<s>
ISIS/Draw	B-Application
was	O
a	O
chemical	B-Application
structure	I-Application
drawing	I-Application
program	I-Application
developed	O
by	O
MDL	O
Information	O
Systems	O
.	O
</s>
<s>
MDL	O
offered	O
their	O
ISIS	O
(	O
Integrated	O
Scientific	O
Information	O
System	O
)	O
products	O
including	O
ISIS/Draw	B-Application
as	O
components	O
of	O
the	O
MACCS	O
system	O
,	O
specifically	O
to	O
allow	O
chemists	O
to	O
use	O
a	O
graphical	B-Application
interface	I-Application
to	O
register	O
new	O
compounds	O
into	O
corporate	O
databases	O
and	O
to	O
search	O
these	O
databases	O
by	O
structure	O
or	O
part-structure	O
.	O
</s>
<s>
ISIS/Draw	B-Application
structures	O
could	O
be	O
incorporated	O
into	O
other	O
documents	O
,	O
for	O
example	O
using	O
the	O
word	B-General_Concept
processor	I-General_Concept
software	O
which	O
was	O
becoming	O
available	O
in	O
the	O
1980s	O
,	O
hence	O
providing	O
full	O
electronic	O
publishing	O
for	O
chemists	O
.	O
</s>
<s>
MDL	O
released	O
many	O
versions	O
of	O
the	O
software	O
and	O
made	O
ISIS/Draw	B-Application
freely	O
available	O
for	O
non-commercial	O
use	O
:	O
version	O
2.5	O
was	O
available	O
to	O
run	O
on	O
Windows	B-Device
98	I-Device
.	O
</s>
<s>
By	O
2007	O
,	O
MDL	O
(	O
then	O
owned	O
by	O
Reed	B-Library
Elsevier	I-Library
)	O
merged	O
with	O
Symyx	O
Technologies	O
,	O
which	O
in	O
turn	O
was	O
acquired	O
by	O
Accelrys	O
in	O
2010	O
and	O
is	O
now	O
owned	O
by	O
Dassault	O
Systèmes	O
.	O
</s>
<s>
The	O
software	O
is	O
now	O
branded	O
as	O
BIOVIA	B-Application
Draw	I-Application
.	O
</s>
<s>
ISIS/Draw	B-Application
retained	O
its	O
own	O
proprietary	O
file	O
formats	O
with	O
the	O
extension	O
.skc	O
(	O
sketch	O
file	O
)	O
and	O
.rxn	O
(	O
for	O
reactions	O
)	O
and	O
because	O
of	O
its	O
role	O
in	O
preparing	O
database	O
queries	O
it	O
supported	O
a	O
variety	O
of	O
special	O
atom	O
and	O
bond	O
types	O
used	O
for	O
substructure	O
searching	O
,	O
such	O
as	O
wildcard	B-Algorithm
atoms	I-Algorithm
,	O
aromatic	O
bonds	O
,	O
ring	O
bonds	O
,	O
and	O
the	O
atom	O
mapping	O
required	O
for	O
reaction	O
searches	O
.	O
</s>
<s>
While	O
ISIS/Draw	B-Application
was	O
mainly	O
a	O
2D	O
drawing	O
program	O
,	O
it	O
had	O
some	O
3D	O
rotation	O
features	O
and	O
could	O
interface	O
with	O
Rasmol	B-Language
for	O
3D	O
visualization	O
and	O
rendering	O
.	O
</s>
<s>
ISIS/Draw	B-Application
also	O
included	O
structure	O
and	O
reaction	O
validation	O
features	O
and	O
could	O
calculate	O
elementary	O
properties	O
such	O
as	O
formula	O
and	O
molecular	O
weight	O
.	O
</s>
<s>
One	O
important	O
feature	O
of	O
the	O
MACCS	O
system	O
and	O
ISIS/Draw	B-Application
was	O
that	O
it	O
had	O
comprehensive	O
facilities	O
,	O
using	O
hatched	O
and	O
wedged	O
bonds	O
,	O
to	O
represent	O
relative	O
or	O
absolute	O
stereochemistry	O
and	O
chirality	O
and	O
to	O
recognise	O
cis	O
–	O
trans	O
isomerism	O
in	O
double	O
bonds	O
.	O
</s>
<s>
The	O
current	O
(	O
2020	O
)	O
implementation	O
of	O
the	O
software	O
is	O
called	O
BIOVIA	B-Application
Draw	I-Application
and	O
has	O
several	O
new	O
features	O
such	O
as	O
support	O
for	O
reading	O
and	O
writing	O
International	O
Chemical	O
Identifiers	O
(	O
InChi	O
)	O
and	O
converting	O
IUPAC	O
names	O
into	O
structure	O
drawings	O
.	O
</s>
