<s>
ITK	B-Language
is	O
a	O
cross-platform	B-Operating_System
,	O
open-source	O
application	O
development	O
framework	O
widely	O
used	O
for	O
the	O
development	O
of	O
image	B-Algorithm
segmentation	I-Algorithm
and	O
image	B-Algorithm
registration	I-Algorithm
programs	O
.	O
</s>
<s>
Segmentation	B-Algorithm
is	O
the	O
process	O
of	O
identifying	O
and	O
classifying	O
data	O
found	O
in	O
a	O
digitally	O
sampled	O
representation	O
.	O
</s>
<s>
Typically	O
the	O
sampled	O
representation	O
is	O
an	O
image	O
acquired	O
from	O
such	O
medical	O
instrumentation	O
as	O
CT	O
or	O
MRI	B-Algorithm
scanners	O
.	O
</s>
<s>
For	O
example	O
,	O
in	O
the	O
medical	O
environment	O
,	O
a	O
CT	O
scan	O
may	O
be	O
aligned	O
with	O
an	O
MRI	B-Algorithm
scan	O
in	O
order	O
to	O
combine	O
the	O
information	O
contained	O
in	O
both	O
.	O
</s>
<s>
ITK	B-Language
was	O
developed	O
with	O
funding	O
from	O
the	O
National	O
Library	O
of	O
Medicine	O
(	O
U.S.	O
)	O
as	O
an	O
open	O
resource	O
of	O
algorithms	O
for	O
analyzing	O
the	O
images	O
of	O
the	O
Visible	O
Human	O
Project	O
.	O
</s>
<s>
ITK	B-Language
stands	O
for	O
The	O
Insight	B-Language
Segmentation	I-Language
and	I-Language
Registration	I-Language
Toolkit	I-Language
.	O
</s>
<s>
The	O
toolkit	O
provides	O
leading-edge	O
segmentation	B-Algorithm
and	O
registration	O
algorithms	O
in	O
two	O
,	O
three	O
,	O
and	O
more	O
dimensions	O
.	O
</s>
<s>
ITK	B-Language
uses	O
the	O
CMake	B-Language
build	O
environment	O
to	O
manage	O
the	O
configuration	O
process	O
.	O
</s>
<s>
The	O
software	O
is	O
implemented	O
in	O
C++	B-Language
and	O
it	O
is	O
wrapped	O
for	O
Python	B-Language
.	O
</s>
<s>
An	O
offshoot	O
of	O
the	O
ITK	B-Language
project	O
providing	O
a	O
simplified	O
interface	O
to	O
ITK	B-Language
in	O
eight	O
programming	O
languages	O
,	O
SimpleITK	B-Language
,	O
is	O
also	O
under	O
active	O
development	O
.	O
</s>
<s>
In	O
1999	O
the	O
US	O
National	O
Library	O
of	O
Medicine	O
of	O
the	O
National	O
Institutes	O
of	O
Health	O
awarded	O
a	O
three-year	O
contract	O
to	O
develop	O
an	O
open-source	O
registration	O
and	O
segmentation	B-Algorithm
toolkit	O
,	O
which	O
eventually	O
came	O
to	O
be	O
known	O
as	O
the	O
Insight	O
Toolkit	O
(	O
ITK	B-Language
)	O
.	O
</s>
<s>
ITK	B-Language
's	O
NLM	O
Project	O
Manager	O
was	O
Dr.	O
Terry	O
Yoo	O
,	O
who	O
coordinated	O
the	O
six	O
prime	O
contractors	O
who	O
made	O
up	O
the	O
Insight	O
Software	O
Consortium	O
.	O
</s>
<s>
ITK	B-Language
is	O
an	O
open-source	O
software	O
toolkit	O
for	O
performing	O
registration	O
and	O
segmentation	B-Algorithm
.	O
</s>
<s>
Segmentation	B-Algorithm
is	O
the	O
process	O
of	O
identifying	O
and	O
classifying	O
data	O
found	O
in	O
a	O
digitally	O
sampled	O
representation	O
.	O
</s>
<s>
Typically	O
the	O
sampled	O
representation	O
is	O
an	O
image	O
acquired	O
from	O
such	O
medical	O
instrumentation	O
as	O
CT	O
or	O
MRI	B-Algorithm
scanners	O
.	O
</s>
<s>
For	O
example	O
,	O
in	O
the	O
medical	O
environment	O
,	O
a	O
CT	O
scan	O
may	O
be	O
aligned	O
with	O
an	O
MRI	B-Algorithm
