<s>
In	O
the	O
mathematical	O
subfield	O
of	O
numerical	B-General_Concept
analysis	I-General_Concept
,	O
an	O
M-spline	B-Algorithm
is	O
a	O
non-negative	O
spline	B-Algorithm
function	I-Algorithm
.	O
</s>
<s>
M-splines	B-Algorithm
can	O
be	O
efficiently	O
and	O
stably	O
computed	O
using	O
the	O
following	O
recursions	O
:	O
</s>
<s>
M-splines	B-Algorithm
can	O
be	O
integrated	O
to	O
produce	O
a	O
family	O
of	O
monotone	B-Algorithm
splines	I-Algorithm
called	O
I-splines	B-Algorithm
.	O
</s>
<s>
M-splines	B-Algorithm
can	O
also	O
be	O
used	O
directly	O
as	O
basis	O
splines	B-Algorithm
for	O
regression	O
analysis	O
involving	O
positive	O
response	O
data	O
(	O
constraining	O
the	O
regression	O
coefficients	O
to	O
be	O
non-negative	O
)	O
.	O
</s>
