<s>
OpenWorm	B-Application
is	O
an	O
international	O
open	O
science	O
project	O
for	O
the	O
purpose	O
of	O
simulating	O
the	O
roundworm	O
Caenorhabditis	O
elegans	O
at	O
the	O
cellular	O
level	O
.	O
</s>
<s>
This	O
bottom	O
up	O
simulation	O
is	O
being	O
pursued	O
by	O
the	O
OpenWorm	B-Application
community	O
.	O
</s>
<s>
As	O
of	O
2014	O
,	O
a	O
physics	O
engine	O
called	O
Sibernetic	B-Language
has	O
been	O
built	O
for	O
the	O
project	O
and	O
models	O
of	O
the	O
neural	O
connectome	O
and	O
a	O
muscle	O
cell	O
have	O
been	O
created	O
in	O
NeuroML	O
format	O
.	O
</s>
<s>
A	O
3D	O
model	O
of	O
the	O
worm	O
anatomy	O
can	O
be	O
accessed	O
through	O
the	O
web	O
via	O
the	O
OpenWorm	B-Application
browser	O
.	O
</s>
<s>
The	O
OpenWorm	B-Application
project	O
is	O
also	O
contributing	O
to	O
develop	O
Geppetto	O
,	O
a	O
web-based	O
multi-algorithm	O
,	O
multi-scale	O
simulation	O
platform	O
engineered	O
to	O
support	O
the	O
simulation	O
of	O
the	O
whole	O
organism	O
.	O
</s>
<s>
Although	O
the	O
ultimate	O
goal	O
is	O
to	O
simulate	O
all	O
features	O
of	O
C	O
.	O
elegans'''	O
behaviour	O
,	O
the	O
project	O
is	O
new	O
and	O
the	O
first	O
behaviour	O
the	O
OpenWorm	B-Application
community	O
decided	O
to	O
simulate	O
is	O
a	O
simple	O
motor	O
response	O
:	O
teaching	O
the	O
worm	O
to	O
crawl	O
.	O
</s>
<s>
The	O
neural	O
properties	O
are	O
being	O
modeled	O
by	O
a	O
Hodgkin-Huxley	O
model	O
,	O
and	O
the	O
mechanical	O
properties	O
are	O
being	O
modeled	O
by	O
a	O
Smoothed	B-Application
Particle	I-Application
Hydrodynamics	I-Application
algorithm	O
.	O
</s>
<s>
The	O
OpenWorm	B-Application
team	O
built	O
an	O
engine	O
called	O
Geppetto	O
which	O
could	O
integrate	O
these	O
algorithms	O
and	O
due	O
to	O
its	O
modularity	O
will	O
be	O
able	O
to	O
model	O
other	O
biological	O
systems	O
(	O
like	O
digestion	O
)	O
which	O
the	O
team	O
will	O
tackle	O
at	O
a	O
later	O
time	O
.	O
</s>
<s>
Although	O
we	O
have	O
the	O
complete	O
structural	O
connectome	O
,	O
we	O
do	O
not	O
know	O
the	O
synaptic	B-Algorithm
weights	I-Algorithm
at	O
each	O
of	O
the	O
known	O
synapses	O
.	O
</s>
<s>
The	O
OpenWorm	B-Application
community	O
is	O
committed	O
to	O
the	O
ideals	O
of	O
open	O
science	O
.	O
</s>
<s>
All	O
the	O
software	O
that	O
OpenWorm	B-Application
has	O
produced	O
is	O
completely	O
free	O
and	O
open	O
source	O
.	O
</s>
<s>
OpenWorm	B-Application
is	O
also	O
trying	O
a	O
radically	O
open	O
model	O
of	O
scientific	O
collaboration	O
.	O
</s>
