<s>
The	O
Re-Mission	B-Application
games	O
for	O
young	O
cancer	O
patients	O
were	O
conceived	O
by	O
Pam	O
Omidyar	O
and	O
designed	O
based	O
research	O
by	O
the	O
nonprofit	O
HopeLab	O
Foundation	O
,	O
with	O
direct	O
input	O
from	O
young	O
cancer	O
patients	O
and	O
oncology	O
doctors	O
and	O
nurses	O
,	O
and	O
game	O
developer	O
Realtime	O
Associates	O
,	O
among	O
others	O
.	O
</s>
<s>
HopeLab	O
has	O
made	O
Re-Mission	B-Application
games	O
available	O
at	O
no	O
charge	O
to	O
young	O
people	O
with	O
cancer	O
and	O
their	O
families	O
,	O
as	O
well	O
as	O
oncology	O
healthcare	O
workers	O
and	O
institutions	O
around	O
the	O
world	O
.	O
</s>
<s>
The	O
original	O
Re-Mission	B-Application
game	O
was	O
released	O
in	O
2006	O
as	O
a	O
Microsoft	B-Application
Windows	I-Application
based	O
third-person	O
shooter	O
based	O
in	O
the	O
serious	B-Application
games	I-Application
genre	O
.	O
</s>
<s>
In	O
Re-Mission	B-Application
,	O
the	O
player	O
controls	O
an	O
RX5-E	O
(	O
"	O
Roxxi	O
"	O
)	O
nanobot	O
who	O
is	O
designed	O
to	O
be	O
injected	O
into	O
the	O
human	O
body	O
and	O
fight	O
particular	O
types	O
of	O
cancer	O
and	O
related	O
infections	O
such	O
as	O
non-Hodgkin	O
lymphoma	O
and	O
leukemia	O
,	O
at	O
a	O
cellular	O
level	O
.	O
</s>
<s>
Copies	O
of	O
Re-Mission	B-Application
were	O
distributed	O
at	O
no	O
charge	O
to	O
others	O
,	O
though	O
donations	O
were	O
accepted	O
.	O
</s>
<s>
As	O
of	O
2012	O
,	O
more	O
than	O
200,000	O
copies	O
of	O
Re-Mission	B-Application
had	O
been	O
distributed	O
in	O
81	O
countries	O
,	O
placing	O
it	O
among	O
the	O
most	O
successful	O
serious	B-Application
games	I-Application
to	O
date	O
.	O
</s>
<s>
On	O
May	O
30	O
,	O
2007	O
,	O
Cigna	O
HealthCare	O
announced	O
a	O
partnership	O
with	O
HopeLab	O
in	O
which	O
Cigna	O
distributes	O
copies	O
of	O
Re-Mission	B-Application
to	O
its	O
members	O
at	O
no	O
cost	O
.	O
</s>
<s>
HopeLab	O
has	O
also	O
partnered	O
with	O
Starlight	O
Children	O
's	O
Foundation	O
and	O
the	O
ESA	O
Foundation	O
to	O
distribute	O
Re-Mission	B-Application
.	O
</s>
<s>
Re-Mission	B-Application
2	O
is	O
the	O
2013	O
follow-up	O
to	O
the	O
original	O
game	O
.	O
</s>
<s>
A	O
collection	O
of	O
free	O
online	O
games	O
,	O
Re-Mission	B-Application
2	O
is	O
designed	O
to	O
improve	O
psychological	O
and	O
behavioral	O
outcomes	O
associated	O
with	O
cancer	O
treatment	O
adherence	O
.	O
</s>
<s>
Re-Mission	B-Application
2	O
applies	O
insights	O
from	O
a	O
published	O
in	O
2012	O
by	O
HopeLab	O
and	O
Stanford	O
University	O
researchers	O
,	O
showing	O
that	O
the	O
Re-Mission	B-Application
video	O
game	O
strongly	O
activates	O
brain	O
circuits	O
involved	O
in	O
positive	O
motivation	O
.	O
</s>
<s>
As	O
a	O
result	O
,	O
each	O
Re-Mission	B-Application
2	O
game	O
is	O
designed	O
to	O
boost	O
positive	O
emotion	O
,	O
increase	O
self-efficacy	O
,	O
and	O
shift	O
attitudes	O
toward	O
chemotherapy	O
.	O
</s>
<s>
Each	O
Re-Mission	B-Application
2	O
game	O
puts	O
players	O
inside	O
the	O
body	O
to	O
defeat	O
cancer	O
,	O
using	O
weapons	O
like	O
chemotherapy	O
,	O
antibiotics	O
and	O
the	O
body	O
's	O
immune	O
cells	O
.	O
</s>
<s>
Research	O
on	O
Re-Mission	B-Application
2	O
shows	O
that	O
the	O
new	O
games	O
are	O
as	O
effective	O
as	O
the	O
original	O
Re-Mission	B-Application
game	O
in	O
increasing	O
players’	O
self-efficacy	O
,	O
boosting	O
positive	O
emotions	O
and	O
shifting	O
attitudes	O
about	O
chemotherapy	O
.	O
</s>
<s>
Re-Mission	B-Application
2	O
games	O
are	O
free	O
to	O
play	O
online	O
at	O
,	O
and	O
Re-Mission	B-Application
2	O
:	O
Nanobot	O
’s	O
Revenge	O
is	O
available	O
for	O
download	O
as	O
a	O
and	O
devices	O
.	O
</s>
<s>
HopeLab	O
conducted	O
an	O
international	O
,	O
multicenter	O
randomized	O
controlled	O
trial	O
to	O
gauge	O
the	O
efficacy	O
of	O
Re-Mission	B-Application
as	O
it	O
relates	O
to	O
compliance	O
with	O
prescribed	O
chemotherapy	O
and	O
antibiotic	O
treatments	O
,	O
cancer-related	O
knowledge	O
,	O
and	O
self-efficacy	O
.	O
</s>
<s>
Subjects	O
received	O
either	O
computers	O
pre-loaded	O
with	O
a	O
popular	O
commercial	O
video	O
game	O
(	O
the	O
control	O
group	O
)	O
or	O
computers	O
preloaded	O
with	O
the	O
same	O
control	O
game	O
plus	O
Re-Mission	B-Application
.	O
</s>
<s>
Study	O
results	O
indicated	O
that	O
playing	O
Re-Mission	B-Application
led	O
to	O
more	O
consistent	O
treatment	O
adherence	O
,	O
faster	O
rate	O
of	O
increase	O
in	O
cancer	O
knowledge	O
,	O
and	O
faster	O
rate	O
of	O
increase	O
in	O
self-efficacy	O
in	O
young	O
cancer	O
patients	O
.	O
</s>
<s>
HopeLab	O
conducted	O
additional	O
research	O
to	O
understand	O
the	O
mechanisms	O
of	O
action	O
that	O
make	O
Re-Mission	B-Application
effective	O
.	O
</s>
<s>
Results	O
of	O
an	O
fMRI	B-Algorithm
study	O
of	O
Re-Mission	B-Application
showing	O
the	O
impact	O
of	O
the	O
game	O
on	O
neurological	O
processes	O
were	O
presented	O
in	O
August	O
2008	O
at	O
the	O
10th	O
International	O
Congress	O
of	O
the	O
Society	O
of	O
Behavioral	O
Medicine	O
.	O
</s>
<s>
This	O
research	O
informed	O
HopeLab	O
's	O
development	O
of	O
Re-Mission	B-Application
2	O
.	O
</s>
