<s>
Trauma	B-Application
Center	I-Application
:	I-Application
Under	I-Application
the	I-Application
Knife	I-Application
is	O
a	O
simulation	O
video	O
game	O
developed	O
by	O
Atlus	O
for	O
the	O
Nintendo	B-Device
DS	I-Device
.	O
</s>
<s>
Doctor	O
Derek	O
Stiles	O
,	O
a	O
surgeon	O
possessing	O
a	O
mystical	O
"	O
Healing	O
Touch	O
"	O
,	O
works	O
with	O
the	O
medical	O
group	O
Caduceus	B-Application
to	O
find	O
a	O
cure	O
to	O
GUILT	O
.	O
</s>
<s>
The	O
gameplay	O
combines	O
surgery-based	O
simulation	O
relying	O
on	O
the	O
DS	B-Device
's	O
touchscreen	O
controls	O
with	O
a	O
story	O
told	O
as	O
a	O
visual	O
novel	O
.	O
</s>
<s>
Designed	O
to	O
take	O
advantage	O
of	O
the	O
DS	B-Device
's	O
control	O
options	O
after	O
planned	O
development	O
for	O
earlier	O
consoles	O
stalled	O
due	O
to	O
inadequate	O
hardware	O
,	O
development	O
lasted	O
just	O
over	O
a	O
year	O
.	O
</s>
<s>
Development	O
proved	O
challenging	O
for	O
the	O
staff	O
,	O
who	O
were	O
veterans	O
of	O
the	O
Megami	B-Application
Tensei	I-Application
franchise	O
and	O
had	O
little	O
experience	O
with	O
genres	O
outside	O
role-playing	O
.	O
</s>
<s>
The	O
game	O
was	O
positively	O
reviewed	O
by	O
journalists	O
,	O
who	O
praised	O
the	O
title	O
for	O
its	O
use	O
of	O
the	O
DS	B-Device
controls	O
while	O
criticising	O
its	O
difficulty	O
spikes	O
and	O
repetition	O
.	O
</s>
<s>
A	O
remake	O
for	O
the	B-Operating_System
Wii	I-Operating_System
,	O
Trauma	B-Application
Center	I-Application
:	I-Application
Second	I-Application
Opinion	I-Application
,	O
released	O
the	O
following	O
year	O
.	O
</s>
<s>
A	O
DS	B-Device
sequel	O
,	O
Under	B-Application
the	I-Application
Knife	I-Application
2	I-Application
,	O
was	O
released	O
in	O
2008	O
.	O
</s>
<s>
Trauma	B-Application
Center	I-Application
:	I-Application
Under	I-Application
the	I-Application
Knife	I-Application
is	O
a	O
video	O
game	O
that	O
combines	O
surgical	O
simulation	O
gameplay	O
with	O
storytelling	O
using	O
non-interactive	O
visual	O
novel	O
segments	O
using	O
static	O
scenes	O
,	O
character	O
portraits	O
,	O
text	O
boxes	O
,	O
and	O
voice	O
clips	O
during	O
gameplay	O
segments	O
.	O
</s>
<s>
The	O
top	O
screen	O
of	O
the	O
Nintendo	B-Device
DS	I-Device
is	O
dedicated	O
to	O
story	O
sequences	O
and	O
level	O
statistics	O
displayed	O
as	O
2D	O
artwork	O
,	O
while	O
the	O
bottom	O
touch	O
screen	O
is	O
dedicated	O
to	O
the	O
operations	O
themselves	O
rendered	O
using	O
3D	O
models	O
.	O
</s>
<s>
All	O
of	O
these	O
actions	O
are	O
accomplished	O
using	O
the	O
DS	B-Device
stylus	O
.	O
</s>
<s>
The	O
world	O
's	O
pioneering	O
medical	O
organization	O
is	O
Caduceus	B-Application
,	O
a	O
semi-covert	O
group	O
dedicated	O
to	O
curing	O
intractable	O
diseases	O
.	O
</s>
<s>
After	O
treating	O
another	O
patient	O
infected	O
with	O
an	O
unknown	O
parasitic	O
disease	O
,	O
Stiles	O
is	O
offered	O
a	O
position	O
at	O
Caduceus	B-Application
