<s>
ISAS	B-Algorithm
(	O
Ictal-Interictal	B-Algorithm
SPECT	I-Algorithm
Analysis	I-Algorithm
by	I-Algorithm
SPM	I-Algorithm
)	O
is	O
an	O
objective	O
tool	O
for	O
analyzing	O
ictal	O
vs.	O
interictal	O
SPECT	O
scans	O
.	O
</s>
<s>
ISAS	B-Algorithm
was	O
introduced	O
and	O
validated	O
in	O
two	O
recent	O
studies	O
(	O
Chang	O
et	O
al.	O
,	O
2002	O
;	O
McNally	O
et	O
al.	O
,	O
2005	O
)	O
.	O
</s>
<s>
This	O
site	O
is	O
a	O
technical	O
supplement	O
to	O
(	O
McNally	O
et	O
al.	O
,	O
2005	O
)	O
,	O
which	O
should	O
enable	O
ISAS	B-Algorithm
to	O
be	O
implemented	O
at	O
any	O
center	O
for	O
further	O
study	O
and	O
analysis	O
.	O
</s>
<s>
The	O
basic	O
idea	O
of	O
ISAS	B-Algorithm
is	O
to	O
compute	O
the	O
difference	O
between	O
an	O
ictal	O
and	O
interictal	O
SPECT	O
scan	O
for	O
a	O
single	O
patient	O
.	O
</s>
<s>
Details	O
of	O
ISAS	B-Algorithm
interpretation	O
can	O
be	O
found	O
in	O
McNally	O
et	O
al.	O
,	O
2005	O
,	O
but	O
in	O
summary	O
:	O
</s>
<s>
The	O
requirements	O
for	O
implementing	O
ISAS	B-Algorithm
are	O
relatively	O
simple	O
.	O
</s>
<s>
All	O
that	O
is	O
needed	O
is	O
a	O
computer	O
running	O
MATLAB	B-Language
and	O
an	O
operator	O
with	O
sufficient	O
imaging	O
experience	O
to	O
download	O
and	O
implement	O
the	O
SPM	O
(	O
statistical	O
parametric	O
mapping	O
)	O
analysis	O
.	O
</s>
<s>
NOTE	O
:	O
ISAS	B-Algorithm
has	O
been	O
tested	O
and	O
confirmed	O
to	O
work	O
with	O
SPM2	O
and	O
the	O
following	O
MATLAB	B-Language
versions	O
-	O
6.1	O
,	O
6.5.1	O
,	O
and	O
7.0.4	O
.	O
</s>
<s>
In	O
order	O
to	O
ensure	O
correctness	O
,	O
both	O
Matlab	B-Language
and	O
SPM	O
should	O
be	O
kept	O
updated	O
with	O
the	O
latest	O
service	O
packs	O
and	O
patches	O
.	O
</s>
<s>
The	O
intent	O
of	O
ISAS	B-Algorithm
and	O
the	O
ISAS	B-Algorithm
website	O
is	O
to	O
begin	O
to	O
fill	O
the	O
need	O
for	O
epilepsy	O
SPECT	O
image	O
analysis	O
,	O
by	O
providing	O
a	O
freely	O
available	O
method	O
that	O
can	O
be	O
implemented	O
anywhere	O
.	O
</s>
<s>
This	O
study	O
,	O
together	O
with	O
the	O
ISAS	B-Algorithm
website	O
,	O
provides	O
a	O
complete	O
description	O
of	O
the	O
ISAS	B-Algorithm
method	O
,	O
and	O
validates	O
this	O
approach	O
with	O
a	O
group	O
of	O
mesial	O
temporal	O
and	O
neocortical	O
epilepsy	O
patients	O
.	O
</s>
<s>
ISAS	B-Algorithm
was	O
introduced	O
in	O
this	O
study	O
,	O
and	O
compared	O
to	O
conventional	O
SPECT	O
difference	O
imaging	O
.	O
</s>
