<s>
ITK-SNAP	B-Application
is	O
an	O
interactive	O
software	O
application	O
that	O
allows	O
users	O
to	O
navigate	O
three-dimensional	O
medical	O
images	O
,	O
manually	O
delineate	O
anatomical	O
regions	O
of	O
interest	O
,	O
and	O
perform	O
automatic	O
image	B-Algorithm
segmentation	I-Algorithm
.	O
</s>
<s>
ITK-SNAP	B-Application
is	O
most	O
frequently	O
used	O
to	O
work	O
with	O
magnetic	O
resonance	O
imaging	O
(	O
MRI	O
)	O
,	O
cone-beam	O
computed	O
tomography	O
(	O
CBCT	O
)	O
and	O
computed	O
tomography	O
(	O
CT	O
)	O
data	O
sets	O
.	O
</s>
<s>
The	O
linked	O
cursor	O
also	O
works	O
across	O
ITK-SNAP	B-Application
sessions	O
,	O
making	O
it	O
possible	O
to	O
navigate	O
multimodality	O
imaging	O
data	O
(	O
e.g.	O
,	O
two	O
MRI	O
scans	O
of	O
a	O
subject	O
from	O
a	O
single	O
session	O
)	O
.	O
</s>
<s>
Manual	O
segmentation	B-Algorithm
ITK-SNAP	B-Application
provides	O
tools	O
for	O
manual	O
delineation	O
of	O
anatomical	O
structures	O
in	O
images	O
.	O
</s>
<s>
This	O
makes	O
it	O
easier	O
to	O
ensure	O
that	O
the	O
segmentation	B-Algorithm
maintains	O
reasonable	O
shape	O
in	O
3D	O
.	O
</s>
<s>
Automatic	O
segmentation	B-Algorithm
ITK-SNAP	B-Application
provides	O
automatic	O
functionality	O
segmentation	B-Algorithm
using	O
the	O
level-set	B-Algorithm
method	I-Algorithm
.	O
</s>
<s>
ITK-SNAP	B-Application
is	O
open-source	B-Application
software	I-Application
distributed	O
under	O
the	O
GNU	B-License
General	I-License
Public	I-License
License	I-License
.	O
</s>
<s>
It	O
is	O
written	O
in	O
C++	B-Language
and	O
it	O
leverages	O
the	O
Insight	B-Language
Segmentation	I-Language
and	I-Language
Registration	I-Language
Toolkit	I-Language
(	O
ITK	B-Language
)	O
library	O
.	O
</s>
<s>
ITK-SNAP	B-Application
can	O
read	O
and	O
write	O
a	O
variety	O
of	O
medical	O
image	O
formats	O
,	O
including	O
DICOM	O
,	O
NIfTI	O
,	O
and	O
Mayo	O
Analyze	O
.	O
</s>
<s>
It	O
also	O
offers	O
limited	O
support	O
for	O
multi-component	O
(	O
e.g.	O
,	O
diffusion	B-Algorithm
tensor	I-Algorithm
imaging	I-Algorithm
)	O
and	O
multi-variate	O
imaging	O
data	O
.	O
</s>
