him to fight the Hero while it's minions attack the country, potentially killing millions.
Fahrenheit (aka Indigo Prohecy): The AI is the malevolent representative of the Purple Clan that wants the Indigo Child to gain unlimited power, plunge the world into an endless winter and exterminate humanity. Manipulating Lucas Kane by killing his ally Agatha and taking her form, the AI guides and protects Lucas, even reviving him as a living corpse when he is killed by the Oracle. Once Lucas is no longer useful, the AI attempts to destroy him even if the player gives the Indigo Child over. Arrogant and cruel, the AI has the most devastating and apocalyptic plan in the game.
Zenke is one of the members of Dorfa's Heavenly Czars and the most brutal of the group. A bloodthirsty psychopath, Zenke took Solaru Village after being ordered to take the Fury there, where he arranges a horrific system for the inhabitants. Every day, Zenke would pair up the villagers in an Involuntary Battle to the Death, usually having loved ones face off against each other. If they don't comply, Zenke would kill both of them on the spot. Even Zenke's men weren't safe, as he would kill any one of them if they ever displeased him. By the time Fang and his party come to the village to liberate it from Zenke and get the fury, he has accumulated piles of corpses, including women and children. Zenke takes Tiara hostage and orders Fang to fight in a gauntlet otherwise he'll kill her. When Fang beats the gauntlet, and Tiara was rescued secretly, Zenke in his rage decides to fight the group himself, only to be driven off. In the second timelines, Zenke still does the same, but adds more to his crimes. Losing against Fang again in the Goddess, Zenke kills off his own fairy partner, and tries to kill Fang after he offered him redemption. In the Evil Goddess route, Zenke starts off meek and sympathetic, but quickly reverts to his former self, becoming even more psychotic. No matter what timeline Fang and Eryn enters, Zenke still remains the irredeemable killer that he truly is.
Bernard, in the original version, is a cold and deceptive man with dark plans to summon an evil entity, the Vile God. One of the Four Heavenly Czars of Dorfa, Bernard leads the group's many hostile takeovers of different territories, terrorizing innocents in order to gather all the Furies around the land to gain absolute power. However, Bernard has other ideas, using the company to collect the Furies for him and then take them and summon the Vile God to gain its power since, as a descendant of the Vile God, he can inherit it. To achieve this, he manipulates Dorfa in furthering his goal and driving Sherman into madness so he can usurp Dorfa from President Haganata in another timeline. With Sherman's help, Bernard manage to summon the Vile God to the world. No longer needing Sherman, Bernard tried to sacrifice him to fully attain his power, only for it to backfire horribly when Sherman double-crossed him first.
Fallen London (formerly known as Echo Bazaar): While the Masters of the Bazaar are well known for their antipathy towards the people of London and for being amoral by human standards, most cannot truly be called evil. The same, though, cannot be said for Mr Veils, more commonly known to the citizens of London as the monstrous Vake. Presiding over the trade in cloth as his primary duty, Mr Veils spends his free time hunting victims for sport as the Vake. His modus operandi is to spike a drink known as Black Wings Absinthe with his blood and haunt the nightmares of his victims before hunting them down in the waking world. Particularly unlucky victims will consume a version spiked with prisoner's honey, thereby transporting them physically into the nightmare. In a pitch-black abyss,