<s>
Martini	B-Algorithm
is	O
a	O
coarse-grained	O
(	O
CG	O
)	O
force	O
field	O
developed	O
by	O
Marrink	O
and	O
coworkers	O
at	O
the	O
University	O
of	O
Groningen	O
,	O
initially	O
developed	O
in	O
2004	O
for	O
molecular	O
dynamics	O
simulation	O
of	O
lipids	O
,	O
later	O
(	O
2007	O
)	O
extended	O
to	O
various	O
other	O
molecules	O
.	O
</s>
<s>
In	O
2021	O
,	O
a	O
new	O
version	O
of	O
the	O
force	O
field	O
has	O
been	O
published	O
,	O
dubbed	O
Martini	B-Algorithm
3	O
.	O
</s>
<s>
For	O
the	O
Martini	B-Algorithm
force	O
field	O
4	O
bead	O
categories	O
have	O
been	O
defined	O
:	O
Q	O
(	O
charged	O
)	O
,	O
P	O
(	O
polar	O
)	O
,	O
N	O
(	O
nonpolar	O
)	O
,	O
and	O
C	O
(	O
apolar	O
)	O
.	O
</s>
<s>
The	O
Martini	B-Algorithm
force	O
field	O
has	O
become	O
one	O
of	O
the	O
most	O
used	O
coarse	O
grained	O
force	O
fields	O
in	O
the	O
field	O
of	O
molecular	O
dynamics	O
simulations	O
for	O
biomolecules	O
.	O
</s>
<s>
The	O
force	O
field	O
has	O
been	O
implemented	O
in	O
three	O
major	O
simulation	O
codes	O
:	O
GROningen	O
MAchine	O
for	O
Chemical	O
Simulations	O
(	O
GROMACS	B-Application
)	O
,	O
GROningen	O
MOlecular	O
Simulation	O
(	O
GROMOS	B-Application
)	O
,	O
and	O
Nanoscale	O
Molecular	O
Dynamics	O
(	O
NAMD	B-Application
)	O
.	O
</s>
<s>
Martini	B-Algorithm
proteins	O
are	O
often	O
simulated	O
in	O
combination	O
with	O
an	O
elastic	O
network	O
,	O
such	O
as	O
Elnedyn	O
,	O
to	O
maintain	O
the	O
overall	O
structure	O
.	O
</s>
<s>
However	O
,	O
the	O
use	O
of	O
the	O
elastic	O
network	O
restricts	O
the	O
use	O
of	O
the	O
MARTINI	B-Algorithm
force	O
field	O
for	O
the	O
study	O
of	O
large	O
conformational	O
changes	O
(	O
e.g.	O
</s>
<s>
Parameters	O
for	O
different	O
other	O
molecules	O
,	O
including	O
carbon	O
nanoparticles	O
,	O
ionic	O
liquids	O
,	O
and	O
a	O
number	O
of	O
polymers	O
,	O
are	O
available	O
from	O
the	O
Martini	B-Algorithm
website	O
.	O
</s>
