33 11 70 13 COMPOUND PHYSICAL PARAMETERS
65 14 72 15 LOT NUMBER
14 15 22 16 LRC FILE NUMBER
16 16 20 17 A221
14 17 22 18 PHYSICAL STATE
16 18 71 20 A crystalline solid at room temperature which melts at > 56 C.
14 20 16 21 pH
16 21 76 27 The pH of a 50 % concentration of A221 in water was theoretically calculated to be 7.26 at 22 C from a 0.5 % solution in 79.5 % aqueous dioxane according to the extrapolation procedures of Dr. P. D. Schickedantz, Lozillard Accession Number 1662. Referenced 45- 10- 1.
14 28 23 29 SPECIFIC GRAVITY
16 30 30 31 Not Determined.
14 34 20 35 SOLUBILITY
16 36 69 39 MUTAGENICITY SOLVENTS A221 is soluble EtOH at 0.2 g/ ml, with stirring, at room temperature. Reference BC30- 88.
16 43 17 44 
16 43 73 46 A221 forms a solution in corn oil at 0.5 g/ 0.5 mL, with stirring at room temperature. Reference BC30- 8888.
15 48 18 49 ORAL
16 50 73 53 A221 forms a solution in corn oil at 0.5 g/ 0.5 mL, with stirring at room temperature. Reference BC30- 88.
15 57 26 58 ACUTE CARDIOVASCULAR
16 59 67 61 A221 is insoluble for this procedure. Reference BC30- 38
14 63 28 64 STORAGE RECOMMENDATIONS
83 64 86 73 87428306
16 68 67 69 Refrigerate in an amber glass bottle at no more than 8 C.
15 73 26 75 COMPOUND SENSITIVE TO
27 76 34 77 ☐ MOISTURE
35 76 40 77 ☐ OTHER
22 76 25 77 ☐ HEAT
17 76 20 77 ☐ AIR
15 79 40 80 SAFETY COMMENTS (SUGGESTED HANDLING PROCEDURE:
66 88 68 89 DATE
18 88 45 92 
15 88 20 89 SIGNATURE
66 88 87 90 
48 89 55 90 A - 13
84 90 90 91 FORM 
20 90 24 91 RESEARCH
24 90 28 91 CENTER
14 91 19 92 LORILLARD
