<s>
MLwiN	B-Algorithm
is	O
a	O
statistical	B-Algorithm
software	I-Algorithm
package	O
for	O
fitting	O
multilevel	B-General_Concept
models	I-General_Concept
.	O
</s>
<s>
It	O
uses	O
both	O
maximum	O
likelihood	O
estimation	O
and	O
Markov	B-General_Concept
chain	I-General_Concept
Monte	I-General_Concept
Carlo	I-General_Concept
(	O
MCMC	O
)	O
methods	O
.	O
</s>
<s>
MLwiN	B-Algorithm
is	O
based	O
on	O
an	O
earlier	O
package	O
,	O
MLn	O
,	O
but	O
with	O
a	O
graphical	B-Application
user	I-Application
interface	I-Application
(	O
as	O
well	O
as	O
other	O
additional	O
features	O
)	O
.	O
</s>
<s>
MLwiN	B-Algorithm
represents	O
multilevel	B-General_Concept
models	I-General_Concept
using	O
mathematical	O
notation	O
including	O
Greek	O
letters	O
and	O
multiple	O
subscripts	O
,	O
so	O
the	O
user	O
needs	O
to	O
be	O
(	O
or	O
become	O
)	O
familiar	O
with	O
such	O
notation	O
.	O
</s>
<s>
For	O
a	O
tutorial	O
introduction	O
to	O
multilevel	B-General_Concept
models	I-General_Concept
and	O
their	O
applications	O
in	O
medical	O
statistics	O
illustrated	O
using	O
MLwiN	B-Algorithm
,	O
see	O
Goldstein	O
et	O
al	O
.	O
</s>