,	O
which	O
he	O
accepts	O
.	O
</s>
<s>
During	O
their	O
work	O
,	O
several	O
Caduceus	B-Application
staff	O
members	O
are	O
infected	O
,	O
including	O
the	O
director	O
,	O
Richard	O
Anderson	O
.	O
</s>
<s>
During	O
an	O
attempted	O
raid	O
by	O
Delphi	O
on	O
Caduceus	B-Application
,	O
the	O
intruder	O
is	O
identified	O
as	O
Angie	O
's	O
father	O
Kenneth	O
Blackwell	O
.	O
</s>
<s>
Once	O
cured	O
,	O
Blackwell	O
offers	O
his	O
full	O
cooperation	O
and	O
rejects	O
Caduceus	B-Application
's	O
offer	O
of	O
amnesty	O
,	O
wishing	O
to	O
serve	O
out	O
his	O
term	O
in	O
prison	O
to	O
atone	O
for	O
his	O
actions	O
.	O
</s>
<s>
When	O
Stiles	O
and	O
Angie	O
assist	O
with	O
a	O
raid	O
in	O
cooperation	O
with	O
Caduceus	B-Application
Europe	O
,	O
they	O
find	O
that	O
Delphi	O
has	O
been	O
using	O
children	O
to	O
incubate	O
GUILT	O
,	O
and	O
after	O
curing	O
the	O
patients	O
,	O
they	O
encounter	O
Delphi	O
's	O
leader	O
,	O
Adam	O
,	O
now	O
a	O
vegetable	O
host	O
for	O
all	O
seven	O
strains	O
of	O
GUILT	O
,	O
as	O
well	O
as	O
a	O
unique	O
,	O
eighth	O
strain	O
known	O
as	O
"	O
Bliss.	O
"	O
</s>
<s>
Caduceus	B-Application
Europe	O
impound	O
Adam	O
's	O
remains	O
,	O
and	O
Stiles	O
is	O
hailed	O
for	O
his	O
actions	O
.	O
</s>
<s>
This	O
changed	O
with	O
internal	O
previewing	O
of	O
the	O
DS	B-Device
,	O
which	O
had	O
the	O
controls	O
and	O
functions	O
to	O
make	O
the	O
simulation	O
elements	O
work	O
as	O
intended	O
.	O
</s>
<s>
Most	O
of	O
the	O
staff	O
were	O
veterans	O
of	O
Atlus	O
's	O
Megami	B-Application
Tensei	I-Application
role-playing	O
video	O
game	O
(	O
RPG	O
)	O
franchise	O
,	O
making	O
the	O
development	O
a	O
difficult	O
one	O
due	O
to	O
its	O
thematic	O
and	O
gameplay	O
differences	O
.	O
</s>
<s>
The	O
scenario	O
was	O
written	O
by	O
Shogo	O
Isogai	O
,	O
who	O
faced	O
problems	O
when	O
creating	O
a	O
narrative	O
that	O
would	O
be	O
respectful	O
towards	O
the	O
medical	O
profession	O
while	O
being	O
fun	O
,	O
and	O
confront	O
very	O
different	O
themes	O
to	O
his	O
work	O
on	O
the	O
Megami	B-Application
Tensei	I-Application
series	O
.	O
</s>
<s>
The	O
team	O
needed	O
to	O
think	O
carefully	O
about	O
the	O
naming	O
of	O
GUILT	O
strains	O
,	O
which	O
were	O
all	O
derived	O
from	O
Greek	O
words	O
,	O
which	O
sharply	O
contrasted	O
their	O
free	O
borrowing	O
of	O
demon	O
names	O
for	O
the	O
Megami	B-Application
Tensei	I-Application
series	O
.	O
</s>
<s>
Meguro	O
and	O
Tsuchiya	O
were	O
both	O
veterans	O
of	O
the	O
Megami	B-Application
Tensei	I-Application
franchise	O
,	O
particularly	O
its	O
Persona	O
and	O
Devil	B-Application
Summoner	I-Application
subseries	O
.	O
</s>
<s>
While	O
Meguro	O
and	O
Kikkawa	O
composed	O
standard-definition	O
music	O
and	O
reduced	O
it	O
to	O
fit	O
into	O
the	O
DS	B-Device
sound	O
environment	O
,	O
Tsuchiya	O
composed	O
his	O
tracks	O
within	O
the	O
sound	O
environment	O
.	O
</s>
<s>
At	O
the	O
time	O
