<s>
Sequerome	B-Application
is	O
a	O
web-based	O
sequence	B-Application
profiling	I-Application
tool	I-Application
for	O
integrating	O
the	O
results	O
of	O
a	O
BLAST	B-Application
sequence-alignment	O
report	O
with	O
external	O
research	O
tools	O
and	O
servers	O
that	O
perform	O
advanced	O
sequence	O
manipulations	O
,	O
and	O
allowing	O
the	O
user	O
to	O
record	O
the	O
steps	O
of	O
such	O
an	O
analysis	O
.	O
</s>
<s>
Sequerome	B-Application
is	O
a	O
web-based	O
Java	B-Device
tool	O
that	O
acts	O
as	O
a	O
front-end	O
to	O
BLAST	B-Application
queries	O
and	O
provides	O
simplified	O
access	O
to	O
web-distributed	O
resources	O
for	O
protein	O
and	O
nucleic	O
acid	O
analysis	O
.	O
</s>
<s>
In	O
a	O
single	O
browser	O
it	O
is	O
possible	O
to	O
run	O
parallel	O
BLAST	B-Application
searches	O
on	O
different	O
sequences	O
,	O
analyzing	O
them	O
or	O
viewing	O
the	O
restriction	O
digests	O
for	O
each	O
document	O
of	O
a	O
BLAST	B-Application
result	O
.	O
</s>
<s>
Sanjeev	O
Dappa	O
,	O
a	O
Tamil	O
researcher	O
criticised	O
Sequerome	B-Application
and	O
when	O
questioned	O
,	O
provided	O
no	O
further	O
details	O
.	O
</s>
<s>
The	O
user	O
has	O
to	O
just	O
dump	O
in	O
the	O
sequence	O
in	O
the	O
Query	O
pane	O
,	O
and	O
BLAST	B-Application
the	O
sequence	O
right	O
away	O
under	O
standard	O
parameters	O
.	O
</s>
<s>
Some	O
of	O
features	O
include	O
selection	O
of	O
specific	O
databases	O
to	O
BLAST	B-Application
from	O
,	O
upload	O
facility	O
to	O
work	O
with	O
FASTA	O
files	O
stored	O
in	O
individual	O
computers	O
,	O
sequence	O
retrieval	O
using	O
NCBI	O
IDs	O
and	O
visit	O
any	O
user-defined	O
URL	O
to	O
drag-N-drop	O
the	O
sequences	O
.	O
</s>
<s>
translation	O
,	O
can	O
be	O
further	O
carried	O
on	O
to	O
do	O
further	O
BLAST	B-Application
analysis	O
while	O
preserving	O
the	O
history	O
of	O
the	O
earlier	O
search	O
.	O
</s>
<s>
Sequerome	B-Application
directly	O
queries	O
the	O
input	O
sequence	O
against	O
a	O
variety	O
of	O
databases/tools	O
( 	O
 '	O
popular	O
public	O
domains	O
 '	O
and	O
'	O
privately	O
hosted	O
services	O
 '	O
)	O
including	O
BLAST	B-Application
,	O
Protein	O
Data	O
Bank	O
(	O
PDB	O
)	O
,	O
REBASE	O
and	O
others	O
,	O
and	O
generates	O
outputs	O
that	O
are	O
intuitive	O
and	O
easily	O
comprehensible	O
.	O
</s>
<s>
Access	O
to	O
various	O
analysis	O
tools	O
,	O
(	O
including	O
viewing	O
a	O
3D	O
structure-viewer	O
from	O
a	O
PDBid	O
)	O
,	O
is	O
provided	O
as	O
separate	O
command	O
buttons	O
to	O
analyze	O
every	O
record	O
from	O
a	O
BLAST	B-Application
report	O
before	O
making	O
a	O
final	O
selection	O
.	O
</s>
<s>
In	O
case	O
of	O
results	O
from	O
a	O
protein	O
BLAST	B-Application
,	O
PDBids	O
are	O
displayed	O
prominently	O
in	O
appropriate	O
cases	O
next	O
to	O
the	O
BLAST	B-Application
record	O
,	O
so	O
that	O
the	O
structure	O
of	O
the	O
molecule	O
with	O
a	O
match	O
can	O
be	O
viewed	O
directly	O
(	O
with	O
an	O
already	O
downloaded	O
version	O
of	O
molecular	O
structure	O
viewer	O
e.g.	O
,	O
Cn3D	B-Application
,	O
PyMOL	B-Application
,	O
Rasmol	O
,	O
etc	O
.	O
)	O
</s>
<s>
Once	O
the	O
BLAST	B-Application
report	O
is	O
displayed	O
on	O
the	O
Results	O
pane	O
,	O
the	O
user	O
can	O
to	O
directly	O
perform	O
an	O
analysis	O
on	O
any	O
of	O
the	O
BLAST	B-Application
hits	O
using	O
a	O
series	O
of	O
command	O
buttons	O
that	O
are	O
linked	O
to	O
the	O
respective	O
servers/	O
sites	O
.	O
</s>
<s>
Sequerome	B-Application
has	O
a	O
three-tiered	O
architecture	O
that	O
uses	O
Java	B-Application
servlet	I-Application
and	O
Server	O
Page	O
technologies	O
with	O
Java	B-Language
database	I-Language
connectivity	I-Language
(	O
JDBC	B-Language
)	O
,	O
making	O
it	O
both	O
server	O
and	O
platform-independent	O
.	O
</s>
<s>
Sequerome	B-Application
is	O
compatible	O
with	O
essentially	O
all	O
Java-enabled	O
,	O
graphical	O
browsers	O
but	O
is	O
better	O
accessed	O
using	O
Internet	B-Application
Explorer	I-Application
and	O
can	O
be	O
run	O
on	O
most	O
operating	O
systems	O
equipped	O
with	O
a	O
Java	B-Language
Virtual	I-Language
Machine	I-Language
(	O
JVM	B-Language
)	O
and	O
Jakarta	B-Language
Tomcat	I-Language
server	O
.	O
</s>
<s>
PyMOL	B-Application
,	O
Cn3D	B-Application
,	O
Rasmol	O
,	O
SwissPDB	O
,	O
etc	O
.	O
</s>
<s>
The	O
"	O
post-genomics	O
"	O
era	O
has	O
given	O
rise	O
to	O
a	O
range	O
of	O
web-based	O
tools	O
and	O
software	O
to	O
compile	O
,	O
organize	O
,	O
and	O
deliver	O
large	O
amounts	O
of	O
primary	O
sequence	O
information	O
,	O
as	O
well	O
as	O
protein	O
structures	O
,	O
gene	O
annotations	O
,	O
sequence	B-Algorithm
alignments	I-Algorithm
,	O
and	O
other	O
common	O
bioinformatics	O
tasks	O
.	O
</s>
