<s>
RTI(-4229 )	O
-55	O
,	O
also	O
called	O
RTI-55	B-Language
or	O
iometopane	B-Language
,	O
is	O
a	O
phenyltropane-based	O
psychostimulant	O
used	O
in	O
scientific	O
research	O
and	O
in	O
some	O
medical	O
applications	O
.	O
</s>
<s>
RTI-55	B-Language
is	O
a	O
non-selective	O
dopamine	O
reuptake	O
inhibitor	O
derived	O
from	O
methylecgonidine	O
.	O
</s>
<s>
However	O
,	O
more	O
selective	O
analogs	O
are	O
derived	O
by	O
conversion	O
to	O
"	O
pyrrolidinoamido	O
"	O
RTI-229	B-Library
,	O
for	O
instance	O
.	O
</s>
<s>
Due	O
to	O
the	O
large	O
bulbous	O
nature	O
of	O
the	O
weakly	O
electron	O
withdrawing	O
iodo	O
halogen	O
atom	O
,	O
RTI-55	B-Language
is	O
the	O
most	O
strongly	O
serotonergic	O
of	O
the	O
simple	O
para-substituted	O
troparil	O
based	O
analogs	O
.	O
</s>
<s>
In	O
rodents	O
RTI-55	B-Language
actually	O
caused	O
death	O
at	O
a	O
dosage	O
of	O
100mg/kg	O
,	O
whereas	O
RTI-51	O
and	O
RTI-31	O
did	O
not	O
.	O
</s>
<s>
Another	O
notable	O
observation	O
is	O
the	O
strong	O
propensity	O
of	O
RTI-55	B-Language
to	O
cause	O
locomotor	O
activity	O
enhancements	O
,	O
although	O
in	O
an	O
earlier	O
study	O
,	O
RTI-51	O
was	O
actually	O
even	O
stronger	O
than	O
RTI-55	B-Language
in	O
shifting	O
baseline	O
LMA	O
.	O
</s>
<s>
RTI-55	B-Language
is	O
one	O
of	O
the	O
most	O
potent	O
phenyltropane	O
stimulants	O
commercially	O
available	O
,	O
which	O
limits	O
its	O
use	O
in	O
humans	O
,	O
as	O
it	O
might	O
have	O
significant	O
abuse	O
potential	O
if	O
used	O
outside	O
a	O
strictly	O
controlled	O
medical	O
setting	O
.	O
</s>
<s>
Although	O
RTI-55	B-Language
was	O
n't	O
specifically	O
examined	O
in	O
this	O
study	O
the	O
number	O
of	O
lever	O
responses	O
in	O
a	O
given	O
session	O
was	O
of	O
the	O
order	O
cocaine	O
>	O
WIN35428	O
>	O
RTI-31	O
>	O
RTI-51	O
.	O
</s>
<s>
The	O
radiopharmaceutical	B-Algorithm
forms	O
of	O
RTI-55	B-Language
,	O
in	O
which	O
the	O
iodine	O
atom	O
is	O
radioiodine	O
so	O
that	O
the	O
drug	O
can	O
be	O
used	O
in	O
single-photon	O
emission	O
computed	O
tomography	O
,	O
are	O
called	O
iometopane	B-Language
I	O
123	O
(	O
USAN	O
)	O
or	O
iometopane	B-Language
123I	O
(	O
INN	O
)	O
and	O
iometopane	B-Language
I	O
125	O
(	O
USAN	O
)	O
or	O
iometopane	B-Language
125I	O
(	O
INN	O
)	O
.	O
</s>
<s>
RTI-55	B-Language
is	O
mainly	O
used	O
in	O
scientific	O
research	O
into	O
the	O
dopamine	O
reuptake	O
transporter	O
.	O
</s>
<s>
Various	O
radiolabelled	O
forms	O
of	O
RTI-55	B-Language
(	O
with	O
different	O
radioactive	O
isotopes	O
of	O
iodine	O
used	O
depending	O
on	O
the	O
application	O
)	O
are	O
used	O
in	O
both	O
humans	O
and	O
animals	O
to	O
map	O
the	O
distribution	O
of	O
dopamine	O
transporters	O
and	O
serotonin	O
transporters	O
in	O
the	O
brain	O
.	O
</s>
<s>
The	O
123I	O
derivative	O
is	O
known	O
as	O
iometopane	B-Language
.	O
</s>
<s>
RTI-55	B-Language
is	O
made	O
as	O
follows	O
:	O
</s>
