<s>
Furthermore	O
,	O
estimation	O
in	O
limited	O
or	O
full	O
Bayesian	O
frameworks	O
is	O
performed	O
using	O
the	O
Metropolis-Hastings	B-Algorithm
or	O
the	O
NUTS	O
algorithms	O
.	O
</s>
<s>
SAS	B-Language
is	O
a	O
package	O
that	O
is	O
used	O
in	O
the	O
wide	O
statistical	O
community	O
and	O
supports	O
multiple	O
estimation	O
methods	O
from	O
PROC	O
NLMIX	O
.	O
</s>
<s>
Multiple	O
estimation	O
methods	O
are	O
available	O
in	O
the	O
R	B-Language
open	O
source	O
software	O
system	O
,	O
such	O
as	O
nlme	O
.	O
</s>
<s>
MATLAB	B-Language
provides	O
multiple	O
estimation	O
methods	O
in	O
their	O
nlmefit	O
system	O
.	O
</s>
<s>
SPSS	B-Algorithm
at	O
the	O
moment	O
does	O
not	O
support	O
non-linear	O
mixed	O
effects	O
methods	O
.	O
</s>
<s>
WinBUGS	B-Algorithm
is	O
an	O
implementation	O
of	O
the	O
Metropolis-Hastings	B-Algorithm
method	O
for	O
Bayesian	O
analysis	O
.	O
</s>
<s>
Stan	B-Application
is	O
open	O
source	O
software	O
that	O
implements	O
the	O
NUTS	O
algorithm	O
.	O
</s>
<s>
Pumas	O
implements	O
multiple	O
estimation	O
methods	O
in	O
the	O
julia	B-Application
language	I-Application
.	O
</s>
<s>
nlmixr/nlmixr2	O
is	O
a	O
suite	O
interfaced	O
in	O
R	B-Language
that	O
implements	O
FOCE	O
and	O
SAEM	O
.	O
</s>
<s>
Popular	O
solvers	O
are	O
Runge-Kutta	B-Algorithm
based	O
methods	O
,	O
various	O
stiff	O
solvers	O
and	O
switching	O
solvers	O
such	O
as	O
LSODA	O
of	O
the	O
LAPACK	B-Application
suite	O
.	O
</s>