scan	O
in	O
order	O
to	O
combine	O
the	O
information	O
contained	O
in	O
both	O
.	O
</s>
<s>
ITK	B-Language
is	O
implemented	O
in	O
C++	B-Language
.	O
</s>
<s>
ITK	B-Language
is	O
cross-platform	B-Operating_System
,	O
using	O
the	O
CMake	B-Language
build	O
environment	O
to	O
manage	O
the	O
compilation	O
process	O
.	O
</s>
<s>
In	O
addition	O
,	O
an	O
automated	O
wrapping	O
process	O
generates	O
interfaces	O
between	O
C++	B-Language
and	O
other	O
programming	O
languages	O
such	O
as	O
Java	O
and	O
Python	B-Language
.	O
</s>
<s>
ITK	B-Language
's	O
implementation	O
employs	O
the	O
technique	O
of	O
generic	B-Language
programming	I-Language
through	O
the	O
use	O
of	O
C++	B-Language
templates	O
.	O
</s>
<s>
Because	O
ITK	B-Language
is	O
an	O
open-source	O
project	O
,	O
developers	O
from	O
around	O
the	O
world	O
can	O
use	O
,	O
debug	O
,	O
maintain	O
,	O
and	O
extend	O
the	O
software	O
.	O
</s>
<s>
ITK	B-Language
uses	O
a	O
model	O
of	O
software	O
development	O
referred	O
to	O
as	O
extreme	O
programming	O
.	O
</s>
<s>
Communication	O
among	O
the	O
members	O
of	O
the	O
ITK	B-Language
community	O
is	O
what	O
helps	O
manage	O
the	O
rapid	O
evolution	O
of	O
the	O
software	O
.	O
</s>
<s>
In	O
ITK	B-Language
,	O
an	O
extensive	O
testing	O
process	O
(	O
using	O
)	O
is	O
in	O
place	O
that	O
measures	O
the	O
quality	O
on	O
a	O
daily	O
basis	O
.	O
</s>
<s>
Because	O
ITK	B-Language
is	O
an	O
open-source	O
system	O
,	O
anybody	O
can	O
make	O
contributions	O
to	O
the	O
project	O
.	O
</s>
<s>
ITK	B-Language
is	O
copyrighted	O
by	O
the	O
Insight	O
Software	O
Consortium	O
,	O
a	O
non-profit	O
alliance	O
of	O
organizations	O
and	O
individuals	O
interested	O
in	O
supporting	O
ITK	B-Language
.	O
</s>
<s>
Starting	O
with	O
ITK	B-Language
version	O
3.6	O
,	O
the	O
software	O
is	O
distributed	O
under	O
a	O
BSD	O
open-source	O
license	O
.	O
</s>
<s>
Version	O
4.0	O
uses	O
Apache	B-Application
2.0	I-Application
License	I-Application
.	O
</s>
<s>
The	O
licensed	O
was	O
changed	O
to	O
Apache	B-Application
2.0	I-Application
with	O
version	O
4.0	O
to	O
adopt	O
a	O
modern	O
license	O
with	O
patent	O
protection	O
provisions	O
.	O
</s>
<s>
Versions	O
of	O
ITK	B-Language
previous	O
to	O
ITK	B-Language
3.6	O
were	O
distributed	O
under	O
a	O
modified	O
BSD	O
License	O
.	O
</s>
<s>
The	O
main	O
motivation	O
for	O
adopting	O
a	O
BSD	O
license	O
starting	O
with	O
ITK	B-Language
3.6	O
,	O
was	O
to	O
have	O
an	O
OSI-approved	O
license	O
.	O
</s>
<s>
The	O
following	O
sections	O
summarize	O
the	O
technical	O
features	O
of	O
the	O
NLM	O
's	O
Insight	O
ITK	B-Language
toolkit	O
.	O
</s>
<s>
The	O
toolkit	O
provides	O
data	O
representation	O
and	O
algorithms	O
for	O
performing	O
segmentation	B-Algorithm
and	O
registration	O
.	O
</s>
<s>
These	O
are	O
left	O
to	O
other	O
toolkits	O
(	O
such	O
as	O
VTK	B-Language
,	O
VISPACK	O
,	O
3DViewnix	O
,	O
MetaImage	O
,	O
etc	O
.	O
)	O
</s>
<s>
In	O
Insight	O
,	O
testing	O
is	O
performed	O
continuously	O
as	O
files	O
are	O
checked	O
in	O
,	O
and	O
every	O
night	O
across	O
