<s>
Tomoelastography	B-Algorithm
(	O
from	O
ancient	O
Greek	O
τόμος	O
tomos	O
,	O
“	O
slice	O
”	O
and	O
elastography	B-Algorithm
–	O
imaging	O
of	O
viscoelastic	O
properties	O
)	O
is	O
a	O
medical	B-Application
imaging	I-Application
technique	I-Application
that	O
provides	O
quantitative	O
maps	O
of	O
the	O
mechanical	O
properties	O
of	O
biological	O
soft	O
tissues	O
with	O
high	O
spatial	O
resolution	O
(	O
called	O
elastograms	O
)	O
.	O
</s>
<s>
It	O
is	O
an	O
advancement	O
of	O
elastography	B-Algorithm
in	O
that	O
it	O
generates	O
unmasked	O
maps	O
of	O
stiffness	B-Algorithm
and	O
viscosity	O
across	O
the	O
entire	O
field	O
of	O
view	O
that	O
can	O
be	O
captured	O
with	O
a	O
given	O
imaging	O
modality	O
.	O
</s>
<s>
Medical	B-Application
ultrasound	I-Application
and	O
magnetic	O
resonance	O
imaging	O
(	O
MRI	O
)	O
are	O
the	O
most	O
commonly	O
used	O
imaging	O
modalities	O
for	O
elastography	B-Algorithm
.	O
</s>
<s>
Classical	O
elastography	B-Algorithm
only	O
measures	O
stiffness	B-Algorithm
in	O
a	O
limited	O
region	O
,	O
such	O
as	O
at	O
a	O
depth	O
of	O
6cm	O
in	O
the	O
liver	O
or	O
in	O
a	O
selected	O
liver	O
lobe	O
,	O
and	O
thus	O
cannot	O
provide	O
an	O
overview	O
of	O
the	O
adjacent	O
tissues	O
or	O
organs	O
.	O
</s>
<s>
Tomoelastography	B-Algorithm
,	O
on	O
the	O
other	O
hand	O
,	O
is	O
a	O
radiological	B-Application
imaging	I-Application
method	O
that	O
allows	O
estimation	O
of	O
quantitative	O
mechanical	O
parameters	O
of	O
all	O
organs	O
and	O
structures	O
in	O
the	O
field	O
of	O
view	O
.	O
</s>
<s>
Moreover	O
,	O
tomoelastography	B-Algorithm
does	O
not	O
rely	O
on	O
a	O
single	O
,	O
specific	O
imaging	O
modality	O
.	O
</s>
<s>
While	O
it	O
has	O
been	O
introduced	O
and	O
is	O
mostly	O
performed	O
using	O
magnetic	B-Algorithm
resonance	I-Algorithm
elastography	I-Algorithm
(	O
MRE	B-Algorithm
)	O
,	O
tomoelastography	B-Algorithm
can	O
be	O
extended	O
to	O
other	O
imaging	O
techniques	O
as	O
well	O
.	O
</s>
<s>
Tomoelastography	B-Algorithm
requires	O
external	O
driver	O
systems	O
,	O
which	O
can	O
efficiently	O
generate	O
shear	O
waves	O
throughout	O
the	O
entire	O
field	O
of	O
view	O
including	O
tissues	O
deep	O
within	O
the	O
body	O
.	O
</s>
<s>
Tomoelastography	B-Algorithm
often	O
employs	O
mechanical	O
vibrations	O
at	O
several	O
driving	O
frequencies	O
for	O
multifrequency	O
wave	O
analysis	O
in	O
order	O
to	O
stabilize	O
inverse	O
problem	O
solutions	O
for	O
viscoelasticity	O
reconstructions	O
.	O
</s>
<s>
The	O
feasibility	O
of	O
tomoelastography	B-Algorithm
was	O
first	O
demonstrated	O
in	O
the	O
human	O
abdomen	O
using	O
multifrequency	O
MRE	B-Algorithm
,	O
where	O
it	O
was	O
possible	O
for	O
the	O
first	O
time	O
to	O
display	O
stiffness	B-Algorithm
values	O
(	O
quantified	O
as	O
shear	O
wave	O
speed	O
in	O
m/s	O
)	O
across	O
the	O
entire	O
axial	O
MRI	O
slice	O
.	O
</s>
<s>
Although	O
the	O
elastograms	O
are	O
quantitative	O
maps	O
,	O
tomoelastography	B-Algorithm
images	O
,	O
like	O
other	O
radiological	O
images	O
,	O
are	O
often	O
presented	O
in	O
standard	O
gray-scale	O
which	O
gives	O
more	O
perceptual	O
contrast	O
to	O
the	O
subtle	O
nuances	O
than	O
the	O
color-scale	O
.	O
</s>
<s>
Currently	O
,	O
most	O
applications	O
of	O
tomoelastography	B-Algorithm
are	O
based	O
on	O
MRI	O
,	O
which	O
is	O
why	O
tomoelastography	B-Algorithm
is	O
often	O
referred	O
to	O
as	O
an	O
advanced	O
MRE	B-Algorithm
technique	O
.	O
</s>
<s>
Multifrequency-MRE	O
based	O
tomoelastography	B-Algorithm
has	O
been	O
used	O
for	O
the	O
diagnosis	O
of	O
diffuse	O
liver	O
disease	O
,	O
renal	O
diseases	O
such	O
as	O
renal	O
allograft	O
dysfunction	O
,	O
lupus	O
nephritis	O
,	O
and	O
immunoglobulin	O
A	O
nephropathy	O
(	O
IgAN	O
)	O
.	O
</s>
<s>
In	O
addition	O
,	O
tomoelastography	B-Algorithm
has	O
been	O
used	O
for	O
cancer	O
imaging	O
.	O
</s>
<s>
In	O
the	O
prostate	O
,	O
tomoelastography	B-Algorithm
has	O
been	O
able	O
to	O
distinguish	O
cancer	O
from	O
benign	O
lesions	O
.	O
</s>
