<s>
Metascape	B-Application
is	O
a	O
free	O
gene	O
annotation	O
and	O
analysis	O
resource	O
that	O
helps	O
biologists	O
make	O
sense	O
of	O
one	O
or	O
multiple	O
gene	O
lists	O
.	O
</s>
<s>
Metascape	B-Application
provides	O
automated	O
meta-analysis	O
tools	O
to	O
understand	O
either	O
common	O
or	O
unique	O
pathways	O
and	O
protein	O
networks	O
within	O
a	O
group	O
of	O
orthogonal	O
target-discovery	O
studies	O
.	O
</s>
<s>
Although	O
a	O
number	O
of	O
bioinformatics	O
sources	O
exist	O
for	O
this	O
purpose	O
,	O
such	O
as	O
DAVID	B-Application
,	O
they	O
are	O
not	O
all	O
free	O
,	O
easy	O
to	O
use	O
,	O
and	O
well	O
maintained	O
.	O
</s>
<s>
According	O
to	O
the	O
Metascape	B-Application
blog	O
,	O
a	O
team	O
of	O
scientists	O
self-organized	O
to	O
address	O
this	O
challenge	O
.	O
</s>
<s>
Metascape	B-Application
was	O
first	O
released	O
as	O
a	O
beta	O
version	O
on	O
Oct	O
8	O
,	O
2015	O
.	O
</s>
<s>
The	O
first	O
Metascape	B-Application
application	O
was	O
published	O
on	O
Dec	O
9	O
,	O
2015	O
.	O
</s>
<s>
Metascape	B-Application
has	O
gone	O
through	O
multiple	O
releases	O
since	O
then	O
.	O
</s>
<s>
It	O
currently	O
supports	O
key	O
model	O
organisms	O
,	O
pathway	O
enrichment	O
analysis	O
,	O
protein-protein	O
interaction	O
network	O
and	O
component	O
analysis	O
,	O
automatic	O
presentation	O
of	O
the	O
results	O
as	O
publication-ready	O
web	O
report	O
,	O
Excel	B-Application
and	O
PowerPoint	B-Application
presentations	O
.	O
</s>
<s>
The	O
paper	O
titled	O
"	O
Metascape	B-Application
provides	O
a	O
biologist-oriented	O
resource	O
for	O
the	O
analysis	O
of	O
systems-level	O
datasets	O
"	O
was	O
published	O
on	O
Apr	O
3	O
,	O
2019	O
in	O
Nature	O
Communications	O
.	O
</s>
<s>
Metascape	B-Application
implements	O
a	O
CAME	O
analysis	O
workflow	O
:	O
</s>
<s>
Metascape	B-Application
integrated	O
over	O
40	O
bioinformatics	O
knowledgebase	O
into	O
a	O
seamless	O
user	O
interface	O
,	O
where	O
experimental	O
biologists	O
can	O
use	O
a	O
single-click	O
Express	O
Analysis	O
feature	O
to	O
turn	O
multiple	O
gene	O
lists	O
into	O
interpretable	O
results	O
.	O
</s>
<s>
All	O
analysis	O
results	O
are	O
presented	O
in	O
a	O
web	O
report	O
,	O
which	O
contains	O
Excel	B-Application
annotation	O
and	O
enrichment	O
sheets	O
,	O
PowerPoint	B-Application
slides	O
,	O
and	O
custom	O
analysis	O
files	O
(	O
e.g.	O
,	O
.cys	O
file	O
by	O
Cytoscape	B-Language
,	O
.svg	O
by	O
)	O
for	O
further	O
offline	O
analysis	O
or	O
processing	O
.	O
</s>
<s>
One	O
noticeable	O
strength	O
of	O
Metascape	B-Application
is	O
its	O
visualization	O
capability	O
.	O
</s>
<s>
Metascape	B-Application
has	O
aided	O
in	O
the	O
interpretation	O
of	O
2,600	O
published	O
studies	O
as	O
of	O
December	O
2021	O
,	O
among	O
which	O
2/3	O
of	O
publications	O
made	O
use	O
of	O
graphs	O
or	O
sheets	O
prepared	O
by	O
Metascape	B-Application
.	O
</s>
<s>
Metascape	B-Application
for	O
Bioinformaticians	O
(	O
MSBio	O
)	O
was	O
released	O
in	O
2021	O
to	O
meet	O
the	O
growing	O
needs	O
of	O
computational	O
biologists	O
to	O
automate	O
Metascape	B-Application
batch	O
analyses	O
for	O
large-scale	O
gene	O
lists	O
.	O
</s>
<s>
MSBio	O
databases	O
are	O
updated	O
in	O
synchronization	O
with	O
the	O
Metascape	B-Application
web	O
site	O
.	O
</s>
