<s>
Optical	B-Algorithm
coherence	I-Algorithm
elastography	I-Algorithm
(	O
OCE	O
)	O
is	O
an	O
emerging	O
imaging	O
technique	O
used	O
in	O
biomedical	B-Application
imaging	I-Application
to	O
form	O
pictures	O
of	O
biological	O
tissue	O
in	O
micron	O
and	O
submicron	O
level	O
and	O
maps	O
the	O
biomechanical	O
property	O
of	O
tissue	O
.	O
</s>
<s>
Elastography	B-Algorithm
was	O
first	O
used	O
in	O
1979	O
and	O
subsequent	O
progress	O
in	O
the	O
field	O
has	O
been	O
extensive	O
,	O
based	O
largely	O
on	O
ultrasound	O
,	O
and	O
magnetic	O
resonance	O
imaging	O
.	O
</s>
<s>
Optical	O
techniques	O
have	O
also	O
been	O
proposed	O
for	O
elastography	B-Algorithm
to	O
probe	O
mechanical	O
properties	O
of	O
tissues	O
dates	O
back	O
to	O
at	O
least	O
the	O
1950s	O
.	O
</s>
<s>
In	O
1998	O
,	O
Schmitt	O
first	O
proposed	O
optical	B-Algorithm
coherence	I-Algorithm
elastography	I-Algorithm
(	O
OCE	O
)	O
,	O
in	O
employing	O
optical	B-Application
coherence	I-Application
tomography	I-Application
(	O
OCT	O
)	O
detect	O
depth-resolved	O
sample	O
deformation	O
induced	O
by	O
quasi-static	O
compression	O
.	O
</s>
<s>
But	O
the	O
term	O
optical	B-Algorithm
coherence	I-Algorithm
elastography	I-Algorithm
was	O
first	O
coined	O
in	O
a	O
2004	O
paper	O
with	O
Brett	O
Bouma	O
.	O
</s>
<s>
Requiring	O
no	O
injections	O
,	O
OCE	O
is	O
a	O
non-invasive	O
imaging	O
method	O
can	O
gives	O
more	O
details	O
than	O
ultrasound	O
or	O
MRI	B-Algorithm
.	O
</s>
<s>
And	O
it	O
is	O
also	O
more	O
affordable	O
and	O
time	O
efficient	O
compared	O
to	O
MRI	B-Algorithm
.	O
</s>
<s>
But	O
the	O
term	O
optical	B-Algorithm
coherence	I-Algorithm
elastography	I-Algorithm
was	O
first	O
coined	O
in	O
a	O
2004	O
paper	O
with	O
Brett	O
Bouma	O
.	O
</s>
<s>
Although	O
optical	B-Application
coherence	I-Application
tomography	I-Application
(	O
OCT	O
)	O
provide	O
crucial	O
information	O
for	O
the	O
diagnosis	O
,	O
they	O
often	O
are	O
insufficient	O
for	O
early	O
diagnosis	O
,	O
before	O
structural	O
changes	O
occur	O
.	O
</s>
<s>
Elastography	B-Algorithm
,	O
the	O
display	O
of	O
the	O
elastic	O
properties	O
of	O
soft	O
tissues	O
,	O
may	O
be	O
performed	O
using	O
ultrasound	O
,	O
magnetic	O
resonance	O
imaging	O
(	O
MRI	B-Algorithm
)	O
or	O
OCT	O
.	O
Elastography	B-Algorithm
has	O
been	O
proven	O
feasible	O
for	O
characterization	O
of	O
ocular	O
tissues	O
.	O
</s>
<s>
The	O
assumption	O
of	O
linearity	O
is	O
commonly	O
valid	O
for	O
the	O
level	O
of	O
strain	O
(	O
typically	O
<	O
10%	O
)	O
applied	O
in	O
elastography	B-Algorithm
.	O
</s>
<s>
Optical	B-Algorithm
coherence	I-Algorithm
elastography	I-Algorithm
holds	O
great	O
promise	O
for	O
detecting	O
and	O
monitoring	O
the	O
altered	O
mechanical	O
properties	O
that	O
accompany	O
many	O
clinical	O
conditions	O
and	O
pathologies	O
,	O
particularly	O
in	O
cancer	O
,	O
cardiovascular	O
disease	O
and	O
eye	O
disease	O
.	O
</s>
<s>
This	O
task	O
has	O
always	O
been	O
done	O
by	O
utilizing	O
intravascular	O
ultrasound	O
(	O
IVUS	O
)	O
elastography	B-Algorithm
to	O
characterize	O
the	O
elastic	O
properties	O
of	O
parts	O
within	O
the	O
plaque	O
.	O
</s>
<s>
However	O
,	O
detailed	O
plaque	O
structural	O
detection	O
could	O
be	O
limited	O
due	O
to	O
IVUS	O
elastography	B-Algorithm
's	O
relatively	O
low	O
spatial	O
frequency	O
(	O
hundreds	O
of	O
microns	O
)	O
.	O
</s>
<s>
Intravascular	O
OCE	O
could	O
perfectly	O
complements	O
IVUS	O
elastography	B-Algorithm
by	O
developing	O
high-resolution	O
biomechanical	O
imaging	O
of	O
the	O
arterial	O
wall	O
.	O
</s>
