<s>
SimpleITK	B-Language
is	O
a	O
simplified	O
,	O
open-source	B-Application
interface	O
to	O
the	O
Insight	B-Language
Segmentation	I-Language
and	I-Language
Registration	I-Language
Toolkit	I-Language
(	O
ITK	B-Language
)	O
.	O
</s>
<s>
The	O
SimpleITK	B-Language
image	B-General_Concept
analysis	I-General_Concept
library	O
is	O
available	O
in	O
multiple	O
programming	O
languages	O
including	O
C++	B-Language
,	O
Python	B-Language
,	O
R	B-Language
,	O
Java	B-Language
,	O
C#	B-Application
,	O
Lua	B-Language
,	O
Ruby	B-Language
and	O
Tcl	B-Operating_System
.	O
</s>
<s>
Binary	O
distributions	O
are	O
available	O
for	O
all	O
three	O
major	O
operating	O
systems	O
(	O
Linux	B-Application
,	O
macOS	B-Application
and	O
Microsoft	B-Application
Windows	I-Application
)	O
.	O
</s>
<s>
Developed	O
at	O
the	O
National	O
Institutes	O
of	O
Health	O
(	O
NIH	O
)	O
as	O
an	O
open	O
resource	O
,	O
its	O
primary	O
goal	O
is	O
to	O
make	O
the	O
algorithms	O
available	O
in	O
the	O
ITK	B-Language
library	O
accessible	O
to	O
the	O
broadest	O
range	O
of	O
scientists	O
whose	O
work	O
includes	O
image	B-General_Concept
analysis	I-General_Concept
,	O
irrespective	O
of	O
their	O
software	O
development	O
skills	O
.	O
</s>
<s>
As	O
a	O
consequence	O
,	O
the	O
SimpleITK	B-Language
interface	O
exposes	O
only	O
the	O
most	O
commonly	O
modified	O
algorithmic	O
settings	O
of	O
the	O
ITK	B-Language
components	O
.	O
</s>
<s>
Additionally	O
,	O
the	O
library	O
provides	O
both	O
an	O
object	B-Language
oriented	I-Language
and	O
a	O
procedural	B-Application
interface	O
to	O
most	O
of	O
the	O
image	O
processing	O
filters	O
.	O
</s>
<s>
The	O
latter	O
enables	O
image	B-General_Concept
analysis	I-General_Concept
workflows	O
with	O
concise	O
syntax	O
.	O
</s>
<s>
A	O
secondary	O
goal	O
of	O
the	O
library	O
is	O
to	O
promote	O
reproducible	O
image	B-General_Concept
analysis	I-General_Concept
workflows	O
by	O
using	O
the	O
SimpleITK	B-Language
library	O
in	O
conjunction	O
with	O
modern	O
tools	O
for	O
reproducible	O
computational	O
workflows	O
available	O
in	O
the	O
Python	B-Language
(	O
Jupyter	B-Application
notebooks	I-Application
)	O
and	O
R	B-Language
(	O
knitr	B-Application
package	I-Application
)	O
programming	O
languages	O
.	O
</s>
<s>
Software	O
development	O
is	O
centered	O
on	O
GitHub	B-Application
using	O
a	O
fork	B-Application
and	I-Application
pull	I-Application
model	I-Application
.	O
</s>
<s>
The	O
project	O
is	O
built	O
using	O
the	O
CMake	B-Language
tool	O
,	O
with	O
nightly	O
builds	O
posted	O
to	O
the	O
.	O
</s>
<s>
Multiple	O
medical	O
image	B-General_Concept
analysis	I-General_Concept
applications	O
and	O
libraries	O
incorporate	O
SimpleITK	B-Language
as	O
a	O
key	O
building	O
block	O
,	O
as	O
it	O
provides	O
a	O
wide	O
range	O
of	O
image	O
filtering	O
and	O
image	O
IO	O
components	O
with	O
a	O
user	O
friendly	O
interface	O
.	O
</s>
<s>
Examples	O
include	O
the	O
pyOsirix	O
scripting	O
tool	O
for	O
the	O
popular	O
Osirix	O
application	O
,	O
the	O
pyradiomics	O
python	B-Language
package	O
for	O
extracting	O
radiomic	O
features	O
from	O
medical	O
imaging	O
,	O
the	O
3DSlicer	B-Application
image	B-General_Concept
analysis	I-General_Concept
application	O
,	O
the	O
SimpleElastix	O
medical	O
image	O
registration	O
library	O
,	O
and	O
the	O
NiftyNet	O
deep	O
learning	O
library	O
for	O
medical	O
imaging	O
.	O
</s>
<s>
The	O
initial	O
development	O
of	O
SimpleITK	B-Language
was	O
funded	O
by	O
the	O
United	O
States	O
National	O
Library	O
of	O
Medicine	O
under	O
the	O
American	O
Recovery	O
and	O
Reinvestment	O
Act	O
(	O
ARRA	O
)	O
program	O
as	O
a	O
collaboration	O
between	O
The	O
Mayo	O
Clinic	O
,	O
Kitware	O
Inc	O
,	O
The	O
University	O
of	O
Iowa	O
and	O
NLM	O
's	O
intramural	O
program	O
.	O
</s>
<s>
Between	O
2013	O
and	O
2019	O
,	O
SimpleITK	B-Language
development	O
was	O
primarily	O
carried	O
out	O
as	O
part	O
of	O
the	O
intramural	O
research	O
program	O
of	O
the	O
National	O
Library	O
of	O
Medicine	O
with	O
collaborators	O
at	O
The	O
University	O
of	O
Iowa	O
and	O
Monash	O
University	O
.	O
</s>
<s>
Since	O
2019	O
,	O
SimpleITK	B-Language
development	O
is	O
primarily	O
carried	O
out	O
under	O
the	O
Office	O
of	O
Cyber	O
Infrastructure	O
and	O
Computational	O
Biology	O
at	O
the	O
National	O
Institute	O
of	O
Allergy	O
and	O
Infectious	O
Diseases	O
.	O
</s>
<s>
Short	O
Python	B-Language
scripts	I-Language
illustrating	O
image	O
reading	O
,	O
blurring	O
,	O
and	O
writing	O
.	O
</s>
<s>
Using	O
the	O
object	B-Language
oriented	I-Language
interface	O
:	O
</s>
<s>
A	O
more	O
concise	O
version	O
using	O
the	O
procedural	B-Application
interface	O
:	O
</s>
