<s>
Trauma	B-Application
Center	I-Application
:	I-Application
Under	I-Application
the	I-Application
Knife	I-Application
2	I-Application
is	O
a	O
2008	O
simulation	O
video	O
game	O
developed	O
by	O
Vanguard	O
for	O
the	O
Nintendo	B-Device
DS	I-Device
(	O
DS	B-Device
)	O
,	O
and	O
published	O
by	O
Atlus	O
.	O
</s>
<s>
It	O
is	O
the	O
fourth	O
game	O
in	O
the	O
Trauma	O
Center	O
series	O
and	O
a	O
direct	O
sequel	O
to	O
Trauma	B-Application
Center	I-Application
:	I-Application
Under	I-Application
the	I-Application
Knife	I-Application
(	O
2005	O
)	O
.	O
</s>
<s>
The	O
gameplay	O
combines	O
surgical	O
simulation	O
relying	O
on	O
the	O
DS	B-Device
's	O
touchscreen	O
controls	O
with	O
a	O
story	O
told	O
as	O
a	O
visual	O
novel	O
.	O
</s>
<s>
Under	B-Application
the	I-Application
Knife	I-Application
2	I-Application
was	O
developed	O
as	O
a	O
true	O
mechanical	O
and	O
narrative	O
sequel	O
to	O
the	O
original	O
game	O
,	O
using	O
the	O
same	O
controls	O
and	O
gameplay	O
style	O
in	O
contrast	O
to	O
the	O
altered	O
style	O
of	O
other	O
games	O
on	O
the	B-Operating_System
Wii	I-Operating_System
.	O
</s>
<s>
Trauma	B-Application
Center	I-Application
:	I-Application
Under	I-Application
the	I-Application
Knife	I-Application
2	I-Application
is	O
a	O
video	O
game	O
that	O
combines	O
surgical	O
simulation	O
gameplay	O
with	O
storytelling	O
using	O
non-interactive	O
visual	O
novel-style	O
cutscenes	O
using	O
static	O
scenes	O
,	O
character	O
portraits	O
,	O
and	O
text	O
with	O
rare	O
voice	O
clips	O
.	O
</s>
<s>
The	O
top	O
screen	O
of	O
the	O
Nintendo	B-Device
DS	I-Device
(	O
DS	B-Device
)	O
is	O
dedicated	O
to	O
story	O
sequences	O
and	O
level	O
statistics	O
displayed	O
as	O
2D	O
artwork	O
,	O
while	O
the	O
bottom	O
touch	O
screen	O
is	O
dedicated	O
to	O
the	O
operations	O
themselves	O
rendered	O
using	O
3D	O
models	O
.	O
</s>
<s>
The	O
ten	O
available	O
surgical	O
tools	O
—	O
which	O
range	O
from	O
a	O
scalpel	O
and	O
a	O
laser	O
to	O
ultrasound	O
and	O
a	O
defibrillator	O
to	O
revive	O
a	O
patient	O
whose	O
vitals	O
flatline	O
—	O
are	O
required	O
for	O
different	O
operations	O
and	O
injuries	O
,	O
selected	O
using	O
icons	O
along	O
the	O
edges	O
of	O
the	O
touch	O
screen	O
and	O
manipulated	O
using	O
the	O
DS	B-Device
stylus	O
.	O
</s>
<s>
While	O
multiple	O
operation	O
types	O
are	O
carried	O
over	O
from	O
Trauma	B-Application
Center	I-Application
:	I-Application
Under	I-Application
the	I-Application
Knife	I-Application
,	O
different	O
operations	O
such	O
as	O
skin	O
grafts	O
and	O
bone	O
repair	O
are	O
included	O
from	O
later	O
entries	O
in	O
the	O
series	O
.	O
</s>
<s>
The	O
game	O
is	O
set	O
three	O
years	O
after	O
the	O
events	O
of	O
Under	O
the	O
Knife	O
when	O
Doctor	O
Derek	O
Stiles	O
of	O
Caduceus	B-Application
eradicated	O
a	O
man-made	O
disease	O
called	O
GUILT	O
created	O
by	O
the	O
Delphi	O
terrorist	O
group	O
.	O
</s>
<s>
After	O
this	O
,	O
Stiles	O
and	O
Angie	O
are	O
recalled	O
to	O
Caduceus	B-Application
to	O
treat	O
a	O
new	O
GUILT-related	O
disease	O
called	O
Post-GUILT	O
Syndrome	O
,	O
a	O
series	O
