Due to gene mutation, cells proliferate and differentiate uncontrollably, and eventually develop into malignant tumors. There are many abnormal proteins encoded by mutant genes on the surface of cancer cells. It is reasonable to say that these abnormal proteins should be recognized by the body's immune system in time, and trigger an immune response to remove cancer cells at one stroke. However, due to the rapid development of tumor cells, they are very good at camouflage, Moreover, it is constantly mutated. In the face of fierce and resourceful tumor cells, the originally powerful immune cells seem to be unable and even turn a blind eye to some tumor cells. The immunosuppression formed in the tumor microenvironment makes the immune system paralyzed.
According to the above information, the study that involves researchers sequencing the DNA of tumor cells and healthy cells of each patient to identify tumor specific mutations and identify related abnormal proteins may contribute to the development of effective antitumor drugs.