<s>
Orthogonal	B-Algorithm
Signal	I-Algorithm
Correction	I-Algorithm
(	O
OSC	O
)	O
is	O
a	O
spectral	O
preprocessing	O
technique	O
that	O
removes	O
variation	O
from	O
a	O
data	O
matrix	O
X	O
that	O
is	O
orthogonal	B-Application
to	O
the	O
response	O
matrix	O
Y	O
.	O
OSC	O
was	O
introduced	O
by	O
researchers	O
at	O
the	O
University	O
of	O
Umea	O
in	O
1998	O
and	O
has	O
since	O
found	O
applications	O
in	O
domains	O
including	O
metabolomics	O
.	O
</s>
