<s>
Internal	B-Application
Coordinate	I-Application
Mechanics	I-Application
(	O
ICM	O
)	O
is	O
a	O
software	O
program	O
and	O
algorithm	O
to	O
predict	O
low-energy	O
conformations	O
of	O
molecules	O
by	O
sampling	O
the	O
space	O
of	O
internal	O
coordinates	O
(	O
bond	O
lengths	O
,	O
bond	O
angles	O
and	O
dihedral	O
angles	O
)	O
defining	O
molecular	O
geometry	O
.	O
</s>
<s>
In	O
ICM	O
each	O
molecule	O
is	O
constructed	O
as	O
a	O
tree	O
from	O
an	O
entry	O
atom	B-Language
where	O
each	O
next	O
atom	B-Language
is	O
built	O
iteratively	O
from	O
the	O
preceding	O
three	O
atoms	O
via	O
three	O
internal	O
variables	O
.	O
</s>
