<s>
MacroModel	B-Application
is	O
a	O
computer	O
program	O
for	O
molecular	O
modelling	O
of	O
organic	O
compounds	O
and	O
biopolymers	O
.	O
</s>
<s>
MacroModel	B-Application
is	O
maintained	O
by	O
Schrödinger	O
,	O
LLC	O
.	O
</s>
<s>
It	O
performs	O
simulations	O
in	O
the	O
framework	O
of	O
classical	O
mechanics	O
,	O
also	O
termed	O
molecular	O
mechanics	O
,	O
and	O
can	O
perform	O
molecular	O
dynamics	O
simulations	O
to	O
model	O
systems	O
at	O
finite	O
temperatures	O
using	O
stochastic	O
dynamics	O
and	O
mixed	O
Monte	B-Algorithm
Carlo	I-Algorithm
algorithms	O
.	O
</s>
<s>
MacroModel	B-Application
supports	O
Windows	B-Application
,	O
Linux	B-Application
,	O
macOS	B-Application
,	O
Silicon	O
Graphics	O
(	O
SGI	O
)	O
IRIX	B-Operating_System
,	O
and	O
IBM	B-Application
AIX	I-Application
.	O
</s>
<s>
The	O
Macromodel	B-Application
software	O
package	O
was	O
first	O
been	O
described	O
in	O
the	O
scientific	O
literature	O
in	O
1990	O
,	O
and	O
has	O
been	O
subsequently	O
acquired	O
by	O
Schrödinger	O
,	O
Inc	O
.	O
in	O
2000	O
.	O
</s>
