<s>
SCP-ISM	B-Algorithm
,	O
or	O
screened	B-Algorithm
Coulomb	I-Algorithm
potentials	I-Algorithm
implicit	I-Algorithm
solvent	I-Algorithm
model	I-Algorithm
,	O
is	O
a	O
continuum	O
approximation	O
of	O
solvent	O
effects	O
for	O
use	O
in	O
computer	B-Application
simulations	I-Application
of	O
biological	O
macromolecules	O
,	O
such	O
as	O
proteins	O
and	O
nucleic	O
acids	O
,	O
usually	O
within	O
the	O
framework	O
of	O
molecular	O
dynamics	O
.	O
</s>
<s>
The	O
model	O
can	O
be	O
combined	O
with	O
quantum	O
chemical	O
calculations	O
to	O
formally	O
derive	O
a	O
continuum	O
model	O
of	O
solvent	O
effects	O
suitable	O
for	O
computer	B-Application
simulations	I-Application
of	O
small	O
and	O
large	O
molecular	O
systems	O
.	O
</s>
