<s>
Transmission	B-Algorithm
Raman	I-Algorithm
spectroscopy	I-Algorithm
(	O
TRS	O
)	O
is	O
a	O
variant	O
of	O
Raman	B-Algorithm
spectroscopy	I-Algorithm
which	O
is	O
advantageous	O
in	O
probing	O
bulk	O
content	O
of	O
diffusely	O
scattering	O
samples	O
.	O
</s>
<s>
Although	O
it	O
was	O
demonstrated	O
in	O
the	O
early	O
days	O
of	O
Raman	B-Algorithm
spectroscopy	I-Algorithm
it	O
was	O
not	O
exploited	O
in	O
practical	O
settings	O
until	O
much	O
later	O
,	O
probably	O
due	O
to	O
limitations	O
of	O
technology	O
at	O
the	O
time	O
.	O
</s>
<s>
It	O
was	O
rediscovered	O
in	O
2006	O
,	O
where	O
the	O
authors	O
showed	O
that	O
it	O
was	O
capable	O
of	O
allowing	O
Raman	B-Algorithm
spectroscopy	I-Algorithm
through	O
many	O
millimetres	O
of	O
tabletted	O
or	O
powdered	O
samples	O
.	O
</s>
<s>
Transmission	B-Algorithm
Raman	I-Algorithm
is	O
possible	O
because	O
light	O
scatters	O
through	O
turbid	O
materials	O
that	O
do	O
not	O
significantly	O
absorb	O
or	O
block	O
the	O
light	O
.	O
</s>
<s>
By	O
a	O
similar	O
mechanism	O
to	O
spatially	B-Algorithm
offset	I-Algorithm
Raman	I-Algorithm
spectroscopy	I-Algorithm
,	O
the	O
light	O
in	O
a	O
diffusely	O
scattering	O
sample	O
spreads	O
through	O
the	O
object	O
randomly	O
(	O
Transmission	B-Algorithm
Raman	I-Algorithm
can	O
be	O
regarded	O
as	O
an	O
extreme	O
example	O
of	O
SORS	O
)	O
.	O
</s>
<s>
This	O
desirable	O
property	O
removes	O
a	O
problem	O
with	O
conventional	O
,	O
widely	O
used	O
back-scattering	O
Raman	B-Algorithm
spectroscopy	I-Algorithm
where	O
the	O
signal	O
tends	O
to	O
be	O
representative	O
of	O
the	O
surface	O
and	O
near-surface	O
composition	O
.	O
</s>
<s>
Because	O
Raman	B-Algorithm
spectroscopy	I-Algorithm
does	O
not	O
rely	O
on	O
absorption	O
and	O
the	O
light	O
spreads	O
throughout	O
the	O
sample	O
,	O
a	O
large	O
thickness	O
can	O
be	O
measured	O
in	O
the	O
absence	O
of	O
photon	O
absorption	O
.	O
</s>
<s>
Transmission	B-Algorithm
Raman	I-Algorithm
lends	O
itself	O
to	O
rapid	O
,	O
non-invasive	O
and	O
non-destructive	O
analysis	O
of	O
pharmaceutical	O
dosage	O
forms	O
such	O
as	O
capsules	O
and	O
tablets	O
.	O
</s>
<s>
Transmission	B-Algorithm
Raman	I-Algorithm
is	O
largely	O
insensitive	O
to	O
surface	O
,	O
requires	O
no	O
sample	O
preparation	O
,	O
involves	O
no	O
phase	O
change	O
and	O
is	O
rapid	O
.	O
</s>
<s>
Transmission	B-Algorithm
Raman	I-Algorithm
spectroscopy	I-Algorithm
of	O
pharmaceutical	O
tablets	O
and	O
capsules	O
was	O
first	O
demonstrated	O
by	O
Matousek	O
and	O
Parker	O
.	O
</s>
<s>
Transmission	B-Algorithm
Raman	I-Algorithm
spectroscopy	I-Algorithm
can	O
be	O
used	O
as	O
a	O
process	O
analytical	O
technology	O
(	O
PAT	O
)	O
tool	O
for	O
the	O
detection	O
of	O
physical	O
state	O
of	O
the	O
API	O
and	O
for	O
obtaining	O
qualitative	O
and	O
quantitative	O
information	O
about	O
the	O
composition	O
.	O
</s>
<s>
The	O
use	O
of	O
Raman	B-Algorithm
spectroscopy	I-Algorithm
in	O
medical	O
applications	O
has	O
been	O
limited	O
to	O
depths	O
of	O
hundreds	O
of	O
micrometres	O
(	O
confocal	O
Raman	O
)	O
.	O
</s>
<s>
Transmission	B-Algorithm
Raman	I-Algorithm
has	O
been	O
demonstrated	O
as	O
a	O
potential	O
diagnostic	O
tool	O
for	O
lesions	O
in	O
breast	O
tissue	O
.	O
</s>
