<s>
Raman	B-Algorithm
optical	I-Algorithm
activity	I-Algorithm
(	O
ROA	O
)	O
is	O
a	O
vibrational	O
spectroscopic	O
technique	O
that	O
is	O
reliant	O
on	O
the	O
difference	O
in	O
intensity	O
of	O
Raman	B-Architecture
scattered	I-Architecture
right	O
and	O
left	O
circularly	O
polarised	O
light	O
due	O
to	O
molecular	O
chirality	O
.	O
</s>
<s>
More	O
developments	O
,	O
including	O
important	O
contributions	O
to	O
the	O
development	O
of	O
practical	O
Raman	B-Algorithm
optical	I-Algorithm
activity	I-Algorithm
instruments	O
,	O
were	O
made	O
by	O
Werner	O
Hug	O
of	O
the	O
University	O
of	O
Fribourg	O
,	O
and	O
Lutz	O
Hecht	O
with	O
Laurence	O
Barron	O
at	O
the	O
University	O
of	O
Glasgow	O
.	O
</s>
<s>
The	O
basic	O
principle	O
of	O
Raman	B-Algorithm
optical	I-Algorithm
activity	I-Algorithm
is	O
that	O
there	O
is	O
interference	O
between	O
light	O
waves	O
scattered	O
by	O
the	O
polarizability	O
and	O
optical	O
activity	O
tensors	B-Device
of	O
a	O
chiral	O
molecule	O
,	O
which	O
leads	O
to	O
a	O
difference	O
between	O
the	O
intensities	O
of	O
the	O
right	O
-	O
and	O
left-handed	O
circularly	O
polarised	O
scattered	O
beams	O
.	O
</s>
<s>
Due	O
to	O
its	O
sensitivity	O
to	O
chirality	O
,	O
Raman	B-Algorithm
optical	I-Algorithm
activity	I-Algorithm
is	O
a	O
useful	O
probe	O
of	O
biomolecular	O
structure	O
and	O
behaviour	O
in	O
aqueous	O
solution	O
.	O
</s>
<s>
Though	O
the	O
method	O
does	O
not	O
reveal	O
information	O
to	O
the	O
atomic	O
resolution	O
of	O
crystallographic	O
approaches	O
,	O
it	O
is	O
able	O
to	O
examine	O
structure	O
and	O
behaviour	O
in	O
biologically	O
more	O
realistic	O
conditions	O
(	O
compare	O
the	O
dynamic	O
solution	O
structure	O
examined	O
by	O
Raman	B-Algorithm
optical	I-Algorithm
activity	I-Algorithm
to	O
the	O
static	O
crystal	O
structure	O
)	O
.	O
</s>
<s>
Raman	B-Algorithm
optical	I-Algorithm
activity	I-Algorithm
spectroscopy	O
is	O
related	O
to	O
Raman	B-Algorithm
spectroscopy	I-Algorithm
and	O
circular	O
dichroism	O
.	O
</s>
<s>
Recent	O
studies	O
have	O
shown	O
how	O
by	O
using	O
optical	O
vortex	O
light	O
beams	O
,	O
a	O
distinct	O
type	O
of	O
Raman	B-Algorithm
optical	I-Algorithm
activity	I-Algorithm
that	O
is	O
sensitive	O
to	O
the	O
orbital	O
angular	O
momentum	O
of	O
the	O
incident	O
light	O
is	O
manifest	O
.	O
</s>
