<s>
LiSiCA	B-Application
(	O
Ligand	O
Similarity	O
using	O
Clique	O
Algorithm	O
)	O
is	O
a	O
ligand-based	O
virtual	O
screening	O
software	O
that	O
searches	O
for	O
2D	O
and	O
3D	O
similarities	O
between	O
a	O
reference	O
compound	O
and	O
a	O
database	O
of	O
target	O
compounds	O
which	O
should	O
be	O
represented	O
in	O
a	O
Mol2	O
format	O
.	O
</s>
<s>
LiSiCA	B-Application
is	O
also	O
available	O
as	O
LiSiCA	B-Application
PyMOL	B-Application
plugin	B-Application
both	O
on	O
Linux	O
and	O
Windows	O
operating	O
systems	O
.	O
</s>
<s>
As	O
an	O
input	O
LiSiCA	B-Application
requires	O
at	O
least	O
one	O
reference	O
compound	O
and	O
database	O
of	O
target	O
compounds	O
.	O
</s>
<s>
A	O
product	O
graph	O
generated	O
from	O
molecular	O
graphs	O
is	O
then	O
searched	O
using	O
fast	O
maximum	B-Algorithm
clique	I-Algorithm
algorithm	I-Algorithm
to	O
find	O
the	O
largest	O
substructure	O
common	O
to	O
both	O
compounds	O
.	O
</s>
<s>
LiSiCA	B-Application
can	O
search	O
2D	O
and	O
3D	O
similarities	O
between	O
a	O
reference	O
compound	O
and	O
a	O
database	O
of	O
target	O
compounds	O
.	O
</s>
<s>
Other	O
optional	O
parameters	O
LiSiCA	B-Application
uses	O
are	O
:	O
</s>
<s>
In	O
addition	O
LiSiCA	B-Application
PyMOL	B-Application
plugin	B-Application
also	O
offers	O
to	O
load	O
saved	O
results	O
.	O
</s>
<s>
The	O
Slovene	O
word	O
lisica	B-Application
means	O
'	O
fox	O
 '	O
,	O
which	O
is	O
why	O
the	O
logo	O
of	O
LiSiCA	B-Application
software	O
is	O
a	O
fox	O
holding	O
two	O
molecules	O
.	O
</s>
