<s>
In	O
the	O
mathematical	O
subfield	O
of	O
numerical	B-General_Concept
analysis	I-General_Concept
,	O
an	O
I-spline	B-Algorithm
is	O
a	O
monotone	B-Algorithm
spline	I-Algorithm
function	O
.	O
</s>
<s>
where	O
L	O
is	O
the	O
lower	O
limit	O
of	O
the	O
domain	O
of	O
the	O
splines	B-Algorithm
.	O
</s>
<s>
Since	O
M-splines	B-Algorithm
are	O
non-negative	O
,	O
I-splines	B-Algorithm
are	O
monotonically	O
non-decreasing	O
.	O
</s>
<s>
I-splines	B-Algorithm
can	O
be	O
used	O
as	O
basis	O
splines	B-Algorithm
for	O
regression	O
analysis	O
and	O
data	B-General_Concept
transformation	I-General_Concept
when	O
monotonicity	O
is	O
desired	O
(	O
constraining	O
the	O
regression	O
coefficients	O
to	O
be	O
non-negative	O
for	O
a	O
non-decreasing	O
fit	O
,	O
and	O
non-positive	O
for	O
a	O
non-increasing	O
fit	O
)	O
.	O
</s>
