<s>
Xplor-NIH	B-Application
is	O
a	O
highly	O
sophisticated	O
and	O
flexible	O
biomolecular	O
structure	O
determination	O
program	O
which	O
includes	O
an	O
interface	O
to	O
the	O
legacy	O
X-PLOR	B-Application
program	O
.	O
</s>
<s>
Xplor-NIH	B-Application
is	O
based	O
on	O
a	O
C++	B-Language
framework	O
with	O
an	O
extensive	O
Python	B-Language
interface	O
enabling	O
very	O
powerful	O
and	O
easy	O
scripting	O
of	O
complex	O
structure	O
determination	O
and	O
refinement	O
protocols	O
.	O
</s>
<s>
Currently	O
Xplor-NIH	B-Application
is	O
the	O
most	O
versatile	O
,	O
comprehensive	O
and	O
widely	O
used	O
structure	O
determination/refinement	O
package	O
in	O
NMR	O
structure	O
determination	O
.	O
</s>