,	O
Atlus	O
did	O
not	O
have	O
a	O
MIDI	O
interface	O
for	O
DS	B-Device
composition	O
,	O
so	O
the	O
composers	O
had	O
to	O
guess	O
what	O
the	O
sound	O
would	O
be	O
like	O
when	O
transplanted	O
into	O
the	O
game	O
.	O
</s>
<s>
The	O
game	O
was	O
first	O
announced	O
in	O
July	O
2004	O
alongside	O
five	O
other	O
Atlus	O
titles	O
for	O
the	O
DS	B-Device
.	O
</s>
<s>
Derek	O
Stiles	O
's	O
English	O
name	O
was	O
written	O
as	O
a	O
pun	O
on	O
the	O
word	O
"	O
stylus	O
"	O
,	O
referencing	O
the	O
DS	B-Device
stylus	O
.	O
</s>
<s>
The	O
English	O
dub	O
was	O
handled	O
by	O
PCP	O
Productions	O
,	O
who	O
had	O
previously	O
worked	O
with	O
Atlus	O
on	O
Shin	B-Application
Megami	I-Application
Tensei	I-Application
:	I-Application
Digital	I-Application
Devil	I-Application
Saga	I-Application
.	O
</s>
<s>
Famitsu	O
praised	O
the	O
game	O
's	O
innovative	O
use	O
of	O
the	O
touch	O
screen	O
,	O
while	O
Christian	O
Nutt	O
of	O
1UP.com	O
called	O
the	O
game	O
a	O
standout	O
title	O
for	O
the	O
DS	B-Device
due	O
to	O
its	O
polished	O
controls	O
and	O
unconventional	O
premise	O
.	O
</s>
<s>
GamePro	O
called	O
the	O
game	O
"	O
a	O
cure	O
for	O
what	O
has	O
been	O
a	O
spell	O
of	O
mediocrity	O
on	O
the	O
DS	B-Device
"	O
.	O
</s>
<s>
The	O
use	O
of	O
the	O
DS	B-Device
touch	O
screen	O
and	O
stylus	O
were	O
generally	O
lauded	O
by	O
critics	O
;	O
East	O
called	O
it	O
a	O
concept	O
only	O
made	O
possible	O
by	O
the	O
hardware	O
,	O
while	O
Leeper	O
had	O
issues	O
with	O
stylus	O
motions	O
registering	O
.	O
</s>
<s>
In	O
a	O
feature	O
by	O
Jess	O
Ragan	O
for	O
1UP.com,	O
Trauma	B-Application
Center	I-Application
:	I-Application
Under	I-Application
the	I-Application
Knife	I-Application
was	O
described	O
as	O
having	O
"	O
helped	O
pull	O
the	O
Nintendo	B-Device
DS	I-Device
out	O
of	O
a	O
debilitating	O
software	O
drought	O
and	O
demonstrated	O
the	O
system	O
's	O
potential	O
to	O
both	O
hardcore	O
gamers	O
and	O
skeptical	O
outsiders	O
alike	O
"	O
.	O
</s>
<s>
The	O
Trauma	O
Center	O
series	O
would	O
be	O
continued	O
with	O
three	O
subsequent	O
games	O
on	O
Nintendo	O
hardware	O
;	O
Trauma	B-Application
Center	I-Application
:	I-Application
New	I-Application
Blood	I-Application
for	O
the	B-Operating_System
Wii	I-Operating_System
in	O
2007	O
,	O
the	O
direct	O
sequel	O
Trauma	B-Application
Center	I-Application
:	I-Application
Under	I-Application
the	I-Application
Knife	I-Application
2	I-Application
,	O
released	O
in	O
2008	O
for	O
the	O
DS	B-Device
;	O
and	O
Trauma	B-Application
Team	I-Application
for	O
the	B-Operating_System
Wii	I-Operating_System
in	O
2010	O
.	O
</s>
<s>
A	O
remake	O
of	O
Under	O
the	O
Knife	O
,	O
Trauma	B-Application
Center	I-Application
:	I-Application
Second	I-Application
Opinion	I-Application
,	O
was	O
released	O
for	O
the	B-Operating_System
Wii	I-Operating_System
in	O
2006	O
as	O
a	O
launch	O
title	O
for	O
the	O
console	O
.	O
</s>
