<s>
Intravascular	B-Algorithm
fluorescence	I-Algorithm
is	O
a	O
catheter-based	O
molecular	B-Algorithm
imaging	I-Algorithm
technique	O
that	O
uses	O
near-infrared	O
fluorescence	O
to	O
detect	O
artery	O
wall	O
autofluorescence	O
(	O
NIRAF	O
)	O
or	O
fluorescence	O
generated	O
by	O
molecular	O
agents	O
injected	O
intravenously	O
(	O
NIRF	O
)	O
.	O
</s>
<s>
No	O
commercial	O
systems	O
based	O
on	O
intravascular	B-Algorithm
fluorescence	I-Algorithm
are	O
currently	O
on	O
the	O
market	O
,	O
however	O
,	O
significant	O
steps	O
forwards	O
in	O
intravascular	B-Algorithm
fluorescence	I-Algorithm
imaging	O
technology	O
have	O
been	O
made	O
between	O
2010-2016	O
.	O
</s>
<s>
It	O
is	O
usually	O
combined	O
with	O
structural	O
imaging	O
modalities	O
such	O
as	O
Intravascular	O
ultrasound	O
and/or	O
Intracoronary	B-Algorithm
optical	I-Algorithm
coherence	I-Algorithm
tomography	I-Algorithm
,	O
to	O
provide	O
functional	O
information	O
in	O
a	O
morphological	O
context	O
.	O
</s>
<s>
Intravascular	B-Algorithm
fluorescence	I-Algorithm
typically	O
used	O
laser-induced	O
fluorescence	O
to	O
stimulate	O
fluorescence	O
emission	O
of	O
particular	O
vessel	O
wall	O
and	O
plaque	O
components	O
or	O
previously	O
injected	O
molecular	O
agents	O
(	O
i.e.	O
,	O
molecular	B-Algorithm
imaging	I-Algorithm
)	O
.	O
</s>
<s>
Imaging	O
catheters	O
contain	O
an	O
optical	B-Architecture
fiber	I-Architecture
to	O
deliver	O
and	O
collect	O
light	O
to	O
and	O
from	O
inner	O
lumen	O
of	O
human	O
body	O
through	O
semi-invasive	O
interventions	O
(	O
e.g.	O
,	O
percutaneous	O
coronary	O
intervention	O
in	O
case	O
of	O
coronary	O
arteries	O
)	O
.	O
</s>
<s>
Several	O
research	O
studies	O
demonstrated	O
the	O
role	O
of	O
intravascular	B-Algorithm
fluorescence	I-Algorithm
for	O
the	O
diagnosis	O
of	O
vascular	O
diseases	O
.	O
</s>
<s>
Plaque	O
autofluorescence	O
has	O
been	O
used	O
in	O
a	O
first-in-man	O
study	O
in	O
coronary	O
arteries	O
in	O
combination	O
with	O
Intracoronary	B-Algorithm
optical	I-Algorithm
coherence	I-Algorithm
tomography	I-Algorithm
(	O
OCT	O
)	O
.	O
</s>
