<s>
Molecular	B-Application
Evolutionary	I-Application
Genetics	I-Application
Analysis	I-Application
(	O
MEGA	O
)	O
is	O
computer	O
software	O
for	O
conducting	O
statistical	O
analysis	O
of	O
molecular	O
evolution	O
and	O
for	O
constructing	O
phylogenetic	O
trees	O
.	O
</s>
<s>
It	O
is	O
licensed	B-License
as	O
proprietary	B-License
freeware	I-License
.	O
</s>
<s>
The	O
personal	B-Device
computers	I-Device
then	O
lacked	O
the	O
ability	O
to	O
send	O
the	O
monograph	O
and	O
software	O
electronically	O
,	O
so	O
they	O
were	O
delivered	O
by	O
postal	O
mail	O
.	O
</s>
<s>
The	O
monograph	O
Molecular	B-Application
Evolutionary	I-Application
Genetics	I-Application
Analysis	I-Application
was	O
often	O
used	O
as	O
a	O
textbook	O
for	O
new	O
ways	O
to	O
study	O
molecular	O
evolution	O
.	O
</s>
<s>
The	O
latest	O
release	O
,	O
MEGA7	O
,	O
has	O
been	O
optimized	O
for	O
use	O
on	O
64-bit	B-Device
computing	I-Device
systems	O
.	O
</s>
<s>
A	O
graphical	O
user	O
interface	O
is	O
available	O
as	O
a	O
native	O
Microsoft	B-Application
Windows	I-Application
program	O
.	O
</s>
<s>
+	O
Major	O
MEGA	O
versions	O
Version	O
Release	O
date1.019931.11994Kumar	O
,	O
S.	O
,	O
K	O
.	O
Tamura	O
,	O
and	O
M	O
.	O
Nei	O
(	O
1994	O
)	O
MEGA	O
:	O
Molecular	B-Application
Evolutionary	I-Application
Genetics	I-Application
Analysis	I-Application
software	O
for	O
microcomputers	O
.	O
</s>
<s>
CABIOS	O
10:189-191.2.020002.120013.02004Kumar	O
,	O
S.	O
,	O
Tamura	O
,	O
K.	O
,	O
and	O
Nei	O
,	O
M	O
.	O
(	O
2004	O
)	O
MEGA3	O
:	O
Molecular	B-Application
Evolutionary	I-Application
Genetics	I-Application
Analysis	I-Application
.	O
</s>
<s>
Bioinformatics	O
5:150-163.4.02006Tamura	O
,	O
K.	O
,	O
Dudley	O
,	O
J.	O
,	O
Nei	O
,	O
M.	O
,	O
Kumar	O
,	O
S	O
.	O
(	O
2007	O
)	O
MEGA4	O
:	O
Molecular	B-Application
Evolutionary	I-Application
Genetics	I-Application
Analysis	I-Application
.	O
</s>
<s>
24(8 )	O
:1596-1599.4.120085.02011Tamura	O
,	O
K.	O
,	O
Peterson	O
,	O
D.	O
,	O
Peterson	O
,	O
N.	O
,	O
Stecher	O
,	O
G.	O
,	O
Nei	O
,	O
M.	O
,	O
Kumar	O
,	O
S	O
.	O
(	O
2011	O
)	O
MEGA5	O
:	O
Molecular	B-Application
Evolutionary	I-Application
Genetics	I-Application
Analysis	I-Application
using	O
Maximum	O
Likelihood	O
,	O
Evolutionary	O
Distance	O
,	O
and	O
Maximum	O
Parsimony	O
Methods	O
.	O
</s>
<s>
MEGA7	O
:	O
Molecular	B-Application
Evolutionary	I-Application
Genetics	I-Application
Analysis	I-Application
version	O
7.0	O
for	O
bigger	O
datasets	O
.	O
</s>
<s>
MEGA	O
X	O
:	O
Molecular	B-Application
Evolutionary	I-Application
Genetics	I-Application
Analysis	I-Application
across	O
computing	O
platforms	O
.	O
</s>
<s>
MEGA	O
offers	O
several	O
approaches	O
for	O
testing	O
substitution	O
pattern	O
homogeneity	O
,	O
such	O
as	O
composition	O
distance	O
,	O
disparity	O
index	O
,	O
and	O
Monte	B-Algorithm
Carlo	I-Algorithm
tests	O
.	O
</s>
<s>
The	O
Monte	B-Algorithm
Carlo	I-Algorithm
test	O
is	O
another	O
approach	O
to	O
test	O
substitution	O
pattern	O
homogeneity	O
that	O
involves	O
running	O
a	O
null	O
distribution	O
simulation	O
.	O
</s>
<s>
These	O
tests	O
are	O
commonly	O
used	O
for	O
analytical	O
formulas	O
or	O
bootstrapping	B-Application
resampling	O
in	O
MEGA	O
.	O
</s>
<s>
Each	O
method	O
allows	O
for	O
a	O
bootstrap	B-Application
phylogeny	O
test	O
with	O
any	O
number	O
of	O
replications	O
.	O
</s>
<s>
Neighbor	B-Algorithm
joining	I-Algorithm
and	O
minimum	O
evolution	O
allows	O
for	O
an	O
interior-branch	O
test	O
instead	O
.	O
</s>
<s>
The	O
compute	O
menu	O
provides	O
options	O
for	O
computing	O
a	O
condensed	O
tree	O
,	O
a	O
consensus	O
tree	O
,	O
or	O
a	O
timetree	B-Application
with	O
or	O
without	O
a	O
molecular	O
clock	O
.	O
</s>
<s>
The	O
tree	O
topology	O
can	O
be	O
exported	O
to	O
a	O
file	O
in	O
MEGA	O
tree	O
format	O
,	O
or	O
for	O
timetrees	B-Application
,	O
exported	O
in	O
a	O
tabular	O
format	O
with	O
relevant	O
information	O
used	O
when	O
constructing	O
the	O
timetree	B-Application
.	O
</s>
<s>
Other	O
export	O
options	O
include	O
the	O
current	O
timetree	B-Application
calibrations	O
,	O
analysis	O
summary	O
,	O
partition	O
list	O
,	O
and	O
pairwise	O
distances	O
.	O
</s>