of	O
critical	O
conditions	O
that	O
affect	O
any	O
patients	O
with	O
past	O
GUILT	O
exposure	O
.	O
</s>
<s>
Caduceus	B-Application
are	O
aided	O
in	O
their	O
efforts	O
against	O
GUILT	O
by	O
a	O
company	O
called	O
Acropolis	O
and	O
their	O
medical	O
arm	O
the	O
Hands	O
of	O
Asclepius	O
(	O
HOA	O
)	O
.	O
</s>
<s>
Acropolis	O
and	O
the	O
HOA	O
quickly	O
gain	O
ground	O
in	O
government	O
circles	O
due	O
to	O
creating	O
an	O
artificial	O
Healing	O
Touch	O
;	O
while	O
Caduceus	B-Application
is	O
wary	O
of	O
the	O
emotionless	O
attitudes	O
of	O
HOA	O
surgeons	O
with	O
this	O
ability	O
,	O
governments	O
throw	O
their	O
support	O
behind	O
HOA	O
to	O
the	O
detriment	O
of	O
Caduceus	B-Application
.	O
</s>
<s>
Caduceus	B-Application
then	O
confirms	O
HOA	O
's	O
shady	O
dealings	O
when	O
athletes	O
show	O
infection	O
from	O
new	O
GUILT	O
strains	O
dubbed	O
Neo-GUILT	O
;	O
HOA	O
has	O
been	O
using	O
GUILT	O
samples	O
to	O
develop	O
performance-enhancing	O
medicines	O
.	O
</s>
<s>
In	O
the	O
end	O
,	O
Blackwell	O
—	O
who	O
was	O
released	O
and	O
planted	O
inside	O
Acropolis	O
by	O
Caduceus	B-Application
executives	O
—	O
reveals	O
that	O
HOA	O
doctors	O
are	O
also	O
taking	O
this	O
medication	O
,	O
giving	O
them	O
their	O
abilities	O
while	O
infecting	O
them	O
with	O
Neo-GUILT	O
.	O
</s>
<s>
With	O
this	O
evidence	O
,	O
Caduceus	B-Application
and	O
the	O
authorities	O
storm	O
Acropolis	O
,	O
with	O
Stiles	O
curing	O
multiple	O
doctors	O
of	O
Neo-GUILT	O
infection	O
including	O
Tulba	O
.	O
</s>
<s>
Caduceus	B-Application
's	O
reputation	O
is	O
restored	O
,	O
Tulba	O
returns	O
to	O
Costigar	O
to	O
continue	O
helping	O
as	O
a	O
doctor	O
,	O
Heather	O
looks	O
after	O
Tracy	O
while	O
studying	O
to	O
be	O
a	O
nurse	O
,	O
and	O
Stiles	O
and	O
Angie	O
travel	O
abroad	O
and	O
begin	O
a	O
relationship	O
.	O
</s>
<s>
Under	B-Application
The	I-Application
Knife	I-Application
2	I-Application
was	O
produced	O
as	O
a	O
response	O
to	O
perceived	O
player	O
discomfort	O
about	O
the	O
change	O
in	O
consoles	O
from	O
the	O
DS	B-Device
with	O
Under	O
the	O
Knife	O
to	O
the	B-Operating_System
Wii	I-Operating_System
for	O
subsequent	O
entries	O
.	O
</s>
<s>
While	O
the	O
team	O
had	O
continued	O
the	O
overarching	O
narrative	O
of	O
Trauma	O
Center	O
using	O
New	B-Application
Blood	I-Application
,	O
Under	B-Application
the	I-Application
Knife	I-Application
2	I-Application
was	O
created	O
as	O
a	O
true	O
sequel	O
to	O
the	O
original	O
in	O
both	O
story	O
and	O
mechanics	O
.	O
</s>
<s>
The	O
game	O
was	O
co-directed	O
by	O
Daisuke	O
Kanada	O
,	O
series	O
director	O
since	O
Trauma	B-Application
Center	I-Application
:	I-Application
Second	I-Application
Opinion	I-Application
,	O
and	O
Hirokazu	O
Toyama	O
of	O
Vanguard	O
.	O
</s>
<s>
The	O
character	O
designs	O
were	O
created	O
by	O
Masayuki	O
Doi	O
,	O
who	O
had	O
worked	O
on	O
both	O
Second	O
Opinion	O
and	O
New	B-Application
Blood	I-Application
.	O
</s>
<s>
Under	B-Application
the	I-Application
Knife	I-Application
2	I-Application
was	O
Toyama	O
's	O
debut	O
as	O
a	O
game	O
director	O
.	O
</s>
