<s>
M	B-Algorithm
current	I-Algorithm
is	O
a	O
type	O
of	O
noninactivating	O
potassium	O
current	O
first	O
discovered	O
in	O
bullfrog	O
sympathetic	O
ganglion	O
cells	O
.	O
</s>
<s>
The	O
M-channel	B-Algorithm
is	O
a	O
voltage-gated	O
K+	O
channel	O
(	O
Kv7/KCNQ	O
family	O
)	O
that	O
is	O
named	O
after	O
the	O
receptor	O
it	O
is	O
influenced	O
by	O
.	O
</s>
<s>
The	O
M-channel	B-Algorithm
is	O
important	O
in	O
raising	O
the	O
threshold	O
for	O
firing	O
an	O
action	B-Algorithm
potential	I-Algorithm
.	O
</s>
<s>
The	O
M-channel	B-Algorithm
is	O
a	O
PIP2-regulated	O
ion	O
channel	O
.	O
</s>
<s>
M-channels	B-Algorithm
are	O
the	O
reason	O
for	O
slow	O
depolarizations	O
produced	O
by	O
ACh	O
and	O
LHRH	O
in	O
the	O
autonomic	O
ganglia	O
and	O
other	O
specified	O
areas	O
.	O
</s>
<s>
Initial	O
depolarization	O
of	O
a	O
neuron	O
increases	O
likelihood	O
that	O
M-channels	B-Algorithm
will	O
open	O
.	O
</s>
<s>
M-channels	B-Algorithm
generate	O
an	O
outward	O
potassium	O
current	O
(	O
IK	O
)	O
.	O
</s>
<s>
Potassium	O
efflux	O
counteracts	O
sodium	O
influx	O
in	O
action	B-Algorithm
potential	I-Algorithm
(	O
AP	O
)	O
.	O
</s>
<s>
Overall	O
result	O
:	O
full	O
action	B-Algorithm
potential	I-Algorithm
is	O
prevented	O
.	O
</s>
<s>
There	O
is	O
some	O
evidence	O
for	O
different	O
theories	O
of	O
how	O
M-channel	B-Algorithm
activity	O
is	O
directly	O
affected	O
by	O
PIP2	O
.	O
</s>
