<s>
XCMS	B-Application
Online	I-Application
is	O
a	O
cloud	O
version	O
of	O
the	O
original	O
XCMS	O
technology	O
(	O
a	O
bioinformatics	O
software	O
designed	O
for	O
statistical	O
analysis	O
of	O
mass	O
spectrometry	O
data	O
)	O
,	O
created	O
by	O
the	O
Siuzdak	O
Lab	O
at	O
Scripps	O
Research	O
.	O
</s>
<s>
XCMS	B-Application
Online	I-Application
was	O
designed	O
to	O
facilitate	O
XCMS	O
analyses	O
through	O
a	O
cloud	O
portal	O
and	O
as	O
a	O
more	O
straightforward	O
(	O
non	O
command	O
driven	O
)	O
way	O
to	O
analyze	O
,	O
visualize	O
and	O
share	O
untargeted	O
metabolomic	O
data	O
.	O
</s>
<s>
XCMS	B-Application
Online	I-Application
has	O
also	O
become	O
a	O
systems	O
biology	O
tool	O
for	O
integrating	O
different	O
omic	O
data	O
sets	O
.	O
</s>
<s>
XCMS	B-Application
Online	I-Application
works	O
by	O
comparing	O
groups	O
of	O
raw	O
or	O
preprocessed	O
metabolomic	O
data	O
to	O
discover	O
metabolites	O
using	O
methods	O
such	O
as	O
nonlinear	O
retention	O
time	O
alignment	O
and	O
feature	O
detection	O
&	O
matching	O
.	O
</s>
<s>
In	O
addition	O
,	O
XCMS	B-Application
Online	I-Application
is	O
integrated	O
with	O
METLIN	O
,	O
a	O
large	O
metabolite	O
database	O
.	O
</s>
<s>
In	O
2005	O
,	O
the	O
Siuzdak	O
Lab	O
created	O
an	O
open-source	O
tool	O
named	O
XCMS	O
in	O
the	O
programming	O
language	O
R	B-Language
.	O
Noticing	O
the	O
need	O
for	O
a	O
more	O
accessible	O
,	O
graphical	O
data	O
processing	O
tool	O
they	O
created	O
the	O
cloud-based	O
XCMS	B-Application
Online	I-Application
in	O
2012	O
.	O
</s>
<s>
In	O
2017	O
it	O
was	O
shown	O
that	O
XCMS	B-Application
Online	I-Application
could	O
be	O
used	O
in	O
a	O
systems	O
biology	O
workflow	O
.	O
</s>
<s>
One	O
year	O
later	O
,	O
in	O
the	O
absence	O
of	O
a	O
publicly	O
available	O
alternative	O
,	O
a	O
version	O
of	O
XCMS	B-Application
Online	I-Application
was	O
released	O
with	O
the	O
ability	O
to	O
perform	O
multiple	O
reaction	O
monitoring	O
(	O
MRM	O
)	O
.	O
</s>
