<s>
IBIS	B-Application
(	O
server	O
)	O
(	O
Inferred	B-Application
Biomolecular	I-Application
Interaction	I-Application
Server	I-Application
)	O
is	O
a	O
server	O
developed	O
at	O
National	O
Institutes	O
of	O
Health	O
.	O
</s>
<s>
A	O
database	O
and	O
server	O
IBIS	B-Application
(	O
Inferred	B-Application
Biomolecular	I-Application
Interaction	I-Application
Server	I-Application
,	O
)	O
developed	O
at	O
,	O
reports	O
,	O
predicts	O
and	O
integrates	O
multiple	O
types	O
of	O
conserved	O
interactions	O
for	O
proteins	O
.	O
</s>
<s>
IBIS	B-Application
identifies	O
and	O
predicts	O
proteins	O
 '	O
interaction	O
partners	O
together	O
with	O
the	O
locations	O
of	O
the	O
corresponding	O
binding	O
sites	O
on	O
the	O
protein	O
query	O
.	O
</s>
<s>
IBIS	B-Application
also	O
allows	O
the	O
mapping	O
of	O
a	O
biomolecular	O
interaction	O
network	O
for	O
any	O
given	O
organism	O
,	O
human	O
interactome	O
derived	O
from	O
structural	O
complexes	O
is	O
available	O
at	O
.	O
</s>
<s>
To	O
focus	O
on	O
biologically	O
relevant	O
binding	O
sites	O
,	O
IBIS	B-Application
clusters	O
similar	O
binding	O
sites	O
found	O
in	O
homologous	O
proteins	O
based	O
on	O
the	O
sites’	O
conservation	O
of	O
sequence	O
and	O
structure	O
.	O
</s>
