<s>
It	O
is	O
most	O
commonly	O
used	O
by	O
biostatisticians	O
to	O
calculate	O
sample	O
size	O
and	O
statistical	B-General_Concept
power	I-General_Concept
for	O
adaptive	O
clinical	O
trial	O
design	O
.	O
</s>
<s>
nQuery	O
is	O
proprietary	B-Application
software	I-Application
developed	O
and	O
distributed	O
by	O
Statsols	O
.	O
</s>
<s>
While	O
at	O
UCLA	O
and	O
Cedars-Sinai	O
during	O
the	O
1990s	O
,	O
she	O
wrote	O
the	O
program	O
nQuery	B-Algorithm
Sample	I-Algorithm
Size	I-Algorithm
Software	I-Algorithm
(	O
then	O
named	O
nQuery	O
Advisor	O
)	O
.	O
</s>
<s>
nQuery	O
allows	O
researchers	O
to	O
apply	O
both	O
frequentist	B-General_Concept
and	O
Bayesian	O
statistics	O
to	O
calculate	O
the	O
appropriate	O
sample	O
size	O
for	O
their	O
study	O
.	O
</s>
