<s>
OpenMM	B-Application
is	O
a	O
library	O
for	O
performing	O
molecular	O
dynamics	O
simulations	O
on	O
a	O
wide	O
variety	O
of	O
hardware	O
architectures	O
.	O
</s>
<s>
It	O
is	O
notable	O
for	O
its	O
implementation	O
in	O
the	O
Folding	B-Application
@home	I-Application
project	O
's	O
core22	O
kernel	O
.	O
</s>
<s>
Core22	O
,	O
also	O
developed	O
at	O
the	O
Pande	O
lab	O
,	O
uses	O
OpenMM	B-Application
to	O
perform	O
protein	O
dynamics	O
simulations	O
on	O
GPUs	B-Architecture
via	O
CUDA	B-Architecture
and	O
OpenCL	B-Application
.	O
</s>
<s>
During	O
the	O
COVID-19	O
pandemic	O
,	O
a	O
peak	O
of	O
280,000	O
GPUs	B-Architecture
were	O
estimated	O
to	O
be	O
running	O
OpenMM	B-Application
via	O
core22	O
.	O
</s>
<s>
OpenMM	B-Application
has	O
a	O
C++	B-Language
API	O
as	O
well	O
as	O
a	O
Python	B-Language
wrapper	B-Library
.	O
</s>
<s>
Developers	O
are	O
able	O
to	O
customize	O
force	O
fields	O
as	O
well	O
as	O
integrators	B-Algorithm
for	O
low-level	O
simulation	O
control	O
.	O
</s>
<s>
Users	O
who	O
only	O
require	O
high-level	O
control	O
of	O
their	O
simulations	O
can	O
use	O
built-in	O
force	O
fields	O
(	O
consisting	O
of	O
many	O
commonly	O
used	O
force	O
fields	O
)	O
and	O
built	O
in	O
integrators	B-Algorithm
like	O
Langevin	O
,	O
Verlet	B-Language
,	O
Nosé	B-Algorithm
–	I-Algorithm
Hoover	I-Algorithm
,	O
and	O
Brownian	O
.	O
</s>
