<s>
Lipiodol	B-Library
,	O
also	O
known	O
as	O
ethiodized	B-Library
oil	I-Library
,	O
is	O
a	O
poppyseed	O
oil	O
used	O
by	O
injection	O
as	O
a	O
radio-opaque	O
contrast	B-Algorithm
agent	I-Algorithm
that	O
is	O
used	O
to	O
outline	O
structures	O
in	O
radiological	O
investigations	O
.	O
</s>
<s>
It	O
is	O
used	O
in	O
chemoembolization	O
applications	O
as	O
a	O
contrast	B-Algorithm
agent	I-Algorithm
in	O
follow-up	O
imaging	O
.	O
</s>
<s>
Lipiodol	B-Library
is	O
also	O
used	O
in	O
lymphangiography	O
,	O
the	O
imaging	O
of	O
the	O
lymphatic	O
system	O
.	O
</s>
<s>
Recently	O
,	O
there	O
has	O
been	O
an	O
increasing	O
interest	O
in	O
the	O
use	O
of	O
Lipiodol	B-Library
as	O
a	O
therapeutic	O
agent	O
in	O
the	O
management	O
of	O
unexplained	O
infertility	O
,	O
using	O
a	O
procedure	O
called	O
Lipiodol	B-Library
flushing	O
.	O
</s>
<s>
A	O
systematic	O
review	O
has	O
suggested	O
a	O
significant	O
increase	O
in	O
fertility	O
,	O
especially	O
in	O
those	O
women	O
who	O
have	O
endometriosis	O
when	O
using	O
Lipiodol	B-Library
flushing	O
.	O
</s>
<s>
Historically	O
Lipiodol	B-Library
was	O
often	O
used	O
as	O
a	O
contrast	B-Algorithm
medium	I-Algorithm
at	O
hysterosalpingography	O
(	O
HSG	O
:	O
a	O
procedure	O
to	O
determine	O
tubal	O
patency	O
,	O
used	O
in	O
the	O
investigation	O
of	O
subfertility	O
)	O
.	O
</s>
<s>
There	O
is	O
also	O
an	O
important	O
safety	O
issue	O
with	O
Lipiodol	B-Library
in	O
that	O
intravasation	O
(	O
leakage	O
)	O
of	O
the	O
fluid	O
into	O
the	O
venous	O
system	O
has	O
caused	O
complications	O
in	O
the	O
past	O
.	O
</s>
<s>
Ethiodized	B-Library
oil	I-Library
is	O
composed	O
of	O
iodine	O
combined	O
with	O
ethyl	O
esters	O
of	O
fatty	O
acids	O
of	O
poppyseed	O
oil	O
,	O
primarily	O
as	O
ethyl	O
monoiodostearate	O
and	O
ethyl	O
diiodostearate	O
.	O
</s>
<s>
Lipiodol	B-Library
was	O
first	O
synthesized	O
by	O
Marcel	O
Guerbet	O
in	O
the	O
Paris	O
School	O
of	O
Pharmacy	O
in	O
1901	O
.	O
</s>
<s>
Historically	O
,	O
Lipiodol	B-Library
was	O
the	O
first	O
iodinated	B-Algorithm
contrast	I-Algorithm
agent	I-Algorithm
(	O
used	O
for	O
myelography	O
by	O
two	O
French	O
physicians	O
,	O
Jacques	O
Forestier	O
and	O
Jean	O
Sicard	O
in	O
1921	O
)	O
.	O
</s>
<s>
Lipiodol	B-Library
or	O
ethiodized	B-Library
oil	I-Library
for	O
interventional	O
procedure	O
,	O
was	O
solely	O
produced	O
and	O
marketed	O
by	O
Guerbet	O
until	O
Vivere	O
Imaging	O
launched	O
its	O
ethiodized	B-Library
oil	I-Library
in	O
the	O
brand	O
name	O
Vividol	O
in	O
2022	O
.	O
</s>
