<s>
The	O
MEME	B-Application
suite	I-Application
is	O
a	O
collection	O
of	O
tools	O
for	O
the	O
discovery	O
and	O
analysis	O
of	O
sequence	O
motifs	O
.	O
</s>
<s>
MAST	O
scores	O
the	O
matches	O
and	O
reports	O
p-values	B-General_Concept
for	O
four	O
types	O
of	O
events	O
:	O
</s>
<s>
Position	O
p-value	B-General_Concept
:	O
The	O
p-value	B-General_Concept
of	O
a	O
match	O
of	O
a	O
given	O
position	O
within	O
a	O
sequence	O
to	O
a	O
motif	O
is	O
defined	O
as	O
the	O
probability	O
of	O
a	O
randomly	O
selected	O
position	O
in	O
a	O
randomly	O
generated	O
sequence	O
having	O
a	O
match	O
score	O
at	O
least	O
as	O
large	O
as	O
that	O
of	O
the	O
given	O
position	O
.	O
</s>
<s>
Note:If	O
MAST	O
is	O
combining	O
reverse	O
complement	O
DNA	O
strands	O
,	O
the	O
position	O
p-value	B-General_Concept
is	O
not	O
corrected	O
for	O
multiple	O
tests	O
.	O
</s>
<s>
Sequence	O
p-value	B-General_Concept
:	O
The	O
p-value	B-General_Concept
of	O
a	O
match	O
of	O
a	O
sequence	O
to	O
a	O
motif	O
is	O
defined	O
as	O
the	O
probability	O
of	O
a	O
randomly	O
generated	O
sequence	O
of	O
the	O
same	O
length	O
having	O
a	O
match	O
score	O
at	O
least	O
as	O
large	O
as	O
the	O
largest	O
match	O
score	O
of	O
any	O
position	O
in	O
the	O
sequence	O
.	O
</s>
<s>
Combined	O
p-value	B-General_Concept
:	O
The	O
p-value	B-General_Concept
of	O
a	O
match	O
of	O
a	O
sequence	O
to	O
a	O
group	O
of	O
motifs	O
is	O
defined	O
as	O
the	O
probability	O
of	O
a	O
randomly	O
generated	O
sequence	O
of	O
the	O
same	O
length	O
having	O
sequence	O
p-values	B-General_Concept
whose	O
product	O
is	O
at	O
least	O
as	O
small	O
as	O
the	O
product	O
of	O
the	O
sequence	O
p-values	B-General_Concept
of	O
the	O
matches	O
of	O
the	O
motifs	O
to	O
the	O
given	O
sequence	O
.	O
</s>
<s>
E-value	B-General_Concept
:	O
The	O
E-value	B-General_Concept
of	O
the	O
match	O
of	O
a	O
sequence	O
in	O
a	O
database	O
to	O
a	O
group	O
of	O
motifs	O
is	O
defined	O
as	O
the	O
expected	O
number	O
of	O
sequences	O
in	O
a	O
random	O
database	O
of	O
the	O
same	O
size	O
that	O
would	O
match	O
the	O
motifs	O
as	O
well	O
as	O
the	O
sequence	O
does	O
and	O
is	O
equal	O
to	O
the	O
combined	O
p-value	B-General_Concept
of	O
the	O
sequence	O
times	O
the	O
number	O
of	O
sequences	O
in	O
the	O
database	O
.	O
</s>
