<s>
IMOD	B-Application
is	O
an	O
open-source	O
,	O
cross-platform	O
suite	O
of	O
modeling	O
,	O
display	O
and	O
image	B-Algorithm
processing	I-Algorithm
programs	O
used	O
for	O
3D	B-Algorithm
reconstruction	I-Algorithm
and	O
modeling	O
of	O
microscopy	O
images	O
with	O
a	O
special	O
emphasis	O
on	O
electron	O
microscopy	O
data	O
.	O
</s>
<s>
IMOD	B-Application
has	O
been	O
used	O
across	O
a	O
range	O
of	O
scales	O
from	O
macromolecule	O
structures	O
to	O
organelles	O
to	O
whole	O
cells	O
and	O
can	O
also	O
be	O
used	O
for	O
optical	O
sections	O
.	O
</s>
<s>
IMOD	B-Application
includes	O
tools	O
for	O
image	O
reconstruction	O
,	O
image	B-Algorithm
segmentation	I-Algorithm
,	O
3D	O
mesh	O
modeling	O
and	O
analysis	O
of	O
2D	O
and	O
3D	O
data	O
.	O
</s>
<s>
IMOD	B-Application
was	O
developed	O
at	O
the	O
.	O
</s>
<s>
IMOD	B-Application
was	O
first	O
released	O
in	O
1995	O
,	O
is	O
free	O
to	O
and	O
use	O
for	O
any	O
purpose	O
.	O
</s>
<s>
IMOD	B-Application
includes	O
over	O
180	O
command	O
line	O
programs	O
and	O
three	O
main	O
GUI	B-Application
programs	O
:	O
</s>
<s>
3dmod	O
-	O
IMOD	B-Application
's	O
main	O
GUI	B-Application
used	O
to	O
view	O
and	O
segment	O
images	O
and	O
3D	O
vector	O
models	O
.	O
</s>
<s>
eTomo	O
-	O
A	O
program	O
used	O
to	O
reconstruct	O
3D	O
volumes	O
by	O
joining	O
smaller	O
volumes	O
and/or	O
guiding	O
the	O
user	O
through	O
the	O
process	O
of	O
tomographic	B-Algorithm
reconstruction	I-Algorithm
of	O
single	O
and	O
dual	O
axis	O
tilt	O
series	O
.	O
</s>
<s>
Image	O
Format	O
:	O
The	O
main	O
image	O
format	O
supported	O
by	O
IMOD	B-Application
is	O
MRC	O
file	O
format	O
,	O
which	O
typically	O
have	O
a	O
"	O
.st	O
"	O
,	O
"	O
.mrc	O
"	O
or	O
"	O
.rec	O
"	O
extensions	O
and	O
represent	O
various	O
types	O
of	O
"	O
image	O
stacks	O
"	O
which	O
together	O
might	O
represent	O
a	O
tilt	O
series	O
or	O
3D	O
volume	O
.	O
</s>
<s>
IMOD	B-Application
will	O
also	O
open	O
TIF	O
files	O
and	O
includes	O
a	O
set	O
of	O
programs	O
to	O
convert	O
between	O
image	O
formats	O
including	O
common	O
microscopy	O
formats	O
like	O
"	O
.raw	O
"	O
and	O
"	O
.dm4	O
"	O
.	O
</s>
<s>
Vector	O
Format	O
:	O
IMOD	B-Application
saves	O
and	O
opens	O
vector	O
data	O
in	O
the	O
form	O
of	O
contour	O
(	O
polygons	O
)	O
and	O
meshes	O
in	O
an	O
,	O
typically	O
with	O
a	O
"	O
.mod	O
"	O
or	O
"	O
.fid	O
"	O
extension	O
.	O
</s>
<s>
These	O
IMOD	B-Application
model	O
files	O
are	O
typically	O
over-laid	O
over	O
the	O
top	O
of	O
an	O
image	O
file	O
and	O
can	O
be	O
used	O
to	O
annotate	O
and	O
segment	O
regions	O
of	O
interest	O
.	O
</s>
<s>
Reconstruction	O
of	O
single	O
and	O
combined	O
dual	O
axis	O
tilt-series	O
using	O
tomographic	B-Algorithm
reconstruction	I-Algorithm
techniques	O
.	O
</s>
<s>
Ability	O
to	O
align	O
and	O
then	O
warp	O
images	O
using	O
cross-correlation	O
and	O
the	O
Midas	O
GUI	B-Application
for	O
manual	O
alignment	O
.	O
</s>
<s>
Image	B-Algorithm
Processing	I-Algorithm
:	O
</s>
<s>
IMOD	B-Application
suite	O
includes	O
several	O
automatic	O
segmentation	B-Algorithm
programs	O
.	O
</s>
<s>
Segmentation	B-Algorithm
:	O
</s>
