<s>
RTI-229	B-Library
,	O
also	O
known	O
as	O
(	O
–	O
)	O
-3β-(4-iodophenyl )	O
tropane-2β-pyrrolidine	O
carboxamide	O
and	O
RTI-4229-229	O
,	O
is	O
a	O
potent	O
and	O
long-lasting	O
stimulant	O
drug	O
which	O
was	O
developed	O
in	O
the	O
1990s	O
as	O
part	O
of	O
a	O
large	O
group	O
of	O
related	O
analogues	O
from	O
the	O
phenyltropane	O
family	O
.	O
</s>
<s>
With	O
the	O
combination	O
of	O
two	O
potent	O
dopamine	O
transporter	O
(	O
DAT	O
)	O
binding	O
motifs	O
attached	O
to	O
the	O
tropane	O
ring	O
,	O
the	O
p-iodophenyl	O
group	O
at	O
the	O
3β-position	O
and	O
a	O
pyrrolidine	O
carboxamide	O
at	O
2β	O
,	O
RTI-229	B-Library
has	O
extremely	O
high	O
selectivity	O
for	O
the	O
dopamine	O
transporter	O
(	O
2600x	O
and	O
4600x	O
selective	O
over	O
NET	O
and	O
5-HTT	O
respectively	O
)	O
and	O
is	O
one	O
of	O
the	O
most	O
DAT-selective	O
compounds	O
in	O
the	O
RTI	O
series	O
.	O
</s>
<s>
RTI-229	B-Library
is	O
mainly	O
used	O
in	O
scientific	O
research	O
into	O
the	O
dopamine	O
reuptake	O
transporter	O
,	O
with	O
its	O
extremely	O
high	O
DAT	O
selectivity	O
making	O
it	O
useful	O
for	O
distinguishing	O
between	O
DAT	O
and	O
NET	O
binding	O
sites	O
in	O
the	O
brain	O
to	O
an	O
even	O
greater	O
extent	O
than	O
related	O
compounds	O
such	O
as	O
RTI-121	B-Algorithm
.	O
</s>
<s>
RTI-229	B-Library
is	O
legal	O
throughout	O
the	O
world	O
as	O
of	O
2010	O
.	O
</s>
<s>
Some	O
jurisdictions	O
such	O
as	O
the	O
United	O
States	O
,	O
Australia	O
and	O
New	O
Zealand	O
might	O
however	O
consider	O
RTI-229	B-Library
to	O
be	O
a	O
controlled	O
substance	O
analogue	O
of	O
cocaine	B-Application
on	O
the	O
grounds	O
of	O
its	O
related	O
chemical	O
structure	O
.	O
</s>