multiple	B-Operating_System
platforms	I-Operating_System
and	O
compilers	O
.	O
</s>
<s>
The	O
ITK	B-Language
testing	O
dashboard	O
,	O
where	O
testing	O
results	O
are	O
posted	O
,	O
is	O
central	O
to	O
this	O
process	O
.	O
</s>
<s>
The	O
toolkit	O
is	O
implemented	O
using	O
generic	B-Language
programming	I-Language
principles	O
.	O
</s>
<s>
Such	O
heavily	O
templated	O
C++	B-Language
code	I-Language
challenges	O
many	O
compilers	O
;	O
hence	O
development	O
was	O
carried	O
out	O
with	O
the	O
latest	O
versions	O
of	O
the	O
MSVC	O
,	O
Sun	O
,	O
gcc	O
,	O
Intel	O
,	O
and	O
SGI	O
compilers	O
.	O
</s>
<s>
The	O
toolkit	O
is	O
cross-platform	B-Operating_System
(	O
Unix	O
,	O
Windows	O
and	O
Mac	O
OS	O
X	O
)	O
.	O
</s>
<s>
The	O
toolkit	O
supports	O
multiple	O
language	O
bindings	O
,	O
including	O
such	O
languages	O
as	O
Tcl	O
,	O
Python	B-Language
,	O
and	O
Java	O
.	O
</s>
<s>
ITK	B-Language
uses	O
the	O
CMake	B-Language
(	O
cross-platform	B-Operating_System
make	O
)	O
build	O
environment	O
.	O
</s>
<s>
CMake	B-Language
is	O
an	O
operating	O
system	O
and	O
compiler	O
independent	O
build	O
process	O
that	O
produces	O
native	O
build	O
files	O
appropriate	O
to	O
the	O
OS	O
and	O
compiler	O
that	O
it	O
is	O
run	O
with	O
.	O
</s>
<s>
On	O
Unix	O
CMake	B-Language
produces	O
makefiles	O
and	O
on	O
Windows	O
CMake	B-Language
generates	O
projects	O
and	O
workspaces	O
.	O
</s>
<s>
ITK	B-Language
supports	O
an	O
extensive	O
testing	O
environment	O
.	O
</s>
<s>
The	O
code	O
is	O
tested	O
daily	O
(	O
and	O
even	O
continuously	O
)	O
on	O
many	O
hardware/operating	O
system/compiler	O
combinations	O
and	O
the	O
results	O
are	O
posted	O
daily	O
on	O
the	O
ITK	B-Language
testing	O
dashboard	O
.	O
</s>
<s>
ITK	B-Language
uses	O
many	O
advanced	O
design	O
patterns	O
and	O
generic	B-Language
programming	I-Language
.	O
</s>
<s>
A	O
number	O
of	O
resources	O
are	O
available	O
to	O
learn	O
more	O
about	O
ITK	B-Language
.	O
</s>
<s>
The	O
ITK	B-Language
web	O
pages	O
are	O
located	O
at	O
.	O
</s>
<s>
Developers	O
should	O
also	O
look	O
at	O
the	O
ITK	B-Language
style	O
guide	O
Insight/Documentation/Style.pdf	O
found	O
in	O
the	O
source	O
distribution	O
.	O
</s>
<s>
A	O
great	O
way	O
to	O
learn	O
about	O
ITK	B-Language
is	O
to	O
see	O
how	O
it	O
is	O
used	O
.	O
</s>
<s>
There	O
are	O
four	O
places	O
to	O
find	O
applications	O
of	O
ITK	B-Language
.	O
</s>
<s>
The	O
Insight/Examples/	O
source	O
code	O
examples	O
distributed	O
with	O
ITK	B-Language
.	O
</s>
<s>
In	O
addition	O
,	O
it	O
is	O
heavily	O
commented	O
and	O
works	O
in	O
combination	O
with	O
the	O
ITK	B-Language
Software	O
Guide	O
.	O
</s>
<s>
The	O
testing	O
directories	O
distributed	O
with	O
ITK	B-Language
are	O
simple	O
,	O
mainly	O
undocumented	O
examples	O
of	O
how	O
to	O
use	O
the	O
code	O
.	O
</s>
<s>
In	O
2004	O
ITK-SNAP	B-Application
(	O
)	O
was	O
developed	O
from	O
SNAP	O
and	O
became	O
a	O
popular	O
free	O
segmentation	B-Algorithm
software	O
using	O
ITK	B-Language
and	O
having	O
a	O
nice	O
and	O
simple	O
user	O
interface	O
.	O
</s>
