<s>
Similarity	B-Operating_System
Matrix	I-Operating_System
of	I-Operating_System
Proteins	I-Operating_System
(	O
SIMAP	O
)	O
is	O
a	O
database	O
of	O
protein	O
similarities	O
created	O
using	O
volunteer	B-Operating_System
computing	I-Operating_System
.	O
</s>
<s>
SIMAP	O
uses	O
the	O
FASTA	B-Application
algorithm	O
to	O
precalculate	O
protein	O
similarity	O
,	O
while	O
another	O
application	O
uses	O
hidden	O
Markov	O
models	O
to	O
search	O
for	O
protein	O
domains	O
.	O
</s>
<s>
On	O
May	O
30	O
,	O
2014	O
,	O
it	O
was	O
announced	O
by	O
project	O
administrators	O
that	O
after	O
a	O
10-year	O
history	O
,	O
SIMAP	O
would	O
be	O
leaving	O
BOINC	B-Operating_System
by	O
the	O
end	O
of	O
2014	O
.	O
</s>
<s>
SIMAP	O
research	O
,	O
however	O
,	O
will	O
go	O
forward	O
with	O
the	O
use	O
of	O
local	O
hardware	O
consisting	O
of	O
"	O
ordinary	O
multi-core	O
CPUs	O
(	O
some	O
hundreds	O
)	O
,	O
crunching	O
a	O
SSE-optimized	O
version	O
of	O
the	O
Smith-Waterman	O
algorithm.	O
"	O
</s>
<s>
SIMAP	O
used	O
the	O
Berkeley	B-Operating_System
Open	I-Operating_System
Infrastructure	I-Operating_System
for	I-Operating_System
Network	I-Operating_System
Computing	I-Operating_System
(	O
BOINC	B-Operating_System
)	O
distributed	B-Architecture
computing	I-Architecture
platform	O
.	O
</s>
<s>
SIMAP	O
provided	O
client	O
software	O
optimized	O
for	O
SSE	B-General_Concept
enabled	O
processors	O
and	O
x86-64	B-Device
processors	O
.	O
</s>
<s>
For	O
older	O
processors	O
non	O
SSE	B-General_Concept
applications	O
are	O
provided	O
but	O
require	O
manual	O
installation	O
steps	O
to	O
be	O
taken	O
.	O
</s>
<s>
Operating	B-General_Concept
Systems	I-General_Concept
supported	O
by	O
SIMAP	O
are	O
Linux	B-Application
,	O
Windows	B-Application
,	O
Mac	B-Application
OS	I-Application
,	O
Android	B-Application
,	O
and	O
other	O
UNIX	O
platforms	O
.	O
</s>