<s>
A	O
new	O
addition	O
compared	O
to	O
the	O
original	O
DS	B-Device
version	O
were	O
more	O
voice	O
clips	O
for	O
characters	O
,	O
and	O
the	O
"	O
Easy	O
"	O
mode	O
.	O
</s>
<s>
While	O
Trauma	O
Center	O
series	O
composer	O
Kenichi	O
Tsuchiya	O
was	O
contacted	O
about	O
working	O
on	O
Under	B-Application
the	I-Application
Knife	I-Application
2	I-Application
,	O
his	O
other	O
work	O
at	O
the	O
time	O
prevented	O
him	O
from	O
taking	O
part	O
,	O
leading	O
to	O
Basiscape	O
being	O
brought	O
on	O
board	O
.	O
</s>
<s>
Due	O
to	O
having	O
access	O
to	O
advanced	O
composition	O
software	O
for	O
the	O
DS	B-Device
sound	O
environment	O
,	O
the	O
quality	O
of	O
the	O
music	O
increased	O
markedly	O
over	O
that	O
of	O
the	O
original	O
Trauma	O
Center	O
.	O
</s>
<s>
Neither	O
composer	O
had	O
worked	O
with	O
the	O
series	O
before	O
;	O
Namiki	O
had	O
previously	O
worked	O
on	O
Tekken	O
:	O
Blood	O
Vengeance	O
,	O
while	O
Kamikura	O
was	O
known	O
for	O
Muramasa	B-Application
:	I-Application
The	I-Application
Demon	I-Application
Blade	I-Application
.	O
</s>
<s>
Namiki	O
wrote	O
his	O
themes	O
to	O
express	O
saving	O
lives	O
in	O
an	O
exciting	O
scenario	O
,	O
and	O
take	O
advantage	O
of	O
the	O
DS	B-Device
's	O
sound	O
and	O
control	O
elements	O
.	O
</s>
<s>
Under	B-Application
the	I-Application
Knife	I-Application
2	I-Application
is	O
the	O
fourth	O
game	O
in	O
the	O
Trauma	O
Center	O
series	O
,	O
and	O
the	O
second	O
and	O
last	O
produced	O
for	O
the	O
DS	B-Device
.	O
</s>
<s>
When	O
speaking	O
about	O
a	O
remake	O
of	O
Under	B-Application
the	I-Application
Knife	I-Application
2	I-Application
for	O
the	B-Operating_System
Wii	I-Operating_System
similar	O
to	O
Second	O
Opinion	O
,	O
Atlus	O
USA	O
said	O
that	O
taking	O
a	O
game	O
"	O
back	O
and	O
forth	O
"	O
between	O
the	O
DS	B-Device
and	O
Wii	B-Operating_System
did	O
not	O
fit	O
in	O
with	O
Atlus	O
's	O
business	O
model	O
.	O
</s>
<s>
Under	B-Application
the	I-Application
Knife	I-Application
2	I-Application
saw	O
no	O
release	O
in	O
Europe	O
.	O
</s>
<s>
Under	B-Application
the	I-Application
Knife	I-Application
2	I-Application
failed	O
to	O
appear	O
in	O
Japanese	O
sales	O
charts	O
for	O
either	O
2008	O
or	O
2009	O
.	O
</s>
<s>
The	O
game	O
was	O
nominated	O
for	O
Best	O
Action	O
Game	O
on	O
the	O
DS	B-Device
in	O
IGNs	O
2008	O
video	O
game	O
awards	O
.	O
</s>
<s>
GameSpots	O
Shiva	O
Stella	O
said	O
that	O
Under	B-Application
the	I-Application
Knife	I-Application
2	I-Application
"	O
successfully	O
blends	O
a	O
creative	O
medical	O
theme	O
with	O
bizarre	O
but	O
fun	O
puzzle	O
gameplay	O
to	O
create	O
an	O
addictive	O
treat	O
"	O
.	O
</s>
<s>
IGNs	O
Mark	O
Bozon	O
gave	O
high	O
praise	O
to	O
the	O
story	O
and	O
gameplay	O
,	O
but	O
felt	O
it	O
lacked	O
content	O
and	O
replay	O
value	O
found	O
in	O
New	B-Application
Blood	I-Application
.	O
</s>
<s>
Fitch	O
was	O
particularly	O
negative	O
about	O
the	O
translation	O
,	O
calling	O
it	O
inferior	O
to	O
the	O
localizations	O
of	O
Persona	B-Application
3	I-Application
and	O
Odin	B-Application
Sphere	I-Application
.	O
</s>
