<s>
X-PLOR	B-Application
is	O
a	O
computer	O
software	O
package	O
for	O
computational	O
structural	O
biology	O
originally	O
developed	O
by	O
Axel	O
T	O
.	O
Brunger	O
at	O
Yale	O
University	O
.	O
</s>
<s>
It	O
was	O
first	O
published	O
in	O
1987	O
as	O
an	O
offshoot	O
of	O
CHARMM	B-Application
-	O
a	O
similar	O
program	O
that	O
ran	O
on	O
supercomputers	B-Architecture
made	O
by	O
Cray	O
Inc	O
.	O
</s>
<s>
X-PLOR	B-Application
is	O
a	O
highly	O
sophisticated	O
program	O
that	O
provides	O
an	O
interface	O
between	O
theoretical	O
foundations	O
and	O
experimental	O
data	O
in	O
structural	O
biology	O
,	O
with	O
specific	O
emphasis	O
on	O
X-ray	O
crystallography	O
and	O
nuclear	O
magnetic	O
resonance	O
spectroscopy	O
in	O
solution	O
of	O
biological	O
macro-molecules	O
.	O
</s>
