<s>
PLUMED	B-Language
is	O
an	O
open-source	O
library	O
implementing	O
enhanced-sampling	O
algorithms	O
,	O
various	O
free-energy	O
methods	O
,	O
and	O
analysis	O
tools	O
for	O
molecular	O
dynamics	O
simulations	O
.	O
</s>
<s>
It	O
is	O
designed	O
to	O
be	O
used	O
together	O
with	O
ACEMD	O
,	O
AMBER	B-Device
,	O
DL_POLY	O
,	O
GROMACS	B-Application
,	O
LAMMPS	B-Application
,	O
NAMD	B-Application
,	O
OpenMM	B-Application
,	O
ABIN	O
,	O
CP2K	B-Application
,	O
i-PI	O
,	O
PINY-MD	O
,	O
and	O
Quantum	B-Application
ESPRESSO	I-Application
,	O
but	O
it	O
can	O
also	O
be	O
used	O
to	O
together	O
with	O
analysis	O
and	O
visualization	B-Application
tools	O
VMD	B-Application
,	O
HTMD	O
,	O
and	O
OpenPathSampling	O
.	O
</s>
<s>
In	O
addition	O
,	O
PLUMED	B-Language
can	O
be	O
used	O
as	O
a	O
standalone	O
tool	O
for	O
analysis	O
of	O
molecular	O
dynamics	O
trajectories	B-Application
.	O
</s>
<s>
A	O
graphical	B-Application
user	I-Application
interface	I-Application
named	O
METAGUI	O
is	O
available	O
.	O
</s>
<s>
PLUMED	B-Language
offers	O
a	O
large	O
collection	O
of	O
collective	O
variables	O
that	O
serve	O
as	O
descriptions	O
of	O
complex	O
processes	O
that	O
occur	O
during	O
molecular	O
dynamics	O
simulations	O
,	O
for	O
example	O
angles	O
,	O
positions	O
,	O
distances	O
,	O
interaction	O
energies	O
,	O
and	O
total	O
energy	O
.	O
</s>
