<s>
PyMOL	B-Application
is	O
an	O
open	B-License
source	I-License
but	O
proprietary	B-Application
molecular	O
visualization	O
system	O
created	O
by	O
Warren	O
Lyford	O
DeLano	O
.	O
</s>
<s>
It	O
was	O
commercialized	O
initially	O
by	O
DeLano	B-Application
Scientific	I-Application
LLC	I-Application
,	O
which	O
was	O
a	O
private	O
software	O
company	O
dedicated	O
to	O
creating	O
useful	O
tools	O
that	O
become	O
universally	O
accessible	O
to	O
scientific	O
and	O
educational	O
communities	O
.	O
</s>
<s>
It	O
is	O
currently	O
commercialized	O
by	O
Schrödinger	O
,	O
Inc	O
.	O
As	O
the	O
original	O
software	B-License
license	I-License
was	O
a	O
permissive	B-License
licence	I-License
,	O
they	O
were	O
able	O
to	O
remove	O
it	O
;	O
new	O
versions	O
are	O
no	O
longer	O
released	O
under	O
the	O
Python	B-License
license	I-License
,	O
but	O
under	O
a	O
custom	O
license	O
(	O
granting	O
broad	O
use	O
,	O
redistribution	O
,	O
and	O
modification	O
rights	O
,	O
but	O
assigning	O
copyright	O
to	O
any	O
version	O
to	O
Schrodinger	O
,	O
LLC	O
.	O
</s>
<s>
PyMOL	B-Application
can	O
produce	O
high-quality	O
3D	O
images	O
of	O
small	O
molecules	O
and	O
biological	O
macromolecules	O
,	O
such	O
as	O
proteins	O
.	O
</s>
<s>
According	O
to	O
the	O
original	O
author	O
,	O
by	O
2009	O
,	O
almost	O
a	O
quarter	O
of	O
all	O
published	O
images	O
of	O
3D	O
protein	O
structures	O
in	O
the	O
scientific	O
literature	O
were	O
made	O
using	O
PyMOL	B-Application
.	O
</s>
<s>
PyMOL	B-Application
is	O
one	O
of	O
the	O
few	O
mostly	O
open-source	B-License
model	I-License
visualization	O
tools	O
available	O
for	O
use	O
in	O
structural	O
biology	O
.	O
</s>
<s>
The	O
Py	O
part	O
of	O
the	O
software	O
's	O
name	O
refers	O
to	O
the	O
program	O
having	O
been	O
written	O
in	O
the	O
programming	O
language	O
Python	B-Language
.	O
</s>
<s>
PyMOL	B-Application
uses	O
OpenGL	O
Extension	O
Wrangler	O
Library	O
(	O
GLEW	O
)	O
and	O
FreeGLUT	B-Application
,	O
and	O
can	O
solve	O
Poisson	B-Algorithm
–	I-Algorithm
Boltzmann	I-Algorithm
equations	I-Algorithm
using	O
the	O
Adaptive	O
Poisson	O
Boltzmann	O
Solver	O
.	O
</s>
<s>
PyMOL	B-Application
used	O
Tk	B-Application
for	O
the	O
GUI	O
widgets	O
and	O
had	O
native	O
Aqua	B-Application
binaries	O
for	O
macOS	B-Application
through	O
Schrödinger	O
,	O
which	O
were	O
replaced	O
with	O
a	O
PyQt	B-Language
user	O
interface	O
on	O
all	O
platforms	O
with	O
the	O
release	O
of	O
version	O
2.0	O
.	O
</s>
<s>
Early	O
versions	O
of	O
PyMol	B-Application
were	O
released	O
under	O
the	O
Python	B-License
License	I-License
.	O
</s>
<s>
On	O
1	O
August	O
2006	O
,	O
DeLano	O
Scientific	O
adopted	O
a	O
controlled-access	O
download	O
system	O
for	O
precompiled	O
PyMOL	B-Application
builds	O
(	O
including	O
betas	O
)	O
distributed	O
by	O
the	O
company	O
.	O
</s>
<s>
Access	O
to	O
these	O
executables	B-Application
is	O
now	O
limited	O
to	O
registered	O
users	O
who	O
are	O
paying	O
customers	O
;	O
educational	O
builds	O
are	O
available	O
free	O
to	O
students	O
and	O
teachers	O
.	O
</s>
<s>
While	O
the	O
build	O
systems	O
for	O
other	O
platforms	O
are	O
open	O
,	O
the	O
Windows	B-Library
API	I-Library
(	O
WinAPI	B-Library
,	O
Win32	B-Library
)	O
build	O
system	O
is	O
not	O
,	O
although	O
unofficial	O
Windows	B-Application
binaries	O
are	O
available	O
online	O
.	O
</s>
<s>
Anyone	O
can	O
either	O
compile	B-Language
an	O
executable	B-Application
from	O
the	O
Python-licensed	O
source	O
code	O
or	O
pay	O
for	O
a	O
subscription	O
to	O
support	O
services	O
to	O
obtain	O
access	O
to	O
precompiled	O
executables	B-Application
.	O
</s>
<s>
On	O
8	O
January	O
2010	O
,	O
Schrödinger	O
,	O
Inc	O
.	O
reached	O
an	O
agreement	O
to	O
acquire	O
PyMOL	B-Application
.	O
</s>
<s>
The	O
firm	O
assumed	O
development	O
,	O
maintenance	O
,	O
support	O
,	O
and	O
sales	O
of	O
PyMOL	B-Application
,	O
including	O
all	O
then-valid	O
subscriptions	O
.	O
</s>
<s>
They	O
also	O
continue	O
to	O
actively	O
support	O
the	O
PyMOL	B-Application
open-source	B-License
community	O
.	O
</s>
<s>
In	O
2017	O
,	O
Schrödinger	O
revamped	O
the	O
distribution	O
system	O
to	O
unify	O
the	O
user	O
interface	O
under	O
Qt	B-Language
and	O
the	O
package	O
management	O
under	O
Anaconda	B-Application
,	O
and	O
released	O
it	O
as	O
PyMol	B-Application
v2	O
.	O
</s>
<s>
The	O
source	O
code	O
remains	O
mostly	O
available	O
,	O
this	O
time	O
under	O
a	O
BSD-like	B-License
license	I-License
.	O
</s>
<s>
As	O
with	O
the	O
previous	O
distribution	O
,	O
unofficial	O
Windows	B-Application
binaries	O
in	O
the	O
wheel	B-Application
format	I-Application
are	O
available	O
,	O
and	O
indeed	O
Linux	B-Application
distributions	I-Application
continue	O
to	O
provide	O
their	O
own	O
builds	O
of	O
the	O
open-source	B-License
code	O
.	O
</s>
<s>
PyMOL	B-Application
applies	O
ball-coloring	O
by	O
element	O
.	O
</s>
