<s>
IntFOLD	B-Application
(	O
Integrated	O
Fold	O
Recognition	O
)	O
is	O
fully	O
automated	O
,	O
integrated	O
pipeline	O
for	O
prediction	O
of	O
3D	O
structure	O
and	O
function	O
from	O
amino	O
acid	O
sequences	O
.	O
</s>
<s>
The	O
pipeline	O
is	O
wrapped	O
up	O
and	O
deployed	O
as	O
a	O
Web	B-Application
Server	I-Application
.	O
</s>
<s>
IntFOLD	B-Application
server	O
provides	O
the	O
tertiary	O
structure	O
prediction	O
at	O
a	O
competitive	O
accuracy	O
and	O
combines	O
the	O
cutting	O
edge	O
methods	O
including	O
IntFOLD-TS	O
for	O
generation	O
of	O
3D	O
models	O
,	O
ModFOLD	O
for	O
3D	O
model	O
quality	O
estimation	O
,	O
ReFOLD	O
for	O
refinement	O
of	O
3D	O
models	O
,	O
DisoCLUST	O
for	O
disorder	O
prediction	O
,	O
DomFOLD	O
for	O
structural	O
domain	O
prediction	O
,	O
and	O
FunFOLD	O
for	O
protein	O
ligand	O
binding	O
site	O
prediction	O
.	O
</s>
<s>
IntFOLD	B-Application
Web	B-Application
Server	I-Application
has	O
completed	O
over	O
∼200	O
000	O
structure	O
predictions	O
since	O
January	O
2010	O
.	O
</s>
<s>
The	O
IntFOLD	B-Application
output	O
is	O
presented	O
via	O
a	O
user-friendly	O
interface	O
for	O
the	O
use	O
of	O
life	O
scientists	O
.	O
</s>
<s>
The	O
IntFOLD	B-Application
method	O
was	O
firstly	O
benchmarked	O
in	O
Critical	O
Assessment	O
of	O
Techniques	O
for	O
Protein	O
Structure	O
Prediction	O
9	O
(	O
CASP9	O
)	O
and	O
ranked	O
among	O
the	O
top	O
5	O
.	O
</s>
<s>
Some	O
of	O
the	O
several	O
domains	O
in	O
which	O
IntFOLD	B-Application
has	O
been	O
applied	O
so	O
far	O
are	O
listed	O
below	O
.	O
</s>
<s>
IntFOLD	B-Application
was	O
used	O
to	O
generate	O
3D	O
models	O
of	O
the	O
SARS-CoV-2	O
targets	O
for	O
the	O
CASP	O
Commons	O
COVID-19	O
initiative	O
and	O
elsewhere	O
accelerating	O
the	O
race	O
of	O
vaccines	O
and	O
other	O
therapeutics	O
development	O
with	O
regard	O
to	O
COVID-19	O
pandemic	O
.	O
</s>
<s>
In	O
other	O
aspect	O
of	O
chronic	O
diseases	O
,	O
IntFOLD	B-Application
was	O
used	O
to	O
model	O
HEV	O
PCP	O
,	O
an	O
essential	O
protein	O
of	O
Hepatitis	O
E	O
virus	O
causing	O
Hepatitis	O
E	O
disease	O
.	O
</s>
<s>
IntFOLD	B-Application
has	O
been	O
used	O
in	O
different	O
aspects	O
of	O
food	O
security	O
.	O
</s>
<s>
IntFOLD	B-Application
was	O
used	O
to	O
model	O
Chitin	O
proteins	O
in	O
Podosphaera	O
xanthii	O
,	O
a	O
causal	O
agent	O
of	O
fungal	O
disease	O
called	O
cucurbit	O
powdery	O
mildew	O
,	O
which	O
hamper	O
crop	O
productivity	O
.	O
</s>
<s>
IntFOLD	B-Application
has	O
been	O
used	O
as	O
one	O
of	O
the	O
standard	O
server-based	O
methods	O
in	O
validating	O
the	O
performance	O
of	O
some	O
of	O
the	O
newer	O
methods	O
used	O
in	O
prediction	O
of	O
the	O
3D-protein	O
models	O
.	O
</s>
